2. Gene
  3. CDC42BPA - CDC42 binding protein kinase alpha Gene

CDC42BPA - CDC42 binding protein kinase alpha Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CDC42 结合蛋白激酶α

种属: Homo sapiens

同用名: MRCK; MRCKA; PK428

基因 ID: 8476 | 基因类型: protein coding

关于 CDC42BPA

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:226,989,858-227,318,492 (from NCBI)

This gene has 15 transcripts (splice variants), 234 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 11.8), kidney (RPKM 9.4) and 25 other tissues.

功能概要

该基因编码的蛋白质是丝氨酸/苏氨酸蛋白激酶家族的成员。该激酶包含多个功能域。其激酶结构域与强直性肌营养不良蛋白激酶 (DMPK) 高度相似。该激酶还包含一个 Rac 交互结合 (CRIB) 结构域，并已显示可结合 CDC42。它可能充当 CDC42 下游效应子，介导 CDC42 诱导的外周肌动蛋白形成，并促进细胞骨架重组。已经描述了多个选择性剪接的转录本变体。[RefSeq 提供，2018 年 9 月]

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018]

CDC42BPA 基因产物(7)

mRNA Protein Name
NM_001366010.2 NP_001352939.1 serine/threonine-protein kinase MRCK alpha isoform D
NM_001366011.1 NP_001352940.1 serine/threonine-protein kinase MRCK alpha isoform E
NM_001366019.2 NP_001352948.1 serine/threonine-protein kinase MRCK alpha isoform C
NM_001387550.1 NP_001374479.1 serine/threonine-protein kinase MRCK alpha isoform F
NM_001394014.1 NP_001380943.1 serine/threonine-protein kinase MRCK alpha isoform G
NM_003607.4 NP_003598.2 serine/threonine-protein kinase MRCK alpha isoform B
NM_014826.5 NP_055641.3 serine/threonine-protein kinase MRCK alpha isoform A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
9092543 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
11283256 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
9092543 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9418861 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
9092543 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin cytoskeleton organization IDA
IDA: 通过直接分析推断
9418861 GOA
involved in actomyosin structure organization IMP
IMP: 通过突变表型推断
18854160 GOA
involved in cell migration IMP
IMP: 通过突变表型推断
18854160 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
9092543 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in actomyosin IDA
IDA: 通过直接分析推断
18854160 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDC42BPA 蛋白结构

Pkinase

Pkinase: Protein kinase domain (77 - 343)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (361 - 406)

DMPK_coil

DMPK_coil: DMPK coiled coil domain like (881 - 941)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (1000 - 1050)

CNH

CNH: CNH domain (1220 - 1482)

  • 0
  • 300
  • 600
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  • 1200
  • 1500
  • 1781 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase MRCK alpha

CDC42 binding protein kinase alpha (DMPK-like)

CDC42BPA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CDC42BPA Q5VT25 CDC42BPA Homo sapiens Q5VT25
Y2H Fragment Pooling
23414517
种属内
CDC42BPA Q5VT25 CDC42BPA Homo sapiens Q5VT25
Anti Tag CoIP
11283256
种属内
CDC42BPA Q5VT25 CDC42BPA Homo sapiens Q5VT25
Protein Kinase Assay
11283256
种属内
CDC42BPA Q5VT25 CDC42 Homo sapiens P60953
Y2H Pooling
20936779
种属内
CDC42BPA Q5VT25 CDC42 Homo sapiens P60953
IF
9418861
种属内
CDC42BPA Q5VT25 CDC42BPA Homo sapiens Q5VT25
Crosslink
11283256
种属内
CDC42BPA Q5VT25 CDC42 Homo sapiens P60953
Lambda Phage
9418861
种属内
CDC42BPA Q5VT25 CDC42 Homo sapiens P60953
Far-WB
9418861
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Myotonic Dystrophy 1

Myotonic Dystrophy

Dystrophia Myotonica

Steinert Disease

Myotonic Dystrophy Type 1

Myotonia Atrophica

DM1

Congenital Myotonic Dystrophy

Myotonia Dystrophica

Steinert Myotonic Dystrophy

Dystrophia Myotonica 1

Dm

Steinert'S Disease

Steinert Myotonic Dystrophy Syndrome

Myotonic Dystrophy Of Steinert

Dystrophia Myotonica Type 1

Myotonic Dystrophy Congenital

Dystrophy, Myotonic, Type 1

Dm - [Dystrophia Myotonica]

Myotonic Muscular Dystrophy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02301 CDC42BPA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CDC42BPA VGNC VGNC:60657
Macaca mulatta CDC42BPA VGNC VGNC:70799
Rattus norvegicus CDC42BPA RGD RGD:621406
Canis familiaris CDC42BPA VGNC VGNC:38997
Mus musculus CDC42BPA MGD MGI:2441841
Bos taurus CDC42BPA VGNC VGNC:27069
Others CDC42BPA NCBI
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