2. Gene
  3. GAS7 - growth arrest specific 7 Gene

GAS7 - growth arrest specific 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：生长停滞特异性 7

种属: Homo sapiens

基因 ID: 8522 | 基因类型: protein coding

关于 GAS7

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:9,910,606-10,198,606 (from NCBI)

This gene has 19 transcripts (splice variants), 273 orthologues, 5 paralogues and is associated with 74 phenotypes. Broad expression in brain (RPKM 53.9), skin (RPKM 13.3) and 17 other tissues.

功能概要

生长停滞特异性 7 主要在终末分化的脑细胞和成熟的小脑浦肯野神经元中表达。 GAS7 在神经元发育中起推定的作用。已经描述了编码 N 末端不同的蛋白质的几种转录变体。[RefSeq 提供，2008 年 7 月]

Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008]

GAS7 基因产物(4)

mRNA Protein Name
NM_001130831.2 NP_001124303.1 growth arrest-specific protein 7 isoform d
NM_003644.3 NP_003635.2 growth arrest-specific protein 7 isoform a
NM_201432.2 NP_958836.1 growth arrest-specific protein 7 isoform b
NM_201433.2 NP_958839.1 growth arrest-specific protein 7 isoform c

GAS7 蛋白结构

SH3_9

SH3_9: Variant SH3 domain (9 - 58)

WW

WW: WW domain (79 - 108)

FCH

FCH: Fes/CIP4, and EFC/F-BAR homology domain (203 - 296)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 476 a.a.
蛋白主名 其他名称

growth arrest-specific protein 7

GAS7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GAS7 O60861 NTAQ1 Homo sapiens Q96HA8
Y2H Array
25416956
种属内
GAS7 O60861 NTAQ1 Homo sapiens Q96HA8
Y2H Array
31515488
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 GAS7 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70208 GAS7 Protein, Human (His) O60861-1 (M1-I412) ≥95%

关联疾病

疾病名称 别名
Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E

Primary Open Angle Glaucoma

POAG

Adult-Onset Primary Open Angle Glaucoma

Chronic Simple Glaucoma

GLC1E

Primary Open Angle Glaucoma 1e

Glaucoma, Open Angle, Primary
Glaucoma, Normal Tension

Low Tension Glaucoma

Glaucoma, Normal Tension, Susceptibility To

Normal Tension Glaucoma

Ntg

Glaucoma, Normal Pressure

NPG

Glaucoma, Normal Pressure, Susceptibility To

Poag/Npg - [Normal Pressure Primary Open-Angle Glaucoma]
Primary Angle-Closure Glaucoma

Primary Angle Closure Glaucoma

Angle Closure Glaucoma

Acg - [Angle Closure Glaucoma]

Angle-Closure Glaucoma

Closed Angle Glaucoma

Acute Glaucoma

Prodromal Angle Closure Glaucoma
Open-Angle Glaucoma

Glaucoma Simplex

Pigmentary Glaucoma

Wide-Angle Glaucoma

Glaucoma, Open-Angle

Open Angle Glaucoma

Glaucoma Open-Angle

Chronic Simple Glaucoma

Coag - [Chronic Open-Angle Glaucoma]

Csg - [Chronic Simple Glaucoma]

Poag - [Primary Open-Angle Glaucoma]

Oag - [Open-Angle Glaucoma]

Chronic Glaucoma

Chronic Open Angle Glaucoma

Simple Glaucoma

Chronic Noncongestive Glaucoma

Ltg - [Low Tension Glaucoma]

Noncongestive Glaucoma

Nonobstructive Glaucoma

Normal Pressure Glaucoma

Primary Low Tension Glaucoma

Low-Tension Glaucoma

Residual Stage Low Tension Glaucoma

Open Cleft Glaucoma
Phacogenic Glaucoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05286 GAS7 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-164456 AMI-408 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta GAS7 VGNC VGNC:72886
Mus musculus GAS7 MGD MGI:1202388
Felis catus GAS7 VGNC VGNC:62470
Bos taurus GAS7 VGNC VGNC:29262
Canis familiaris GAS7 VGNC VGNC:41119
Rattus norvegicus GAS7 RGD RGD:621550
Others GAS7 NCBI
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