Comp - cartilage oligomeric matrix protein Gene

种属: Mus musculus

同用名: TSP5

基因 ID: 12845 | 基因类型: protein coding

关于 Comp

功能概要

Enables BMP binding activity; Integrin binding activity; and protease binding activity. Acts upstream of or within several processes, including animal organ development; chondrocyte proliferation; and vasculature development. Located in extracellular space. Part of protein-containing complex. Is expressed in several structures, including connective tissue; embryo mesenchyme; notochord; placenta; and skeletal system. Used to study multiple epiphyseal dysplasia and pseudoachondroplasia. Human ortholog(s) of this gene implicated in carpal tunnel syndrome; multiple epiphyseal dysplasia 1; osteochondrodysplasia; and pseudoachondroplasia. Orthologous to human COMP (cartilage oligomeric matrix protein). [provided by Alliance of Genome Resources, Apr 2022]

Comp 基因产物(1)

mRNA	Protein	Name
NM_016685.2	NP_057894.2	cartilage oligomeric matrix protein precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables BMP binding	IPI IPI: 通过物理相互作用推断	21350216	MGI
enables integrin binding	IPI IPI: 通过物理相互作用推断	27151399	MGI
enables protease binding	IPI IPI: 通过物理相互作用推断	16611630	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	16611630	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within BMP signaling pathway	IMP IMP: 通过突变表型推断	21350216	MGI
acts upstream of or within apoptotic process	IMP IMP: 通过突变表型推断	17588960	MGI
acts upstream of or within artery morphogenesis	IMP IMP: 通过突变表型推断	27151399	MGI
acts upstream of or within blood coagulation	IMP IMP: 通过突变表型推断	26045608	MGI
acts upstream of or within bone growth	IMP IMP: 通过突变表型推断	17588960	MGI
acts upstream of or within bone mineralization	IMP IMP: 通过突变表型推断	27151399	MGI
acts upstream of or within bone morphogenesis	IGI IGI: 通过遗传相互作用推断	18191556	MGI
acts upstream of or within cartilage development	IGI IGI: 通过遗传相互作用推断	18191556	MGI
acts upstream of or within cartilage development	IMP IMP: 通过突变表型推断	17588960	MGI
involved in cartilage homeostasis	IDA IDA: 通过直接分析推断	32747625	MGI
acts upstream of or within cellular senescence	IMP IMP: 通过突变表型推断	27498005	MGI
acts upstream of or within chondrocyte development	IMP IMP: 通过突变表型推断	17588960	MGI
acts upstream of or within chondrocyte proliferation	IGI IGI: 通过遗传相互作用推断	18191556	MGI
acts upstream of or within chondrocyte proliferation	IMP IMP: 通过突变表型推断	17588960	MGI
acts upstream of or within collagen fibril organization	IMP IMP: 通过突变表型推断	19808781	MGI
acts upstream of or within endochondral bone growth	IMP IMP: 通过突变表型推断	20138147	MGI
acts upstream of or within growth plate cartilage development	IGI IGI: 通过遗传相互作用推断	18191556	MGI
acts upstream of or within growth plate cartilage development	IMP IMP: 通过突变表型推断	17588960	MGI
acts upstream of or within limb development	IMP IMP: 通过突变表型推断	17588960	MGI
acts upstream of or within multicellular organism growth	IMP IMP: 通过突变表型推断	17588960	MGI
acts upstream of or within muscle cell development	IMP IMP: 通过突变表型推断	19808781	MGI
acts upstream of or within musculoskeletal movement	IMP IMP: 通过突变表型推断	19808781	MGI
acts upstream of or within negative regulation of hemostasis	IMP IMP: 通过突变表型推断	26045608	MGI
acts upstream of or within neuromuscular process	IMP IMP: 通过突变表型推断	24312420	MGI
acts upstream of or within ossification	IMP IMP: 通过突变表型推断	21350216	MGI
acts upstream of or within platelet aggregation	IMP IMP: 通过突变表型推断	26045608	MGI
acts upstream of or within positive regulation of chondrocyte proliferation	IMP IMP: 通过突变表型推断	17307734	MGI
involved in protein homooligomerization	IDA IDA: 通过直接分析推断	32747625	MGI
acts upstream of or within protein processing	IMP IMP: 通过突变表型推断	26045608	MGI
acts upstream of or within protein secretion	IMP IMP: 通过突变表型推断	26746240	MGI
acts upstream of or within regulation of bone mineralization	IMP IMP: 通过突变表型推断	21350216	MGI
acts upstream of or within regulation of gene expression	IMP IMP: 通过突变表型推断	22006726	MGI
acts upstream of or within response to unfolded protein	IMP IMP: 通过突变表型推断	17588960	MGI
acts upstream of or within skeletal system development	IGI IGI: 通过遗传相互作用推断	18191556	MGI
acts upstream of or within skin development	IMP IMP: 通过突变表型推断	26746240	MGI
acts upstream of or within tendon development	IMP IMP: 通过突变表型推断	19808781	MGI
acts upstream of or within vascular associated smooth muscle cell development	IMP IMP: 通过突变表型推断	21350216	MGI
acts upstream of or within vascular associated smooth muscle contraction	IMP IMP: 通过突变表型推断	27498005	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular region	IDA IDA: 通过直接分析推断	32747625	MGI
located in extracellular space	IDA IDA: 通过直接分析推断	17588960	MGI
part of protein-containing complex	IDA IDA: 通过直接分析推断	26045608	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

cartilage oligomeric matrix protein

thrombospondin-5

Comp 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	Comp	Q9R0G6	ADAMTS12	Homo sapiens	P58397	ELISA	16611630
种属间	Comp	Q9R0G6	ADAMTS12	Homo sapiens	P58397	Pull Down	16611630

种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase

生物活性分子 (42)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-153991	STAT6-IN-2	Inhibitor	99.85%	否
HY-160497	MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885		99.63%	否
HY-138569	HPK1-IN-4	Inhibitor	99.42%	否
HY-156592A	ROCK2-IN-6 hydrochloride	Inhibitor	99.95%	否
HY-163573	FANCM-BTR PPI-IN-1		96.17%	否
HY-164788	GGFG-PAB-MMAE	Inhibitor	/	否
HY-125222	Drp1-IN-1	Inhibitor	98.02%	否
HY-153413	Kras4B G12D-IN-1	Inhibitor	98.01%	否
HY-153473	FLT3-IN-19	Inhibitor	99.19%	否
HY-N12492	11,12-Di-O-methylcarnosol		/	否
HY-136806	PI3K-IN-12	Inhibitor	/	否
HY-138993	NNMT-IN-6	Inhibitor	/	否
HY-139252	Anticancer agent 225	Inducer	/	否
HY-139292	Fmoc-NH-PEG6-alcohol		/	否
HY-139595	Polyketide synthase 13-IN-2	Inhibitor	/	否
HY-145775	hIgG-hFc receptor-IN-1	Inhibitor	/	否
HY-145865	c-Met/MEK1/Flt-3-IN-1	Inducer	/	否
HY-145866	Antiproliferative agent-3	Inhibitor	/	否
HY-145888	Antioxidant agent-2	Inhibitor	/	否
HY-145896	Anti-osteoporosis agent-1	Inhibitor	/	否
HY-149891	HSP90-IN-23	Inhibitor	/	否
HY-150268	BET-IN-16	Inhibitor	/	否
HY-153002	p38α inhibitor 3	Inhibitor	99.82%	否
HY-153277	Axl/Mer/CSF1R-IN-2	Inhibitor	/	否
HY-153739	N3-PEG3-VC-PAB-MMAF		/	否
HY-153914	B-Raf IN 14	Inhibitor	/	否
HY-153930	h15-LOX-2 inhibitor 1	Inhibitor	/	否
HY-153989	SOS1-IN-16	Inhibitor	/	否
HY-155610	VEGFR-2-IN-32	Inhibitor	/	否
HY-156566	PROTAC BRD4 Degrader-21	Inhibitor	/	否
HY-156592	ROCK2-IN-6	Inhibitor	/	否
HY-156670	Camptothecin analog-1		/	否
HY-156875	20-HETE inhibitor-1	Inhibitor	/	否
HY-158326	FAP-IN-4	Inhibitor	/	否
HY-160545	NLRP3-IN-31	Inhibitor	/	否
HY-163569	FGFR4-IN-20	Inhibitor	/	否
HY-164560	MALT1-IN-14	Inhibitor	/	否
HY-P10723	IL-23R inhibitor peptide-1	Inhibitor	/	否
HY-RS03015	COMP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-119648A	(E/Z)-CCR-11	Inhibitor	98.00%	否
HY-138110	Toladryl	Antagonist	/	否
HY-139223	pEBOV-IN-1	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Comp	NCBI	NCBI:1311
Macaca fascicularis	Comp	NCBI	NCBI:101867220
Susscrofa domestica	Comp	NCBI
Rattus norvegicus	Comp	NCBI	NCBI:25304
Macaca mulatta	Comp	NCBI	NCBI:720286

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