ADAMTS12 - ADAM metallopeptidase with thrombospondin type 1 motif 12 Gene

中文名称：具有 1 型血小板反应蛋白基序 12 的 ADAM 金属肽酶

种属: Homo sapiens

同用名: PRO4389

关于 ADAMTS12

功能概要

该基因编码 ADAMTS (一种具有血小板反应蛋白基序的去整合素和金属蛋白酶) 蛋白家族的成员。该家族的成员共享几个不同的蛋白质模块，包括前肽区域、金属蛋白酶结构域、解整合素样结构域和 1 型血小板反应蛋白 (TS-1) 基序。该家族的个别成员在 C 端 TS-1 基序的数量上有所不同，有些成员具有独特的 C 端结构域。该基因编码的酶包含八个 TS-1 基序。它可能通过其蛋白水解活性或作为潜在参与细胞粘附调节的分子在胎儿发育过程中或肿瘤过程中在肺细胞中发挥作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The Enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]