2. Gene
  3. CASP6 - caspase 6 Gene

CASP6 - caspase 6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：半胱天冬酶 6

种属: Rattus norvegicus

同用名: Mch2

基因 ID: 83584 | 基因类型: protein coding

关于 CASP6

Primary_assembly 2: 218,466,076-218,478,502 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 268 orthologues, 12 paralogues and is associated with 16 phenotypes. Biased expression in Thymus (RPKM 132.6), Liver (RPKM 128.) and 9 other tissues.

功能概要

该基因编码的蛋白可启动内肽酶活性。参与多个过程，包括对非抗原刺激的急性炎症反应；轴突束缚；和程序性细胞死亡的正调节。位于多个细胞成分中，包括轴突；胞质溶胶；和神经细胞体。用于研究癫痫持续状态。脑缺血的生物标志物；子宫内膜炎;大脑中动脉梗塞;和前列腺癌。该基因的人类直系同源物与卵巢癌有关。与人类 CASP6（caspase 6）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables endopeptidase activity. Involved in several processes, including acute inflammatory response to non-antigenic stimulus; axonal fasciculation; and positive regulation of programmed cell death. Located in several cellular components, including axon; cytosol; and neuronal cell body. Used to study status epilepticus. Biomarker of brain ischemia; endometritis; middle cerebral artery infarction; and prostate carcinoma. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CASP6 (Caspase 6). [provided by Alliance of Genome Resources, Apr 2022]

CASP6 基因产物(2)

mRNA Protein Name
NM_001271984.1 NP_001258913.1 caspase-6
NM_031775.3 NP_113963.2 caspase-6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables endopeptidase activity IDA
IDA: 通过直接分析推断
12081569 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acute inflammatory response to non-antigenic stimulus IDA
IDA: 通过直接分析推断
18175566 RGD
involved in axonal fasciculation IMP
IMP: 通过突变表型推断
25898930 RGD
involved in lens development in camera-type eye IEP
IEP: 通过表达模式推断
15161922 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
12606487 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
11433428 RGD
involved in positive regulation of retinal cell programmed cell death IMP
IMP: 通过突变表型推断
12917395 RGD
involved in response to cytokine IDA
IDA: 通过直接分析推断
15201138 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
12967350 RGD
involved in response to gamma radiation IEP
IEP: 通过表达模式推断
10590178 RGD
involved in response to glucose IMP
IMP: 通过突变表型推断
12606487 RGD
involved in response to hydrogen peroxide IDA
IDA: 通过直接分析推断
17571084 RGD
involved in response to iron ion IMP
IMP: 通过突变表型推断
17571084 RGD
involved in response to metal ion IEP
IEP: 通过表达模式推断
11960910 RGD
involved in response to testosterone IEP
IEP: 通过表达模式推断
12724284 RGD
involved in response to toxic substance IEP
IEP: 通过表达模式推断
16733813 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
25898930 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
25898930 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CASP6 蛋白结构

CASc

CASc: smart00115 (19 - 272)

  • 0
  • 100
  • 200
  • 277 a.a.
蛋白主名 其他名称

caspase-6

CASP-6

apoptotic protease Mch-2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01959 CASP6 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01960 Casp6 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01961 CASP6 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens CASP6 NCBI NCBI:839
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