2. Gene
  3. LINGO1 - leucine rich repeat and Ig domain containing 1 Gene

LINGO1 - leucine rich repeat and Ig domain containing 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含富亮氨酸的重复序列和 Ig 结构域 1

种属: Homo sapiens

同用名: LERN1; MRT64; LRRN6A; UNQ201

基因 ID: 84894 | 基因类型: protein coding

关于 LINGO1

Cytogenetic location: 15q24.3 Genomic coordinates (GRCh38): 15:77,613,027-77,820,900 (from NCBI)

This gene has 14 transcripts (splice variants), 261 orthologues, 25 paralogues and is associated with 3 phenotypes. Biased expression in brain (RPKM 24.2), placenta (RPKM 1.9) and 3 other tissues.

功能概要

预测可启用表皮生长因子受体结合活性。预测作用于神经元和蛋白激酶 B 信号传导的上游或生成之内。预测位于质膜中。预计在细胞外基质和细胞外空间中具有活性。与常染色体隐性非综合征性智力障碍和青光眼有关。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable epidermal growth factor receptor binding activity. Predicted to act upstream of or within generation of neurons and protein kinase B signaling. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Implicated in autosomal recessive non-syndromic intellectual disability and glaucoma. [provided by Alliance of Genome Resources, Apr 2022]

LINGO1 基因产物(12)

mRNA Protein Name
NM_001301186.2 NP_001288115.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301187.2 NP_001288116.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301189.2 NP_001288118.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301191.2 NP_001288120.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301192.2 NP_001288121.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301194.2 NP_001288123.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301195.2 NP_001288124.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301197.2 NP_001288126.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301198.2 NP_001288127.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301199.2 NP_001288128.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301200.2 NP_001288129.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_032808.7 NP_116197.4 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform a precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14966521 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LINGO1 蛋白结构

LRR_8

LRR_8: Leucine rich repeat (120 - 179)

LRR_1

LRR_1: Leucine Rich Repeat (192 - 214)

LRR_1

LRR_1: Leucine Rich Repeat (289 - 308)

LRR_8

LRR_8: Leucine rich repeat (312 - 371)

I-set

I-set: Immunoglobulin I-set domain (429 - 514)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 620 a.a.
蛋白主名 其他名称

leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

leucine rich repeat neuronal 6A

LINGO1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LINGO1 Q96FE5 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
32296183
Intra LINGO1 Q96FE5 NTM Homo sapiens Q9P121-3
Validated Y2H
32296183
Intra LINGO1 Q96FE5 NGFR Homo sapiens P08138
Anti Tag CoIP
20659559
Intra LINGO1 Q96FE5 MACO1 Homo sapiens Q8N5G2
Y2H Array
32296183
Intra LINGO1 Q96FE5 EGFR Homo sapiens P00533
Anti Bait CoIP
17726113
Intra LINGO1 Q96FE5 APP Homo sapiens P05067-4
Anti Bait CoIP
22133804
Intra LINGO1 Q96FE5 APP Homo sapiens P05067-4
Anti Tag CoIP
22133804
Intra LINGO1 Q96FE5 HSD3B7 Homo sapiens Q9H2F3
Validated Y2H
32296183
Intra LINGO1 Q96FE5 SPAG5 Homo sapiens Q96R06
Y2H Prey Pooling
25416956
Intra LINGO1 Q96FE5 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra LINGO1 Q96FE5 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra LINGO1 Q96FE5 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra LINGO1 Q96FE5 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra LINGO1 Q96FE5 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Cross LINGO1 Q96FE5 Rtn4r Rattus norvegicus Q99M75
ELISA
14966521
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Intellectual Developmental Disorder, Autosomal Recessive 64

MRT64

Mental Retardation, Autosomal Recessive 64

Autosomal Recessive Intellectual Developmental Disorder 64

Mental Retardation, Autosomal Recessive, Type 64
Essential Tremor

Benign Essential Tremor

Familial Tremor

Hereditary Essential Tremor

Essential Hereditary Tremor

Shaky Hand Syndrome

Benign Essential Tremor Syndrome

Tremor Hereditary Essential

Essential Tremor, Susceptibility To

Tremor, Hereditary Essential
Tremor, Hereditary Essential, 1

ETM1

Fet1

Essential Tremor 1

Tremor, Familial Essential, 1

Essential Tremor, Hereditary, 1

Hereditary Essential Tremor 1

Tremor Hereditary Essential, 1

Tremor Familial Essential, 1

Tremor, Hereditary Essential 1

Tremor, Essential Hereditary, Type 1
Syndromic Intellectual Disability
Developmental And Epileptic Encephalopathy 24

DEE24

Epileptic Encephalopathy, Early Infantile, 24

Eiee24

Developmental And Epileptic Encephalopathy, 24

Early Infantile Epileptic Encephalopathy 24

Encephalopathy, Epileptic, Early Infantile, Type 24
Leber Optic Atrophy And Dystonia

LDYT

Marsden Syndrome

Leber Hereditary Optic Neuropathy With Dystonia

Leber Hereditary Optic Neuropathy And Dystonia

Familial Dystonia With Visual Failure And Striatal Lucencies

Dystonia, Familial, With Visual Failure And Striatal Lucencies

Leber Optic Atrophy With Dystonia

Dystonia Familial, With Visual Failure And Striatal Lucencies

Lhon And Dystonia

Leber'S Hereditary Optic Neuropathy With Dystonia
Primary Progressive Multiple Sclerosis

Ppms

Primary-Progressive Ms

Multiple Sclerosis, Primary Progressive
Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid
Pelizaeus-Merzbacher Disease

PMD

HLD1

Pelizaeus-Merzbacher Brain Sclerosis

Leukodystrophy, Hypomyelinating, 1

Diffuse Familial Brain Sclerosis

Pelizaeus Merzbacher Brain Sclerosis

Sudanophilic Leukodystrophy, Paelizeus-Merzbacher Type

Cockayne-Pelizaeus-Merzbacher Disease

Hypomyelinating Leukodystrophy 1

Leukodystrophy, Sudanophilic

Pelizaeus Merzbacher Disease

Hypomyelinating Leukodystrophy, 1

Sudanophilic Leukodystrophy

Pelizaeus-Merzbacher Disease, Connatal Form

Connatal Pmd

Pelizaeus-Merzbacher Disease Type Ii

Severe Pmd

Null Syndrome

Plp1 Null Syndrome

Pelizaeus-Merzbacher Disease, Null Syndrome

Brain Sclerosis Diffuse Familial

Sudanophilic Leukodystrophy Paelizeus-Merzbacher Type

Leukodystrophy Hypomyelinating 1

Diffuse Cerebral Sclerosis Of Schilder
Optic Nerve Disease

Optic Neuropathy

Disorder Of The Second Nerve

Optic Nerve Disorder

Optic Nerve

Abnormality Of The Optic Nerve

Optic Nerve Disorders

Neuropathy, Optic

Disorder Of The Optic Nerve
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Hypomyelinating Leukodystrophy

Hld

Leukodystrophy, Hypomyelinating
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07680 LINGO1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta LINGO1 VGNC VGNC:74094
Bos taurus LINGO1 VGNC VGNC:30899
Canis familiaris LINGO1 VGNC VGNC:42688
Felis catus LINGO1 VGNC VGNC:63236
Mus musculus LINGO1 MGD MGI:1915522
Rattus norvegicus LINGO1 RGD RGD:1308668
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