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  2. RGS8 - regulator of G protein signaling 8 Gene

RGS8 - regulator of G protein signaling 8 Gene

中文名称:G 蛋白信号调节器 8

种属: Homo sapiens

基因 ID: 85397 | 基因类型: protein coding

关于 RGS8

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:182,641,818-182,752,376 (from NCBI)

This gene has 7 transcripts (splice variants), 199 orthologues and 23 paralogues. Biased expression in thyroid (RPKM 1.7), brain (RPKM 1.0) and 3 other tissues.

功能概要

该基因是 G 蛋白信号转导 (RGS) 家族调节因子的成员,编码具有单个 RGS 结构域的蛋白质。 G 蛋白信号转导调节子 (RGS) 蛋白是 G 蛋白偶联受体复合物的调节和结构成分。它们加速通过 GTP 结合和水解循环转运至 GDP,从而终止信号转导,但矛盾的是,它们还加速受体刺激的激活。[RefSeq 提供,2008 年 7 月]

This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]

RGS8 基因产物(9)

mRNA Protein Name
NM_001387849.1 NP_001374778.1 regulator of G-protein signaling 8 isoform 2
NM_033345.4 NP_203131.1 regulator of G-protein signaling 8 isoform 1
NM_001387847.1 NP_001374776.1 regulator of G-protein signaling 8 isoform 2
NM_001369564.2 NP_001356493.1 regulator of G-protein signaling 8 isoform 2
XM_017002631.3 XP_016858120.1 regulator of G-protein signaling 8 isoform X1
NM_001102450.3 NP_001095920.1 regulator of G-protein signaling 8 isoform 2
XM_011510089.4 XP_011508391.1 regulator of G-protein signaling 8 isoform X1
XM_047432939.1 XP_047288895.1 regulator of G-protein signaling 8 isoform X2
NM_001387848.1 NP_001374777.1 regulator of G-protein signaling 8 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activator activity IDA
IDA: 通过直接分析推断
18434541 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of GTPase activity IDA
IDA: 通过直接分析推断
18434541 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RGS8 蛋白结构

RGS

RGS: Regulator of G protein signaling domain (56 - 171)

  • 0
  • 100
  • 180 a.a.
蛋白主名 其他名称

regulator of G-protein signaling 8

regulator of G-protein signalling 8

RGS8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RGS8 P57771 GOLGA2 Homo sapiens Q08379 25416956
种属内
RGS8 P57771 GOLGA2 Homo sapiens Q08379 25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spinocerebellar Ataxia 1

Spinocerebellar Ataxia Type 1

SCA1

Olivopontocerebellar Atrophy I

Opca1

Opca4

Menzel Type Opca

Schut-Haymaker Type Opca

Spinocerebellar Atrophy I

Opca I

Olivopontocerebellar Atrophy Iv

Opca Iv

Cerebelloparenchymal Disorder I

Cpd1

Olivopontocerebellar Atrophy 1

Cerebelloparenchymal Disorder 1

Olivopontocerebellar Atrophy 4

Spinocerebellar Atrophy 1

Type 1 Spinocerebellar Ataxia

Spinocerebellar Ataxia-1

Ataxia, Spinocerebellar, Type 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus RGS8 MGD MGI:108408
Canis familiaris RGS8 VGNC VGNC:45538
Rattus norvegicus RGS8 RGD RGD:3571
Felis catus RGS8 VGNC VGNC:107933
Bos taurus RGS8 VGNC VGNC:33925
Macaca mulatta RGS8 VGNC VGNC:100057