1. Gene
  2. GCM1 - glial cells missing transcription factor 1 Gene

GCM1 - glial cells missing transcription factor 1 Gene

中文名称:神经胶质细胞缺失转录因子 1

种属: Homo sapiens

同用名: GCMA; hGCMa

基因 ID: 8521 | 基因类型: protein coding

关于 GCM1

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:53,126,961-53,148,841 (from NCBI)

This gene has 1 transcript (splice variant), 130 orthologues and 1 paralogue. Biased expression in placenta (RPKM 5.9), testis (RPKM 0.6) and 1 other tissue.

功能概要

该基因编码具有 gcm 基序 (神经胶质细胞缺失基序) 的 DNA 结合蛋白。编码的蛋白质是果蝇神经胶质细胞缺失基因 (gcm) 的同系物。这种蛋白质与 GCM 基序 (A/G) CCCGCAT 结合,这是 DNA 结合蛋白已知靶标中的一个新序列。 N 端 DNA 结合域赋予该蛋白质独特的 DNA 结合活性。[RefSeq 提供,2008 年 7 月]

This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008]

GCM1 基因产物(1)

mRNA Protein Name
NM_003643.4 NP_003634.2 chorion-specific transcription factor GCMa
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
23867755 GOA
part of transcription regulator complex IDA
IDA: 通过直接分析推断
15385555 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GCM1 蛋白结构

GCM

GCM: GCM motif protein (29 - 169)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 436 a.a.
蛋白主名 其他名称

chorion-specific transcription factor GCMa

GCM motif protein 1

GCM1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GCM1 Q9NP62 DLX3 Homo sapiens O60479 28515447
种属内
GCM1 Q9NP62 GATA3 Homo sapiens P23771 26899996
种属内
GCM1 Q9NP62 GATA3 Homo sapiens P23771 26899996
种属内
GCM1 Q9NP62 FBXW2 Homo sapiens Q9UKT8 23651062
种属内
GCM1 Q9NP62 FBXW2 Homo sapiens Q9UKT8 23651062
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cardiomyopathy, Familial Restrictive, 2

RCM2

Restrictive Cardiomyopathy 2

Familial Restrictive Cardiomyopathy 2

Cardiomyopathy, Restrictive, Familial, Type 2

Placental Choriocarcinoma

Choriocarcinoma Of The Placenta

Gestational Choriocarcinoma

Gestational Chorionepithelioma

Molar Pregnancy With Choriocarcinoma

Cardiomyopathy, Familial Restrictive, 1

RCM1

Restrictive Cardiomyopathy 1

Rcm

Familial Restrictive Cardiomyopathy 1

Cardiomyopathy, Familial Restrictive 1

Cardiomyopathy, Restrictive, Familial, Type 1

Rcm-1

Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia

Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos

Placenta Disease

Placenta Diseases

Placenta Disorder

Pregnancy Complications

Placenta Disorders

Persistent Fetal Circulation Syndrome

Persistent Fetal Circulation

Fetal Circulation

Persistent Pulmonary Hypertension Of The Newborn

Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins

Persistent Foetal Circulation

Persistent Foetal Circulation Syndrome

Pfc - [Persistent Fetal Circulation] Syndrome

Pphn - [Persistent Pulmonary Hypertension Of The Newborn]

Newborn Pulmonary Hypertension

Primary Pulmonary Hypertension Of Newborn

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus GCM1 MGD MGI:108045
Macaca mulatta GCM1 VGNC VGNC:72903
Rattus norvegicus GCM1 RGD RGD:61852
Bos taurus GCM1 VGNC VGNC:29291
Felis catus GCM1 VGNC VGNC:102428
Canis familiaris GCM1 VGNC VGNC:41149