TRIM5 - tripartite motif containing 5 Gene

中文名称：含三方基序 5

种属: Homo sapiens

同用名: RNF88; TRIM5alpha

基因 ID: 85363 | 基因类型: protein coding

关于 TRIM5

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:5,588,635-5,685,074 (from NCBI)

This gene has 14 transcripts (splice variants), 173 orthologues and 80 paralogues. Ubiquitous expression in urinary bladder (RPKM 5.4), endometrium (RPKM 5.4) and 25 other tissues.

功能概要

由该基因编码的蛋白质是三联基序 (TRIM) 家族的成员。 TRIM 基序包括三个锌结合域、一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2，以及一个卷曲螺旋区域。该蛋白质通过卷曲螺旋区域形成同源寡聚体并定位于细胞质体。它似乎作为 E3 泛素连接酶发挥作用并泛素化自身以调节其亚细胞定位。它可能在逆转录病毒限制中起作用。已针对该基因描述了编码不同亚型的多个可变剪接转录物变体。[RefSeq 提供，2009 年 12 月]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]

TRIM5 基因产物(8)

mRNA	Protein	Name
NM_001410958.1	NP_001397887.1	tripartite motif-containing protein 5 isoform 4
NM_033034.3	NP_149023.2	tripartite motif-containing protein 5 isoform alpha
NM_033092.4	NP_149083.2	tripartite motif-containing protein 5 isoform gamma
NM_033093.4	NP_149084.2	tripartite motif-containing protein 5 isoform delta
NM_001410958.1	NP_001397887.1	tripartite motif-containing protein 5 isoform 4
NM_033034.3	NP_149023.2	tripartite motif-containing protein 5 isoform alpha
NM_033092.4	NP_149083.2	tripartite motif-containing protein 5 isoform gamma
NM_033093.4	NP_149084.2	tripartite motif-containing protein 5 isoform delta

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	17156811	GOA
enables pattern recognition receptor activity	IDA IDA: 通过直接分析推断	21512573	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12878161	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	11331580	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	25127057	GOA
enables protein-macromolecule adaptor activity	IPI IPI: 通过物理相互作用推断	25127057	GOA
enables transcription coactivator activity	IDA IDA: 通过直接分析推断	23077300	GOA
enables ubiquitin-protein transferase activity	IDA IDA: 通过直接分析推断	21512573	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in activation of innate immune response	IDA IDA: 通过直接分析推断	21512573	GOA
involved in autophagy	IDA IDA: 通过直接分析推断	25127057	GOA
involved in innate immune response	IDA IDA: 通过直接分析推断	18248090	GOA
involved in negative regulation of viral entry into host cell	IDA IDA: 通过直接分析推断	18248090	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	23077300	GOA
involved in positive regulation of MAPK cascade	IMP IMP: 通过突变表型推断	21512573	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: 通过突变表型推断	21512573	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: 通过直接分析推断	23077300	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: 通过突变表型推断	21512573	GOA
involved in protein K63-linked ubiquitination	IDA IDA: 通过直接分析推断	21512573	GOA
involved in regulation of lipopolysaccharide-mediated signaling pathway	IMP IMP: 通过突变表型推断	21512573	GOA
involved in regulation of protein localization	IMP IMP: 通过突变表型推断	25127057	GOA
involved in suppression of viral release by host	IDA IDA: 通过直接分析推断	18248090	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in P-body	IDA IDA: 通过直接分析推断	12878161	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	11331580	GOA
colocalizes with omegasome	IDA IDA: 通过直接分析推断	25127057	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRIM5 蛋白结构

zf-C3HC4_4

zf-B_box

SPRY

0
100
200
300
400
493 a.a.

蛋白主名

其他名称

tripartite motif-containing protein 5

RING-type E3 ubiquitin transferase TRIM5

TRIM5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TRIM5	Q9C035	SNAI1	Homo sapiens	O95863	Anti Tag CoIP	25203322
种属内	TRIM5	Q9C035	TRIM32	Homo sapiens	Q13049	Y2H Array	22493164
种属内	TRIM5	Q9C035	TRIM32	Homo sapiens	Q13049	Anti Tag CoIP	22493164
种属内	TRIM5	Q9C035	UBE2N	Homo sapiens	P61088	Y2H Array	19549727
种属内	TRIM5	Q9C035	TRIM5	Homo sapiens	Q9C035	Anti Tag CoIP	22493164
种属内	TRIM5	Q9C035	TRIM5	Homo sapiens	Q9C035	Y2H	22829933
种属内	TRIM5	Q9C035	UBE2D1	Homo sapiens	P51668	Y2H Array	19549727
种属内	TRIM5	Q9C035	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Array	19549727
种属内	TRIM5	Q9C035	TRIM34	Homo sapiens	Q9BYJ4	Y2H Array	22493164
种属内	TRIM5	Q9C035	MNAT1	Homo sapiens	P51948	Y2H Array	22493164
种属内	TRIM5	Q9C035	TRIM5	Homo sapiens	Q9C035	Y2H Array	22493164

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TRIM5 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71385	TRIM5 Protein, Human (His)	Q9C035-1 (M1-Q248)	≥95%
HY-P71637	TRIM5 Protein, Human (His, B2M)	Q9C035-1 (M1-S493)	≥95%
HY-P71385A	TRIM5 Protein, Human (N-His)	Q9C035-1 (M1-Q248)	≥95%

关联疾病

疾病名称

别名

Rubella

German Measles	Three Day Measles
Rubella Nos

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Mulibrey Nanism

MUL	Muscle-Liver-Brain-Eye Nanism
Pericardial Constriction And Growth Failure	Perheentupa Syndrome
Mulibrey Growth Disorder	Mulibrey Nanism Syndrome
Pericardial Constriction With Growth Failure	Nanism Mulibrey

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15053	TRIM5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	TRIM5	RGD	RGD:1304579
Mus musculus	TRIM5	MGD	MGI:3646853
Macaca mulatta	TRIM5	VGNC	VGNC:106441
Others	TRIM5	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TRIM5 - tripartite motif containing 5 Gene

关于 TRIM5

功能概要

TRIM5 基因产物(8)

TRIM5 蛋白结构

TRIM5 蛋白互作信息

重组 TRIM5 蛋白

关联疾病

直系同源

热门区域

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TRIM5 - tripartite motif containing 5 Gene

关于 TRIM5

功能概要

TRIM5 基因产物(8)

TRIM5 蛋白结构

TRIM5 蛋白互作信息

重组 TRIM5 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z