DENR - density regulated re-initiation and release factor Gene

中文名称：密度调节再引发和释放因子

种属: Homo sapiens

同用名: DRP; DRP1; SMAP-3

基因 ID: 8562 | 基因类型: protein coding

关于 DENR

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,752,824-122,771,064 (from NCBI)

This gene has 4 transcripts (splice variants) and 230 orthologues. Ubiquitous expression in thyroid (RPKM 16.4), lymph node (RPKM 16.3) and 25 other tissues.

功能概要

该基因编码一种蛋白质，其表达被发现在高密度培养细胞中增加，但在生长停滞期间不增加。该基因还显示在过表达 HER-2/neu 原癌基因的细胞中表达增加。该蛋白质包含一个 SUI1 结构域。在出芽酵母中，SUI1 是一种翻译起始因子，与 eIF-2 和起始子 tRNA-Met 一起，将核糖体引导至正确的翻译起始位点。在哺乳动物、昆虫和植物中发现了类似于 SUI 的蛋白质。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and Plants. [provided by RefSeq, Jul 2008]

DENR 基因产物(1)

mRNA	Protein	Name
NM_003677.5	NP_003668.2	density-regulated protein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16169070	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in IRES-dependent viral translational initiation	IDA IDA: 通过直接分析推断	20713520	GOA
involved in formation of translation preinitiation complex	IDA IDA: 通过直接分析推断	20713520	GOA
involved in ribosome disassembly	IDA IDA: 通过直接分析推断	20713520	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in cytoplasm	IDA IDA: 通过直接分析推断	16982740	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DENR 蛋白结构

SUI1

0
100
198 a.a.

蛋白主名

其他名称

density-regulated protein

smooth muscle cell associated protein-3

DENR 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DENR	O43583	MARCHF5	Homo sapiens	Q9NX47	Anti Tag CoIP	16874301
种属内	DENR	O43583	MARCHF5	Homo sapiens	Q9NX47	Anti Tag CoIP	16936636
种属内	DENR	O43583	NELFB	Homo sapiens	Q8WX92	TAP	20195357
种属内	DENR	O43583	MCTS1	Homo sapiens	Q9ULC4	Validated Y2H	32296183
种属内	DENR	O43583	MCTS1	Homo sapiens	Q9ULC4	Y2H	21516116
种属内	DENR	O43583	MCTS1	Homo sapiens	Q9ULC4	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 DENR 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72172	DENR Protein, Human (His-SUMO)	O43583 (A2-K198)	≥95%

关联疾病

疾病名称

别名

Capillary Malformations, Congenital

Familial Multiple Nevi Flammei	Nevi Flammei, Familial Multiple
CMC	Port-Wine Stain
Capillary Malformations	Cmal
Familial Multiple Port-Wine Stains	Capillary Malformation
Capillary Malformations, Congenital, 1, Somatic, Mosaic	Congenital Capillary Malformations
Port-Wine Stain Familial Multiple	Hereditary Capillary Malformations
Capillary Malformations, Hereditary	Capillary Malformations, Congenital, Type 1, Somatic, Mosaic
Strawberry Nevus Of Skin	Naevus Flammeus

Optic Nerve Disease

Optic Neuropathy	Disorder Of The Second Nerve
Optic Nerve Disorder	Optic Nerve
Abnormality Of The Optic Nerve	Optic Nerve Disorders
Neuropathy, Optic	Disorder Of The Optic Nerve

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03692	DENR Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	DENR	MGD	MGI:1915434
Canis familiaris	DENR	VGNC	VGNC:52927
Macaca mulatta	DENR	VGNC	VGNC:108337
Rattus norvegicus	DENR	RGD	RGD:1584200
Felis catus	DENR	VGNC	VGNC:80435
Others	DENR	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DENR - density regulated re-initiation and release factor Gene

关于 DENR

功能概要

DENR 基因产物(1)

DENR 蛋白结构

DENR 蛋白互作信息

重组 DENR 蛋白

关联疾病

直系同源

热门区域

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DENR - density regulated re-initiation and release factor Gene

关于 DENR

功能概要

DENR 基因产物(1)

DENR 蛋白结构

DENR 蛋白互作信息

重组 DENR 蛋白

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z