Ikbkb - inhibitor of nuclear factor kappa B kinase subunit beta Gene

中文名称：核因子 κB 激酶亚基 β 抑制因子

种属: Rattus norvegicus

同用名: IKK2; AIM-1

关于 Ikbkb

功能概要

该基因编码的蛋白可启动 ATP 绑定活动。有助于 IkappaB 激酶活性。参与多个过程，包括 NF-kappaB 转录因子活性的正调控；对胆囊收缩素的反应；和对脂多糖的反应。位于胞质溶胶和胞内膜界的细胞器中。 IkappaB 激酶复合体的一部分。用于研究肌肉萎缩和肺炎。阿尔茨海默病的生物标志物；结肠炎;结肠癌;高血压;和短暂性脑缺血。该基因与乳腺癌相关的人类直向同源基因；联合免疫缺陷（多种）；皮炎;前列腺癌（多发）；和 2 型糖尿病。与人 IKBKB（核因子 kappa B 激酶亚基 β 抑制剂）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity. Contributes to IkappaB kinase activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; response to cholecystokinin; and response to lipopolysaccharide. Located in cytosol and intracellular membrane-bounded organelle. Part of IkappaB kinase complex. Used to study muscular atrophy and pneumonia. Biomarker of Alzheimer's disease; colitis; colon cancer; hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in breast cancer; combined immunodeficiency (multiple); dermatitis; prostate Cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]