2. Gene
  3. Cdh1 - cadherin 1 Gene

Cdh1 - cadherin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Um; UVO; Ecad; ARC-1; E-cad; L-CAM

基因 ID: 12550 | 基因类型: protein coding

关于 Cdh1

功能概要

This gene encodes E-cadherin, a calcium-dependent cell adhesion molecule that functions in the establishment and maintenance of epithelial cell morphology during embryongenesis and adulthood. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Targeted mutations disrupting binding of calcium to the encoded protein in mice cause death in utero due to failed blastocyst and trophectoderm formation. This gene is located adjacent to a related cadherin gene on chromosome 8. [provided by RefSeq, Oct 2015]

Cdh1 基因产物(1)

mRNA Protein Name
NM_009864.3 NP_033994.1 cadherin-1 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables alpha-catenin binding IPI
IPI: 通过物理相互作用推断
8853988 MGI
enables beta-catenin binding IDA
IDA: 通过直接分析推断
7806582 MGI
enables beta-catenin binding IPI
IPI: 通过物理相互作用推断
8853988 MGI
enables calcium ion binding IDA
IDA: 通过直接分析推断
12460580 MGI
enables cytoskeletal protein binding IMP
IMP: 通过突变表型推断
2519616 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
12460580 MGI
enables molecular adaptor activity EXP
EXP: 通过实验结果推断
11121423 MGI
enables molecular adaptor activity IDA
IDA: 通过直接分析推断
11121423 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9531566 MGI
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
18794329 MGI
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
16973135 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within actin cytoskeleton organization IMP
IMP: 通过突变表型推断
17507657 MGI
acts upstream of or within bicellular tight junction assembly IMP
IMP: 通过突变表型推断
15775979 MGI
acts upstream of or within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: 通过直接分析推断
15023525 MGI
acts upstream of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
22766025 MGI
acts upstream of or within cell-cell adhesion IMP
IMP: 通过突变表型推断
15148305 MGI
acts upstream of or within cell-cell adhesion mediated by cadherin IMP
IMP: 通过突变表型推断
17507657 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: 通过直接分析推断
20548288 MGI
involved in cochlea development IDA
IDA: 通过直接分析推断
30639848 MGI
acts upstream of or within cochlea development IMP
IMP: 通过突变表型推断
21925491 MGI
involved in decidualization IMP
IMP: 通过突变表型推断
22378759 MGI
involved in embryo implantation IMP
IMP: 通过突变表型推断
22378759 MGI
acts upstream of or within epithelial cell morphogenesis IMP
IMP: 通过突变表型推断
22766025 MGI
acts upstream of or within establishment of skin barrier IMP
IMP: 通过突变表型推断
15775979 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
15775979 MGI
acts upstream of or within intestinal epithelial cell development IMP
IMP: 通过突变表型推断
22766025 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
22766025 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
22766025 MGI
acts upstream of or within negative regulation of protein localization to plasma membrane IMP
IMP: 通过突变表型推断
17507657 MGI
acts upstream of or within negative regulation of protein processing IMP
IMP: 通过突变表型推断
17344476 MGI
acts upstream of or within positive regulation of cell-cell adhesion IMP
IMP: 通过突变表型推断
2519616 MGI
involved in protein localization to plasma membrane IDA
IDA: 通过直接分析推断
7806582 MGI
acts upstream of or within regulation of branching involved in salivary gland morphogenesis IMP
IMP: 通过突变表型推断
18816447 MGI
acts upstream of or within regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
15192701 MGI
acts upstream of or within regulation of neuron migration IDA
IDA: 通过直接分析推断
23434913 MGI
acts upstream of or within regulation of protein localization IMP
IMP: 通过突变表型推断
15775979 MGI
acts upstream of or within regulation of protein localization to cell surface IMP
IMP: 通过突变表型推断
15775979 MGI
acts upstream of or within salivary gland cavitation IMP
IMP: 通过突变表型推断
18816447 MGI
acts upstream of or within sensory perception of sound IMP
IMP: 通过突变表型推断
21925491 MGI
acts upstream of or within trophectodermal cell differentiation IMP
IMP: 通过突变表型推断
17138661 MGI
involved in uterine epithelium development IMP
IMP: 通过突变表型推断
22378759 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Schmidt-Lanterman incisure IDA
IDA: 通过直接分析推断
20237282 MGI
located in adherens junction IDA
IDA: 通过直接分析推断
8582267 MGI
located in apical junction complex IDA
IDA: 通过直接分析推断
17130295 MGI
located in apical part of cell IDA
IDA: 通过直接分析推断
14758363 MGI
located in axon IDA
IDA: 通过直接分析推断
17392463 MGI
located in axon terminus IDA
IDA: 通过直接分析推断
17392463 MGI
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
15788452 MGI
part of catenin complex IDA
IDA: 通过直接分析推断
8853988 MGI
part of catenin complex IMP
IMP: 通过突变表型推断
11121423 MGI
located in cell periphery IDA
IDA: 通过直接分析推断
19289495 MGI
located in cell surface IDA
IDA: 通过直接分析推断
11511678 MGI
located in cell-cell junction IDA
IDA: 通过直接分析推断
9864371 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
23637336 MGI
part of flotillin complex IDA
IDA: 通过直接分析推断
24046456 MGI
located in lateral loop IDA
IDA: 通过直接分析推断
20237282 MGI
located in microvillus IDA
IDA: 通过直接分析推断
33129760 MGI
located in node of Ranvier IDA
IDA: 通过直接分析推断
20237282 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
8853988 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cadherin-1

E-cadherin

epithelial cadherin

uvomorulin

重组 Cdh1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700008 Cadherin-1/CD324 Protein, Mouse (HEK293, C-His) P09803 (D157-V709) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13067 Celastrol 99.90% 否
HY-13255 TAME Inhibitor 99.51% 否
HY-13255A TAME hydrochloride Inhibitor 98.31% 否
HY-145268 SLEC-11 / 否
HY-145269 AL-GDa62 / 否
HY-RS02320 CDH1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cdh1 NCBI NCBI:999
Macaca fascicularis Cdh1 NCBI NCBI:102143513
Rattus norvegicus Cdh1 NCBI NCBI:83502
Macaca mulatta Cdh1 NCBI NCBI:704387
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