2. Gene
  3. STARD3NL - STARD3 N-terminal like Gene

STARD3NL - STARD3 N-terminal like Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：STARD3 N 端类

种属: Homo sapiens

同用名: MENTHO

基因 ID: 83930 | 基因类型: protein coding

关于 STARD3NL

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:38,178,245-38,230,669 (from NCBI)

This gene has 7 transcripts (splice variants), 219 orthologues and 5 paralogues. Ubiquitous expression in prostate (RPKM 17.0), placenta (RPKM 15.5) and 25 other tissues.

功能概要

该基因编码含有保守 MENTAL (MLN64 N 末端) 结构域的晚期内体蛋白。编码的蛋白质结合胆固醇分子，并可能通过与转移性淋巴结蛋白 64 (MLN64) 的相互作用在内体胆固醇转运中发挥作用。[RefSeq 提供，2011 年 9 月]

This gene encodes a late-endosomal protein that contains a conserved MENTAL (MLN64 N-terminal) domain. The encoded protein binds Cholesterol molecules and may play a role in endosomal Cholesterol transport through interactions with metastatic lymph node protein 64 (MLN64). [provided by RefSeq, Sep 2011]

STARD3NL 基因产物(8)

mRNA Protein Name
NM_001363339.2 NP_001350268.1 STARD3 N-terminal-like protein isoform 1
NM_001363340.2 NP_001350269.1 STARD3 N-terminal-like protein isoform 1
NM_001363343.2 NP_001350272.1 STARD3 N-terminal-like protein isoform 2
NM_001363344.2 NP_001350273.1 STARD3 N-terminal-like protein isoform 2
NM_001363345.2 NP_001350274.1 STARD3 N-terminal-like protein isoform 2
NM_001363346.2 NP_001350275.1 STARD3 N-terminal-like protein isoform 2
NM_001363347.2 NP_001350276.1 STARD3 N-terminal-like protein isoform 2
NM_032016.4 NP_114405.1 STARD3 N-terminal-like protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cholesterol binding IDA
IDA: 通过直接分析推断
15718238 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15718238 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
15718238 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in vesicle tethering to endoplasmic reticulum IDA
IDA: 通过直接分析推断
24105263 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
24105263 GOA
located in endoplasmic reticulum-endosome membrane contact site IDA
IDA: 通过直接分析推断
24105263 GOA
located in endosome IDA
IDA: 通过直接分析推断
29858488 GOA
located in late endosome membrane IDA
IDA: 通过直接分析推断
24105263 GOA
located in organelle membrane contact site IDA
IDA: 通过直接分析推断
24105263 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STARD3NL 蛋白结构

MENTAL

MENTAL: Cholesterol-capturing domain (49 - 215)

  • 0
  • 100
  • 200
  • 234 a.a.
蛋白主名 其他名称

STARD3 N-terminal-like protein

MLN64 N-terminal domain homolog

STARD3NL 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
STARD3NL O95772 HCST Homo sapiens Q9UBK5
Y2H Prey Pooling
32296183
种属内
STARD3NL O95772 HCST Homo sapiens Q9UBK5
Validated Y2H
32296183
种属内
STARD3NL O95772 HCST Homo sapiens Q9UBK5
Y2H Array
32296183
种属内
STARD3NL O95772 MOSPD2 Homo sapiens Q8NHP6
Anti Tag CoIP
29858488
种属内
STARD3NL O95772 MOSPD2 Homo sapiens Q8NHP6
Pull Down
29858488
种属内
STARD3NL O95772 MOSPD2 Homo sapiens Q8NHP6
Anti Tag CoIP
33961781
种属内
STARD3NL O95772 MOSPD2 Homo sapiens Q8NHP6
Confocal
29858488
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Immunodeficiency 51

IMD51

Candf5

Candidiasis, Familial, 5

Candidiasis, Familial, 5, Formerly

Candf5, Formerly

Familial Candidiasis 5

Candidiasis Familial 5 Autosomal Recessive

Candidiasis Familial Chronic Mucocutaneous Autosomal Recessive

Chronic Mucocutaneous Candidiasis 5
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13879 STARD3NL Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus STARD3NL VGNC VGNC:35364
Canis familiaris STARD3NL VGNC VGNC:46883
Macaca mulatta STARD3NL VGNC VGNC:84755
Felis catus STARD3NL VGNC VGNC:65754
Rattus norvegicus STARD3NL RGD RGD:1308633
Mus musculus STARD3NL MGD MGI:1923455
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