CDC14B - cell division cycle 14B Gene

中文名称：细胞分裂周期 14B

种属: Homo sapiens

同用名: CDC14B3; Cdc14B1; Cdc14B2; hCDC14B

关于 CDC14B

功能概要

由该基因编码的蛋白质是双重特异性蛋白酪氨酸磷酸酶家族的成员。该蛋白与酿酒酵母 Cdc14 高度相似，后者是一种蛋白酪氨酸磷酸酶，参与细胞有丝分裂的退出和 DNA 复制的启动，表明其在细胞周期控制中的作用。这种蛋白质已被证明与肿瘤抑制蛋白 p53 相互作用并使其去磷酸化，并且被认为可以调节 p53 的功能。该基因的可变剪接导致编码不同亚型的 3 个转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the dual specificity protein tyrosine Phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine Phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]