CDC14A - cell division cycle 14A Gene

中文名称：细胞分裂周期 14A

种属: Homo sapiens

同用名: cdc14; DFNB32; DFNB35; hCDC14; DFNB105

基因 ID: 8556 | 基因类型: protein coding

关于 CDC14A

Cytogenetic location: 1p21.2 Genomic coordinates (GRCh38): 1:100,345,001-100,520,277 (from NCBI)

This gene has 14 transcripts (splice variants), 263 orthologues, 8 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 5.6), bone marrow (RPKM 3.3) and 24 other tissues.

功能概要

由该基因编码的蛋白质是双重特异性蛋白酪氨酸磷酸酶家族的成员。它与酿酒酵母 Cdc14 高度相似，后者是一种蛋白酪氨酸磷酸酶，参与细胞有丝分裂的退出和 DNA 复制的启动，表明其在细胞周期控制中的作用。这种蛋白质已被证明与肿瘤抑制蛋白 p53 相互作用并使其去磷酸化，并且被认为可以调节 p53 的功能。该基因的可变剪接导致编码不同亚型的几种转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the dual specificity protein tyrosine Phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine Phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

CDC14A 基因产物(6)

mRNA	Protein	Name
NM_001319210.2	NP_001306139.1	dual specificity protein phosphatase CDC14A isoform 4
NM_001319211.2	NP_001306140.1	dual specificity protein phosphatase CDC14A isoform 5
NM_001319212.2	NP_001306141.1	dual specificity protein phosphatase CDC14A isoform 6
NM_003672.4	NP_003663.2	dual specificity protein phosphatase CDC14A isoform 1
NM_033312.3	NP_201569.1	dual specificity protein phosphatase CDC14A isoform 2
NM_033313.3	NP_201570.1	dual specificity protein phosphatase CDC14A isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16221885	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in sensory perception of sound	IMP IMP: 通过突变表型推断	29293958	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in centrosome	IDA IDA: 通过直接分析推断	21399614	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDC14A 蛋白结构

DSPn

DSPc

0
100
200
300
400
500
594 a.a.

蛋白主名

其他名称

dual specificity protein phosphatase CDC14A

CDC10 (cell division cycle 10, S. cerevisiae, homolog)

CDC14A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CDC14A	Q9UNH5	ATPAF2	Homo sapiens	Q8N5M1	Validated Y2H	32296183
种属内	CDC14A	Q9UNH5	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Deafness, Autosomal Recessive 32, With Or Without Immotile Sperm

DFNB32	Hearing Impairment Infertile Male Syndrome
Hiims	Deafness, Autosomal Recessive 105, Formerly
Dfnb105, Formerly	Deafness, Autosomal Recessive, 32, With Or Without Immotile Sperm
Deafness, Autosomal Recessive 105	Hearing Impairment And Infertile Male Syndrome

Autosomal Recessive Nonsyndromic Deafness 32

Deafness, Autosomal Recessive 32	Autosomal Recessive Deafness 105
Autosomal Recessive Deafness 32	Dfnb32
Hearing Impairment Infertile Male Syndrome	Hiims
Deafness, Autosomal Recessive, Type 32

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb	Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb

Ear Malformation

Cup Ear

Rare Genetic Deafness

Rare Genetic Hearing Loss

Spermatogenic Failure 21

SPGF21

Myopathy, Centronuclear, 2

Myopathy, Centronuclear, Autosomal Recessive	Autosomal Recessive Centronuclear Myopathy
CNM2	Centronuclear Myopathy 2
Ar-Cnm	Myotubular Myopathy, Autosomal Recessive
Autosomal Recessive Myotubular Myopathy	Centronuclear Myopathy Autosomal Recessive
Myopathy, Centronuclear, Type 2

Pulmonary Immaturity

Primary Atelectasis Of Newborn	Primary Atelectasis, In Perinatal Period
Primary Failure To Expand Terminal Respiratory Units	Immature Lungs
Primary Atelectasis	Pulmonary Immaturity Nos
Lung Lobe Hypoplasia, Associated With Short Gestation	Lung Nonexpansion
Premature Lungs	Pulmonary Hypoplasia Associated With Short Gestation
Failure Of Expansion Of Terminal Respiratory Units	Primary Atelectasis Of Fetus Or Newborn
Primary Atelectasis In Perinatal Period

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-161673	CDC14A/B-IN-1	Inhibitor	/	否
HY-RS02285	CDC14A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	CDC14A	VGNC	VGNC:27059
Rattus norvegicus	CDC14A	RGD	RGD:1304649
Felis catus	CDC14A	VGNC	VGNC:60647
Macaca mulatta	CDC14A	VGNC	VGNC:70791
Mus musculus	CDC14A	MGD	MGI:2442676
Canis familiaris	CDC14A	VGNC	VGNC:38986

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CDC14A - cell division cycle 14A Gene

关于 CDC14A

功能概要

CDC14A 基因产物(6)

CDC14A 蛋白结构

CDC14A 蛋白互作信息

关联疾病

直系同源

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CDC14A - cell division cycle 14A Gene

关于 CDC14A

功能概要

CDC14A 基因产物(6)

CDC14A 蛋白结构

CDC14A 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z