2. Gene
  3. Cdh1 - cadherin 1 Gene

Cdh1 - cadherin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 83502 | 基因类型: protein coding

关于 Cdh1

功能概要

Predicted to enable several functions, including GTPase activating protein binding activity; alpha-catenin binding activity; and ankyrin binding activity. Involved in several processes, including nervous system development; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; and response to toxic substance. Located in cytoplasm and plasma membrane. Is active in glutamatergic synapse and postsynapse. Used to study hepatocellular carcinoma and lung adenocarcinoma. Biomarker of pulmonary fibrosis and urinary bladder Cancer. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast Cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system Cancer (multiple); and reproductive organ Cancer (multiple). Orthologous to human CDH1 (cadherin 1). [provided by Alliance of Genome Resources, Apr 2022]

Cdh1 基因产物(1)

mRNA Protein Name
NM_031334.1 NP_112624.1 cadherin-1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-catenin binding IPI
IPI: 通过物理相互作用推断
12960056 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12639940 RGD
enables protein tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
12700184 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of axon extension IMP
IMP: 通过突变表型推断
23226367 RGD
involved in neuron projection development IEP
IEP: 通过表达模式推断
12387456 RGD
involved in pituitary gland development IEP
IEP: 通过表达模式推断
17373711 RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IDA
IDA: 通过直接分析推断
21186356 RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IEP
IEP: 通过表达模式推断
21186356 RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IMP
IMP: 通过突变表型推断
21186356 RGD
involved in response to Gram-positive bacterium IEP
IEP: 通过表达模式推断
20501441 RGD
involved in response to heparin IEP
IEP: 通过表达模式推断
16997938 RGD
involved in response to toxic substance IEP
IEP: 通过表达模式推断
17120308 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
16671876 RGD
involved in synapse assembly IMP
IMP: 通过突变表型推断
12123610 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
21186356 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
21186356 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
21186356 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cadherin-1

E-cadherin

epithelial cadherin

uvomorulin

重组 Cdh1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74367 Cadherin-1/CD324 Protein, Rat (HEK293, His) Q9R0T4 (Q24-A713) ≥95%
HY-P74368 Cadherin-1/CD324 Protein, Rat (HEK293, Fc) Q9R0T4 (Q24-A713) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13067 Celastrol 99.90% 否
HY-13255 TAME Inhibitor 99.51% 否
HY-13255A TAME hydrochloride Inhibitor 98.31% 否
HY-RS02320 CDH1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-145268 SLEC-11 Inhibitor / 否
HY-145269 AL-GDa62 Inhibitor / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990362 Anti-CDH1/E-cadherin/CD324 Antibody / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cdh1 NCBI NCBI:999
Macaca fascicularis Cdh1 NCBI NCBI:102143513
Mus musculus Cdh1 NCBI NCBI:12550
Macaca mulatta Cdh1 NCBI NCBI:704387
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