2. Gene
  3. Mchr1 - melanin-concentrating hormone receptor 1 Gene

Mchr1 - melanin-concentrating hormone receptor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：黑色素浓缩激素受体 1

种属: Rattus norvegicus

同用名: Slc1; Gpr24; Mch-1r

基因 ID: 83567 | 基因类型: protein coding

关于 Mchr1

Primary_assembly 7: 112,761,554-112,764,032 forward strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 241 orthologues, 50 paralogues and is associated with 3 phenotypes. Biased expression in Brain (RPKM 31.9), Muscle (RPKM 4.3) and 2 other tissues.

功能概要

该基因编码的蛋白可启动激素结合活动；黑色素浓缩激素受体活性；和蛋白质 C 末端结合活性。参与细胞表面受体信号通路；正调节钙离子运输；和细胞溶质钙离子浓度的正调节。位于质膜。肥胖的生物标志物。该基因的人类直系同源物与病态肥胖有关。与人类 MCHR1（黑色素浓缩激素受体 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables hormone binding activity; melanin-concentrating hormone receptor activity; and protein C-terminus binding activity. Involved in cell surface receptor signaling pathway; positive regulation of calcium ion transport; and positive regulation of cytosolic calcium ion concentration. Located in plasma membrane. Biomarker of obesity. Human ortholog(s) of this gene implicated in morbid obesity. Orthologous to human MCHR1 (melanin concentrating hormone receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Mchr1 基因产物(1)

mRNA Protein Name
NM_031758.1 NP_113946.1 melanin-concentrating hormone receptor 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables hormone binding IDA
IDA: 通过直接分析推断
12505154 RGD
enables melanin-concentrating hormone receptor activity IDA
IDA: 通过直接分析推断
12505154 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
16945926 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell surface receptor signaling pathway IMP
IMP: 通过突变表型推断
15117878 RGD
involved in positive regulation of calcium ion transport IMP
IMP: 通过突变表型推断
15117878 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
10559938 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Mchr1 蛋白结构

7tmA_MCHR1

7tmA_MCHR1: cd15338 (40 - 321)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (41 - 67)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (77 - 103)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (115 - 145)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (157 - 177)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (204 - 233)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (248 - 278)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (289 - 314)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
蛋白主名 其他名称

melanin-concentrating hormone receptor 1

G-protein coupled receptor 24

MCH receptor 1

MCH-R1

MCH1R

MCHR

MCHR-1

SLC-1

somatostatin receptor-like protein

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-U00257 AZD1979 Antagonist 98.09% Phase 1
Pre-clinical Phase
生物活性分子 (19)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-107625A SNAP 94847 hydrochloride Inhibitor 99.90% 否
HY-P1204 [Ala17]-MCH Agonist 98.28% 否
HY-100321 MCHR1 antagonist 2 98.27% 否
HY-101699 AMG-076 free base Antagonist / 否
HY-107625 SNAP 94847 Antagonist / 否
HY-107626 ATC0065 Antagonist / 否
HY-107626A ATC0065 free base Antagonist / 否
HY-116031 ATC0175 free base Antagonist / 否
HY-120608 BMS-814580 Inhibitor / 否
HY-136152 MCHR1 antagonist 3 Antagonist / 否
HY-161899 MCHR1 antagonist 4 Antagonist / 否
HY-P1204A [Ala17]-MCH TFA Agonist / 否
HY-RS08225 MCHR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08226 Mchr1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08227 Mchr1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-101699A AMG-076 Antagonist / 否
HY-12433 BMS-819881 / 否
HY-100318 NGD-4715 Antagonist / 否
HY-U00353 MCHR1 antagonist 1 Antagonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mchr1 NCBI NCBI:2847
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