2. Gene
  3. Plk2 - polo-like kinase 2 Gene

Plk2 - polo-like kinase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：马球样激酶 2

种属: Rattus norvegicus

同用名: Snk

基因 ID: 83722 | 基因类型: protein coding

关于 Plk2

Primary_assembly 2: 41,969,176-41,974,947 forward strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 221 orthologues, 4 paralogues and is associated with 8 phenotypes. Biased expression in Brain (RPKM 389.), Liver (RPKM 239.2) and 9 other tissues.

功能概要

该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸激酶活性。参与多个过程，包括Rap蛋白信号转导；树突棘发育的负调节；和突触可塑性的调节。位于树突中。与人类 PLK2（马球样激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein serine/threonine kinase activity. Involved in several processes, including Rap protein signal transduction; negative regulation of dendritic spine development; and regulation of synaptic plasticity. Located in dendrite. Orthologous to human PLK2 (polo like kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Plk2 基因产物(1)

mRNA Protein Name
NM_031821.2 NP_114009.1 serine/threonine-protein kinase PLK2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATPase binding IPI
IPI: 通过物理相互作用推断
20802490 RGD
enables GTPase binding IPI
IPI: 通过物理相互作用推断
20802490 RGD
enables clathrin heavy chain binding IPI
IPI: 通过物理相互作用推断
20802490 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10523297 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
20802490 RGD
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
18498738 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
18723513 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Rap protein signal transduction IDA
IDA: 通过直接分析推断
21382555 RGD
involved in Ras protein signal transduction IDA
IDA: 通过直接分析推断
21382555 RGD
involved in long-term synaptic depression IDA
IDA: 通过直接分析推断
21382555 RGD
involved in long-term synaptic potentiation IDA
IDA: 通过直接分析推断
21382555 RGD
involved in negative regulation of dendritic spine development IMP
IMP: 通过突变表型推断
18723513 RGD
involved in negative regulation of excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
20802490 RGD
involved in negative regulation of protein localization to cell surface IMP
IMP: 通过突变表型推断
20802490 RGD
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
18723513 RGD
involved in positive regulation of receptor internalization IMP
IMP: 通过突变表型推断
20802490 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
21382555 RGD
involved in regulation of synaptic plasticity IDA
IDA: 通过直接分析推断
21382555 RGD
involved in regulation of synaptic plasticity IMP
IMP: 通过突变表型推断
18498738 RGD
involved in regulation protein catabolic process at postsynapse IDA
IDA: 通过直接分析推断
14576440 RGD
involved in regulation protein catabolic process at postsynapse IEP
IEP: 通过表达模式推断
14576440 RGD
involved in regulation protein catabolic process at postsynapse IMP
IMP: 通过突变表型推断
14576440 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite IDA
IDA: 通过直接分析推断
10523297 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
14576440 RGD
is active in postsynapse IMP
IMP: 通过突变表型推断
14576440 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Plk2 蛋白结构

STKc_PLK2

STKc_PLK2: cd14188 (76 - 330)

POLO_box_1

POLO_box_1: cd13118 (499 - 584)

POLO_box_2

POLO_box_2: cd13117 (597 - 678)

  • 0
  • 200
  • 400
  • 600
  • 682 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase PLK2

PLK-2

polo-like kinase 1

serine/threonine-protein kinase SNK

serum-inducible kinase

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-12137 Volasertib Inhibitor 99.87% 是
HY-12137A Volasertib trihydrochloride Inhibitor / 否
Clinical Phase
生物活性分子 (7)
目录号 产品名 作用方式
纯度 Phase
HY-12037A Rigosertib Inhibitor 99.01% Phase 3
HY-12037 Rigosertib sodium Inhibitor 99.57% Phase 3
HY-50698 BI 2536 Inhibitor 99.95% Phase 2
HY-147298 Plogosertib Inhibitor 99.95% Phase 2
HY-15160 TAK-960 Inhibitor 99.75% Phase 1
HY-15160B TAK-960 dihydrochloride Inhibitor 99.19% Phase 1
HY-15160A TAK-960 hydrochloride Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100789 ON1231320 Inhibitor 99.24% 否
HY-108597 TC-S 7005 Inhibitor 99.68% 否
HY-12134 Poloxin Inhibitor 98.01% 否
HY-149100 PLK1-IN-6 Inhibitor / 否
HY-115589 YLT-11 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Plk2 NCBI NCBI:10769
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z