2. Gene
  3. Hdac7 - histone deacetylase 7 Gene

Hdac7 - histone deacetylase 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：组蛋白脱乙酰酶 7

种属: Rattus norvegicus

同用名: Hdac7a

基因 ID: 84582 | 基因类型: protein coding

关于 Hdac7

Primary_assembly 7: 128,923,920-128,962,072 reverse strand.mRatBN7.2:CM026980.1

This gene has 6 transcripts (splice variants), 263 orthologues, 12 paralogues and is associated with 3 phenotypes. Biased expression in Thymus (RPKM 193.5), Lung (RPKM 114.3) and 8 other tissues.

功能概要

预计该基因编码的蛋白可实现多种功能，包括 14-3-3 蛋白结合活性；蛋白激酶 C 结合活性；和转录辅阻遏物活性。涉及多个过程，包括细胞对机械刺激的反应；神经元死亡的负调节；和神经元凋亡过程。预测位于胞质溶胶和细胞核中。预计是组蛋白脱乙酰酶复合物的一部分。与人类 HDAC7（组蛋白脱乙酰酶 7）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including 14-3-3 protein binding activity; protein kinase C binding activity; and transcription corepressor activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of neuron death; and neuron apoptotic process. Predicted to be located in cytosol and nucleus. Predicted to be part of histone deacetylase complex. Orthologous to human HDAC7 (histone deacetylase 7). [provided by Alliance of Genome Resources, Apr 2022]

Hdac7 基因产物(7)

mRNA Protein Name
XM_006242365.4 XP_006242427.2 histone deacetylase 7 isoform X2
XM_006242364.4 XP_006242426.2 histone deacetylase 7 isoform X1
XM_039080354.1 XP_038936282.1 histone deacetylase 7 isoform X1
XM_039080355.1 XP_038936283.1 histone deacetylase 7 isoform X6
XM_006242367.4 XP_006242429.2 histone deacetylase 7 isoform X5
XM_008765843.3 XP_008764065.1 histone deacetylase 7 isoform X4
XM_006242366.4 XP_006242428.2 histone deacetylase 7 isoform X3
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
19261284 RGD
involved in neuron apoptotic process IEP
IEP: 通过表达模式推断
21118817 RGD
involved in neuron differentiation IEP
IEP: 通过表达模式推断
12850547 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Hdac7 蛋白结构

PHA03247

PHA03247: cl33720 (121 - 542)

Arginase_HDAC

Arginase_HDAC: cl17011 (543 - 918)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 975 a.a.
蛋白主名 其他名称

histone deacetylase 7

HD7

HD7a

histone deacetylase 7A

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10221 Vorinostat Inhibitor 99.95% 是
HY-13322 Pracinostat Inhibitor 99.82% 是
Clinical Phase
生物活性分子 (9)
目录号 产品名 作用方式
纯度 Phase
HY-14842 Givinostat Inhibitor 98.16% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-10223 CUDC-101 Inhibitor 98.84% Phase 1
HY-15994 Citarinostat Inhibitor 99.30% Phase 1
Pre-clinical Phase
生物活性分子 (27)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18361 TMP195 Inhibitor 99.57% 否
HY-13428 Tubacin Inhibitor 99.54% 否
HY-18360 TMP269 Inhibitor 98.05% 否
HY-N6735 Apicidin Inhibitor 99.87% 否
HY-16699 Nexturastat A Inhibitor 98.28% 否
HY-115475 SW-100 Inhibitor 99.59% 否
HY-119939 CHDI-390576 Inhibitor 98.07% 否
HY-126330 SS-208 Inhibitor 99.00% 否
HY-149285 NT160 Inhibitor 99.58% 否
HY-117554 BRD9757 Inhibitor 99.75% 否
HY-146678 HDAC6-IN-5 Inhibitor / 否
HY-146679 HDAC6-IN-6 Inhibitor / 否
HY-150109 Purinostat mesylate Inhibitor / 否
HY-161778 ZG-126 Inhibitor / 否
HY-152226 MC2590 Inhibitor / 否
HY-150595 HDAC6-IN-10 Inhibitor / 否
HY-162630 HDAC6-IN-44 Inhibitor / 否
HY-15144B (S)-Trichostatin A Inhibitor / 否
HY-162319 Tubulin/HDAC-IN-4 Inhibitor / 否
HY-159172 HDAC3-IN-4 Inhibitor / 否
HY-150774 HDAC6/HSP90-IN-2 Inhibitor / 否
HY-149208 HDAC-IN-53 Inhibitor / 否
HY-152225 MC2625 Inhibitor / 否
HY-157740 XSJ-10 Inhibitor / 否
HY-149283 JAK/HDAC-IN-2 Inhibitor / 否
HY-146684 HDAC-IN-36 Inhibitor / 否
HY-163803 CM-444 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hdac7 NCBI NCBI:51564
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