1. Gene
  2. Mchr1 - melanin-concentrating hormone receptor 1 Gene

Mchr1 - melanin-concentrating hormone receptor 1 Gene

中文名称:黑色素浓缩激素受体 1

种属: Rattus norvegicus

同用名: Slc1; Gpr24; Mch-1r

基因 ID: 83567 | 基因类型: protein coding

关于 Mchr1

Primary_assembly 7: 112,761,554-112,764,032 forward strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 241 orthologues, 50 paralogues and is associated with 3 phenotypes. Biased expression in Brain (RPKM 31.9), Muscle (RPKM 4.3) and 2 other tissues.

功能概要

该基因编码的蛋白可启动激素结合活动;黑色素浓缩激素受体活性;和蛋白质 C 末端结合活性。参与细胞表面受体信号通路;正调节钙离子运输;和细胞溶质钙离子浓度的正调节。位于质膜。肥胖的生物标志物。该基因的人类直系同源物与病态肥胖有关。与人类 MCHR1(黑色素浓缩激素受体 1)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables hormone binding activity; melanin-concentrating hormone receptor activity; and protein C-terminus binding activity. Involved in cell surface receptor signaling pathway; positive regulation of calcium ion transport; and positive regulation of cytosolic calcium ion concentration. Located in plasma membrane. Biomarker of obesity. Human ortholog(s) of this gene implicated in morbid obesity. Orthologous to human MCHR1 (melanin concentrating hormone receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Mchr1 基因产物(1)

mRNA Protein Name
NM_031758.1 NP_113946.1 melanin-concentrating hormone receptor 1

Mchr1 蛋白结构

7tmA_MCHR1

7tmA_MCHR1: cd15338 (40 - 321)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (41 - 67)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (77 - 103)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (115 - 145)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (157 - 177)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (204 - 233)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (248 - 278)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (289 - 314)

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  • 353 a.a.
蛋白主名 其他名称

melanin-concentrating hormone receptor 1

G-protein coupled receptor 24

MCH receptor 1

MCH-R1

MCH1R

MCHR

MCHR-1

SLC-1

somatostatin receptor-like protein

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mchr1 NCBI NCBI:2847