1. Gene
  2. MAPKAPK5 - MAPK activated protein kinase 5 Gene

MAPKAPK5 - MAPK activated protein kinase 5 Gene

中文名称:MAPK 活化蛋白激酶 5

种属: Homo sapiens

同用名: MK5; MK-5; NCFD; PRAK; MAPKAP-K5

基因 ID: 8550 | 基因类型: protein coding

关于 MAPKAPK5

Cytogenetic location: 12q24.12-q24.13 Genomic coordinates (GRCh38): 12:111,842,228-111,902,222 (from NCBI)

This gene has 10 transcripts (splice variants), 178 orthologues, 6 paralogues and is associated with 2 phenotypes. Ubiquitous expression in small intestine (RPKM 3.1), colon (RPKM 2.9) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种肿瘤抑制因子,是丝氨酸/苏氨酸激酶家族的成员。为了响应细胞应激和促炎细胞因子,该激酶通过 MAPK1/ERK、MAPK14/p38-alpha 和 MAPK11/p38-beta 等 MAP 激酶的磷酸化而被激活。编码的蛋白质存在于细胞核中,但在磷酸化和激活后易位至细胞质。这种激酶在其生理相关位点磷酸化热休克蛋白 HSP27。已经报道了编码不同亚型的该基因的两个交替剪接的转录物变体。[RefSeq 提供,2012 年 11 月]

The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]

MAPKAPK5 基因产物(11)

mRNA Protein Name
NM_001371479.1 NP_001358408.1 MAP kinase-activated protein kinase 5 isoform 3
NM_001371480.1 NP_001358409.1 MAP kinase-activated protein kinase 5 isoform 4
NM_001371481.1 NP_001358410.1 MAP kinase-activated protein kinase 5 isoform 5
NM_001371482.1 NP_001358411.1 MAP kinase-activated protein kinase 5 isoform 6
NM_001371483.1 NP_001358412.1 MAP kinase-activated protein kinase 5 isoform 7
NM_001371484.1 NP_001358413.1 MAP kinase-activated protein kinase 5 isoform 8
NM_001371485.1 NP_001358414.1 MAP kinase-activated protein kinase 5 isoform 9
NM_001371486.1 NP_001358415.1 MAP kinase-activated protein kinase 5 isoform 10
NM_001371487.1 NP_001358416.1 MAP kinase-activated protein kinase 5 isoform 11
NM_003668.4 NP_003659.2 MAP kinase-activated protein kinase 5 isoform 1
NM_139078.3 NP_620777.1 MAP kinase-activated protein kinase 5 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables p53 binding IDA
IDA: 通过直接分析推断
17254968 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17254968 GOA
enables protein serine/threonine kinase activity EXP
EXP: 通过实验结果推断
17254968 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
17254968 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Ras protein signal transduction IDA
IDA: 通过直接分析推断
17254968 GOA
acts upstream of positive regulation of telomere maintenance IMP
IMP: 通过突变表型推断
21531765 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
21531765 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
21329882 GOA
involved in regulation of translation IDA
IDA: 通过直接分析推断
21329882 GOA
involved in stress-induced premature senescence IDA
IDA: 通过直接分析推断
17254968 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MAPKAPK5 蛋白结构

Pkinase

Pkinase: Protein kinase domain (25 - 304)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 473 a.a.
蛋白主名 其他名称

MAP kinase-activated protein kinase 5

MAPKAP kinase 5

MAPKAPK5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MAPKAPK5 Q8IW41 MAPK6 Homo sapiens Q16659
Validated Y2H
25416956
种属内
MAPKAPK5 Q8IW41 MAPK6 Homo sapiens Q16659
Anti Tag CoIP
33961781
种属内
MAPKAPK5 Q8IW41 MAPK6 Homo sapiens Q16659
Pull Down
32707033
种属内
MAPKAPK5 Q8IW41 MAPK6 Homo sapiens Q16659
Y2H
21900206
种属内
MAPKAPK5 Q8IW41 MAPK6 Homo sapiens Q16659
Y2H Pooling
20936779
种属内
MAPKAPK5 Q8IW41 HSPB1 Homo sapiens P04792
Protein Kinase Assay
21575178
种属内
MAPKAPK5 Q8IW41 TP53 Homo sapiens P04637
Protein Kinase Assay
17254968
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 MAPKAPK5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74621 PRAK/MAPKAPK5 Protein, Human (sf9, His-GST) Q8IW41-2/NP_003659.2 (M1-Q471) ≥95%

关联疾病

疾病名称 别名
Neurocardiofaciodigital Syndrome

NCFD

Dientamoebiasis

Intestinal Trichomoniasis

Glioblastoma Mesenchymal Subtype
Pulmonary Immaturity

Primary Atelectasis Of Newborn

Primary Atelectasis, In Perinatal Period

Primary Failure To Expand Terminal Respiratory Units

Immature Lungs

Primary Atelectasis

Pulmonary Immaturity Nos

Lung Lobe Hypoplasia, Associated With Short Gestation

Lung Nonexpansion

Premature Lungs

Pulmonary Hypoplasia Associated With Short Gestation

Failure Of Expansion Of Terminal Respiratory Units

Primary Atelectasis Of Fetus Or Newborn

Primary Atelectasis In Perinatal Period

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus MAPKAPK5 VGNC VGNC:31230
Rattus norvegicus MAPKAPK5 RGD RGD:1564113
Mus musculus MAPKAPK5 MGD MGI:1333110
Canis familiaris MAPKAPK5 VGNC VGNC:43008
Felis catus MAPKAPK5 VGNC VGNC:68177
Macaca mulatta MAPKAPK5 VGNC VGNC:74655
Others MAPKAPK5 NCBI