HOPX - HOP homeobox Gene

中文名称：HOP 同源框

种属: Homo sapiens

同用名: HOD; HOP; OB1; LAGY; TOTO; CAMEO; NECC1; SMAP31

基因 ID: 84525 | 基因类型: protein coding

关于 HOPX

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:56,647,998-56,681,706 (from NCBI)

This gene has 15 transcripts (splice variants) and 167 orthologues. Biased expression in skin (RPKM 80.6), esophagus (RPKM 62.3) and 8 other tissues.

功能概要

该基因编码的蛋白质是一种同源域蛋白质，缺少 DNA 结合所需的某些保守残基。据报道，绒癌细胞系和组织未能表达该基因，提示该基因可能参与胎盘滋养细胞的恶性转化。小鼠研究表明，这种蛋白质可能与血清反应因子 (SRF) 相互作用并调节 SRF 依赖性心脏特异性基因表达和心脏发育。已为该基因鉴定出多个选择性剪接的转录物变体。[RefSeq 提供，2009 年 2 月]

The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009]

HOPX 基因产物(5)

mRNA	Protein	Name
NM_001145459.2	NP_001138931.1	homeodomain-only protein isoform b
NM_001145460.2	NP_001138932.1	homeodomain-only protein isoform c
NM_032495.6	NP_115884.4	homeodomain-only protein isoform a
NM_139211.5	NP_631957.1	homeodomain-only protein isoform b
NM_139212.4	NP_631958.1	homeodomain-only protein isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in chaperone-mediated protein complex assembly	IDA IDA: 通过直接分析推断	10811660	GOA
acts upstream of or within negative regulation of cell differentiation	IDA IDA: 通过直接分析推断	17576768	GOA
acts upstream of or within trophectodermal cell differentiation	IDA IDA: 通过直接分析推断	17576768	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	17192267	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HOPX 蛋白结构

Homeobox

0
73 a.a.

蛋白主名

其他名称

homeodomain-only protein

lung cancer-associated Y protein

HOPX 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HOPX	Q9BPY8	TCF12	Homo sapiens	Q99081	Validated Y2H	25416956
种属内	HOPX	Q9BPY8	TCF12	Homo sapiens	Q99081	Y2H Array	25416956
种属内	HOPX	Q9BPY8	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
种属内	HOPX	Q9BPY8	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
种属内	HOPX	Q9BPY8	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Choriocarcinoma

Chorioepithelioma

Mesenteric Vascular Occlusion

Squamous Cell Carcinoma

Epidermoid Carcinoma	Squamous Cell Cancer
Carcinoma, Squamous Cell	Squamous Cell Skin Cancer
Malignant Squamous Cell Tumor	Squamous Carcinoma
Squamous Cell Epithelioma	Carcinoma Squamous Cell
Neoplasms, Squamous Cell	Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm	Squamous Cell Carcinoma Of Skin

Oral Squamous Cell Carcinoma

Mouth Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Mouth

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Hemophagocytic Lymphohistiocytosis, Familial, 1

Familial Hemophagocytic Lymphohistiocytosis	Fhl
Familial Erythrophagocytic Lymphohistiocytosis	Hemophagocytic Syndrome
FHL1	Hplh1
Hlh1	Fel
Familial Hemophagocytic Lymphohistiocytosis 1	Primary Hemophagocytic Lymphohistiocytosis
Familial Hlh	Hlh
Familial Hemophagocytic Lymphocytosis	Hemophagocytic Lymphohistiocytosis, Familial
Reticulosis, Familial Histiocytic	Hemophagocytic Reticulosis, Familial
Erythrophagocytic Lymphohistiocytosis, Familial	Familial Histiocytic Reticulosis
Familial Hemophagocytic Histiocytosis	Familial Hemophagocytic Reticulosis
Fhlh	Hplh
Primary Hemophagocytic Hymphohistiocytosis	Genetic Hemophagocytic Lymphohistiocytosis
Hemophagocytic Lymphohistiocytosis	Familial Hemophagocytic Lymphohistiocytosis Type 1

Melanoma, Cutaneous Malignant 1

Familial Melanoma	Melanoma, Cutaneous Malignant, Susceptibility To, 1
Melanoma, Malignant	CMM1
Melanoma, Cutaneous Malignant	Cmm
Familial Atypical Mole-Malignant Melanoma Syndrome	Fammm
Melanoma, Familial	Mlm
Dysplastic Nevus Syndrome, Hereditary	Dns
B-K Mole Syndrome	Melanoma, Cutaneous Malignant, 1
Malignant Melanoma, Cutaneous	Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1
Dysplastic Nevus Syndrome	Cutaneous Melanoma
Familial Atypical Mole Melanoma Syndrome	Hereditary Melanoma

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06290	HOPX Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	HOPX	VGNC	VGNC:78509
Bos taurus	HOPX	VGNC	VGNC:29907
Rattus norvegicus	HOPX	RGD	RGD:621841
Macaca mulatta	HOPX	VGNC	VGNC:73438
Canis familiaris	HOPX	VGNC	VGNC:41743
Mus musculus	HOPX	MGD	MGI:1916782

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HOPX - HOP homeobox Gene

关于 HOPX

功能概要

HOPX 基因产物(5)

HOPX 蛋白结构

HOPX 蛋白互作信息

关联疾病

直系同源

热门区域

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HOPX - HOP homeobox Gene

关于 HOPX

功能概要

HOPX 基因产物(5)

HOPX 蛋白结构

HOPX 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z