MYL6 - myosin light chain 6 Gene

中文名称：肌球蛋白轻链 6

种属: Homo sapiens

同用名: LC17; ESMLC; LC17A; LC17B; MLC-3; MLC1SM; MLC3NM; MLC3SM; LC17-GI; LC17-NM

基因 ID: 4637 | 基因类型: protein coding

关于 MYL6

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:56,158,359-56,161,579 (from NCBI)

This gene has 21 transcripts (splice variants), 295 orthologues and 4 paralogues. Ubiquitous expression in fat (RPKM 771.0), endometrium (RPKM 608.0) and 25 other tissues.

功能概要

肌球蛋白是一种六聚体 ATP 酶细胞运动蛋白。它由两条重链、两条不可磷酸化的碱金属轻链和两条可磷酸化的调节轻链组成。该基因编码在平滑肌和非肌肉组织中表达的肌球蛋白碱性轻链。已经描述了代表几个假基因的基因组序列，并且已经为该基因鉴定了编码不同同种型的两个转录物变体。[RefSeq 提供，2008 年 7 月]

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a Myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

MYL6 基因产物(2)

mRNA	Protein	Name
NM_021019.5	NP_066299.2	myosin light polypeptide 6 isoform 1
NM_079423.4	NP_524147.2	myosin light polypeptide 6 isoform 2

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables structural constituent of muscle	IDA IDA: 通过直接分析推断	16953301	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in brush border	IDA IDA: 通过直接分析推断	22114352	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MYL6 蛋白结构

EF-hand_6

0
100
151 a.a.

蛋白主名

其他名称

myosin light polypeptide 6

17 kDa myosin light chain

MYL6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MYL6	P60660	NUDT21	Homo sapiens	O43809	Y2H Pooling	16189514
种属内	MYL6	P60660	NUDT21	Homo sapiens	O43809	Y2H Array	32296183
种属内	MYL6	P60660	NUDT21	Homo sapiens	O43809	Y2H Prey Pooling	32296183
种属内	MYL6	P60660	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
种属内	MYL6	P60660	AGR2	Homo sapiens	O95994	Y2H Array	32296183
种属内	MYL6	P60660	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
种属内	MYL6	P60660	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
种属内	MYL6	P60660	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
种属内	MYL6	P60660	ADAMTS12	Homo sapiens	P58397	Y2H Array	25416956
种属内	MYL6	P60660	ADAMTS12	Homo sapiens	P58397	Y2H Prey Pooling	25416956
种属内	MYL6	P60660	GAS2L3	Homo sapiens	Q86XJ1	Y2H Prey Pooling	32296183
种属内	MYL6	P60660	GAS2L3	Homo sapiens	Q86XJ1	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Noonan Syndrome 2

NS2	Noonan Syndrome, Autosomal Recessive
Noonan Syndrome 2, Autosomal Recessive	Noonan Syndrome, Type 2

Adrenal Gland Pheochromocytoma

Pheochromocytoma

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy	Familial Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 1	CMH1
Hypertrophic Cardiomyopathy 19	CMH
Ventricular Hypertrophy, Hereditary	Ash
Hypertrophic Subaortic Stenosis, Idiopathic	Cardiomyopathy, Familial Hypertrophic
Cardiomyopathy, Hypertrophic, 1, Digenic	Cardiomyopathy, Familial Hypertrophic 1
Hcm	Hereditary Ventricular Hypertrophy
Idiopathic Hypertrophic Subaortic Stenosis	Hypertrophic Cardiomyopathy
Cardiomyopathy, Hypertrophic, Familial	Cardiomyopathy, Hypertrophic, 1
Familial Asymmetric Septal Hypertrophy	Heritable Hypertrophic Cardiomyopathy
Fhc	Cardiomyopathy, Hypertrophic, Familial, Type 1

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08918	MYL6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS08919	MYL6B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	MYL6	VGNC	VGNC:68386
Rattus norvegicus	MYL6	RGD	RGD:1589019
Mus musculus	MYL6	MGD	MGI:109318
Bos taurus	MYL6	VGNC	VGNC:50223

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MYL6 - myosin light chain 6 Gene

关于 MYL6

功能概要

MYL6 基因产物(2)

MYL6 蛋白结构

MYL6 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

MYL6 - myosin light chain 6 Gene

关于 MYL6

功能概要

MYL6 基因产物(2)

MYL6 蛋白结构

MYL6 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z