2. Gene
  3. ACRBP - acrosin binding protein Gene

ACRBP - acrosin binding protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：顶体结合蛋白

种属: Homo sapiens

同用名: CT23; SP32; OY-TES-1

基因 ID: 84519 | 基因类型: protein coding

关于 ACRBP

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,638,075-6,647,432 (from NCBI)

This gene has 9 transcripts (splice variants) and 118 orthologues. Restricted expression toward testis (RPKM 162.2).

功能概要

由该基因编码的蛋白质类似于在小鼠、豚鼠和猪中发现的前顶体蛋白结合蛋白 sp32 前体。这种蛋白质位于精子顶体中，被认为作为顶体基质中顶体蛋白酶原包装和缩合的顶体蛋白原的结合蛋白。这种蛋白质是癌症/睾丸抗原家族的成员，被发现具有免疫原性。在正常组织中，这种 mRNA 仅在睾丸中表达，而在一系列不同的肿瘤类型 (如膀胱、乳腺、肺、肝和结肠) 中检测到。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the Cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. [provided by RefSeq, Jul 2008]

ACRBP 基因产物(1)

mRNA Protein Name
NM_032489.3 NP_115878.2 acrosin-binding protein precursor

ACRBP 蛋白结构

PBP_sp32

PBP_sp32: Proacrosin binding protein sp32 (1 - 240)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 543 a.a.
蛋白主名 其他名称

acrosin-binding protein

acrosin-binding protein, 60 kDa form

关联疾病

疾病名称 别名
Brain Cancer

Adult Brain Tumor

Malignant Neoplasm Of Brain

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary
Cataract 9, Multiple Types

Cataract 9 Multiple Types

CTRCT9

Cataract, Autosomal Dominant

Catc1

Cataract 9, Multiple Types, With Or Without Microcornea

Cataract, Autosomal Recessive Congenital 1

Autosomal Recessive Congenital Cataract 1

Cataract 9 Multiple Types With Or Without Microcornea

Autosomal Dominant Congenital Cataract

Cataract Autosomal Dominant

Cataracts, Autosomal Dominant
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00194 ACRBP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ACRBP VGNC VGNC:69445
Canis familiaris ACRBP VGNC VGNC:37527
Mus musculus ACRBP MGD MGI:1859515
Bos taurus ACRBP VGNC VGNC:25558
Felis catus ACRBP VGNC VGNC:59530
Rattus norvegicus ACRBP RGD RGD:1564880
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