2. Gene
  3. CDC14A - cell division cycle 14A Gene

CDC14A - cell division cycle 14A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞分裂周期 14A

种属: Homo sapiens

同用名: cdc14; DFNB32; DFNB35; hCDC14; DFNB105

基因 ID: 8556 | 基因类型: protein coding

关于 CDC14A

Cytogenetic location: 1p21.2 Genomic coordinates (GRCh38): 1:100,345,001-100,520,277 (from NCBI)

This gene has 14 transcripts (splice variants), 263 orthologues, 8 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 5.6), bone marrow (RPKM 3.3) and 24 other tissues.

功能概要

由该基因编码的蛋白质是双重特异性蛋白酪氨酸磷酸酶家族的成员。它与酿酒酵母 Cdc14 高度相似，后者是一种蛋白酪氨酸磷酸酶，参与细胞有丝分裂的退出和 DNA 复制的启动，表明其在细胞周期控制中的作用。这种蛋白质已被证明与肿瘤抑制蛋白 p53 相互作用并使其去磷酸化，并且被认为可以调节 p53 的功能。该基因的可变剪接导致编码不同亚型的几种转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the dual specificity protein tyrosine Phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine Phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

CDC14A 基因产物(6)

mRNA Protein Name
NM_001319210.2 NP_001306139.1 dual specificity protein phosphatase CDC14A isoform 4
NM_001319211.2 NP_001306140.1 dual specificity protein phosphatase CDC14A isoform 5
NM_001319212.2 NP_001306141.1 dual specificity protein phosphatase CDC14A isoform 6
NM_003672.4 NP_003663.2 dual specificity protein phosphatase CDC14A isoform 1
NM_033312.3 NP_201569.1 dual specificity protein phosphatase CDC14A isoform 2
NM_033313.3 NP_201570.1 dual specificity protein phosphatase CDC14A isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16221885 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in sensory perception of sound IMP
IMP: 通过突变表型推断
29293958 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
21399614 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDC14A 蛋白结构

DSPn

DSPn: Dual specificity protein phosphatase, N-terminal half (12 - 152)

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (217 - 325)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 594 a.a.
蛋白主名 其他名称

dual specificity protein phosphatase CDC14A

CDC10 (cell division cycle 10, S. cerevisiae, homolog)

CDC14A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CDC14A Q9UNH5 ATPAF2 Homo sapiens Q8N5M1
Validated Y2H
32296183
Intra CDC14A Q9UNH5 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Deafness, Autosomal Recessive 32, With Or Without Immotile Sperm

DFNB32

Hearing Impairment Infertile Male Syndrome

Hiims

Deafness, Autosomal Recessive 105, Formerly

Dfnb105, Formerly

Deafness, Autosomal Recessive, 32, With Or Without Immotile Sperm

Deafness, Autosomal Recessive 105

Hearing Impairment And Infertile Male Syndrome
Autosomal Recessive Nonsyndromic Deafness 32

Deafness, Autosomal Recessive 32

Autosomal Recessive Deafness 105

Autosomal Recessive Deafness 32

Dfnb32

Hearing Impairment Infertile Male Syndrome

Hiims

Deafness, Autosomal Recessive, Type 32
Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Deafness

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency
Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb

Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb

Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb

Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb

Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb
Ear Malformation

Cup Ear
Rare Genetic Deafness

Rare Genetic Hearing Loss
Spermatogenic Failure 21

SPGF21
Myopathy, Centronuclear, 2

Myopathy, Centronuclear, Autosomal Recessive

Autosomal Recessive Centronuclear Myopathy

CNM2

Centronuclear Myopathy 2

Ar-Cnm

Myotubular Myopathy, Autosomal Recessive

Autosomal Recessive Myotubular Myopathy

Centronuclear Myopathy Autosomal Recessive

Myopathy, Centronuclear, Type 2
Pulmonary Immaturity

Primary Atelectasis Of Newborn

Primary Atelectasis, In Perinatal Period

Primary Failure To Expand Terminal Respiratory Units

Immature Lungs

Primary Atelectasis

Pulmonary Immaturity Nos

Lung Lobe Hypoplasia, Associated With Short Gestation

Lung Nonexpansion

Premature Lungs

Pulmonary Hypoplasia Associated With Short Gestation

Failure Of Expansion Of Terminal Respiratory Units

Primary Atelectasis Of Fetus Or Newborn

Primary Atelectasis In Perinatal Period
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-161673 CDC14A/B-IN-1 Inhibitor / 否
HY-RS02285 CDC14A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CDC14A VGNC VGNC:27059
Rattus norvegicus CDC14A RGD RGD:1304649
Felis catus CDC14A VGNC VGNC:60647
Macaca mulatta CDC14A VGNC VGNC:70791
Mus musculus CDC14A MGD MGI:2442676
Canis familiaris CDC14A VGNC VGNC:38986
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z