SNX3 - sorting nexin 3 Gene

中文名称：排序 nexin 3

种属: Homo sapiens

同用名: SDP3; Grd19; MCOPS8

基因 ID: 8724 | 基因类型: protein coding

关于 SNX3

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:108,211,222-108,261,040 (from NCBI)

This gene has 4 transcripts (splice variants), 222 orthologues, 15 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 95.7), adrenal (RPKM 90.6) and 25 other tissues.

功能概要

该基因编码分选连接蛋白家族的一个成员。该家族的成员包含一个 phox (PX) 结构域，它是一个磷酸肌醇结合结构域，并参与细胞内运输。与大多数家族成员一样，这种蛋白质不包含卷曲螺旋区域。这种蛋白质与 phosphatidylinositol-3-phosphate 相互作用，并参与蛋白质运输。该基因的假基因存在于性染色体上。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2014 年 7 月]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. A pseudogene of this gene is present on the sex chromosomes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

SNX3 基因产物(4)

mRNA	Protein	Name
NM_001300928.2	NP_001287857.1	sorting nexin-3 isoform c
NM_001300929.2	NP_001287858.1	sorting nexin-3 isoform d
NM_003795.6	NP_003786.1	sorting nexin-3 isoform a
NM_152827.4	NP_690040.1	sorting nexin-3 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables phosphatidylinositol-3-phosphate binding	IDA IDA: 通过直接分析推断	11433298	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17474147	GOA
enables protein phosphatase binding	IPI IPI: 通过物理相互作用推断	17622474	GOA
enables retromer complex binding	IDA IDA: 通过直接分析推断	30213940	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in intralumenal vesicle formation	IMP IMP: 通过突变表型推断	18767904	GOA
involved in membrane invagination	IDA IDA: 通过直接分析推断	18767904	GOA
involved in negative regulation of early endosome to late endosome transport	IDA IDA: 通过直接分析推断	18767904	GOA
involved in negative regulation of phagocytosis	IMP IMP: 通过突变表型推断	23237080	GOA
involved in negative regulation of protein catabolic process	IDA IDA: 通过直接分析推断	18767904	GOA
involved in negative regulation of protein transport	IDA IDA: 通过直接分析推断	18767904	GOA
involved in negative regulation of viral entry into host cell	IDA IDA: 通过直接分析推断	18767904	GOA
involved in protein to membrane docking	IDA IDA: 通过直接分析推断	24344282	GOA
involved in regulation of Wnt signaling pathway	IMP IMP: 通过突变表型推断	21725319	GOA
involved in response to bacterium	IDA IDA: 通过直接分析推断	20482551	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in clathrin-coated vesicle	IDA IDA: 通过直接分析推断	21725319	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	11279102	GOA
located in cytosol	IDA IDA: 通过直接分析推断	9819414	GOA
located in early endosome	IDA IDA: 通过直接分析推断	11433298	GOA
located in early endosome membrane	IDA IDA: 通过直接分析推断	18767904	GOA
located in early phagosome	IDA IDA: 通过直接分析推断	23237080	GOA
located in endosome membrane	IDA IDA: 通过直接分析推断	15673616	GOA
part of retromer complex	IDA IDA: 通过直接分析推断	21725319	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SNX3 蛋白结构

0
100
162 a.a.

蛋白主名

其他名称

sorting nexin-3

sorting nexin 3A

SNX3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SNX3	O60493	RPRM	Homo sapiens	Q9NS64	Y2H Prey Pooling	32296183
种属内	SNX3	O60493	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
种属内	SNX3	O60493	RPRM	Homo sapiens	Q9NS64	Y2H Array	32296183
种属内	SNX3	O60493	ARL6IP1	Homo sapiens	Q15041	Validated Y2H	25416956
种属内	SNX3	O60493	ARL6IP1	Homo sapiens	Q15041	Y2H Array	25416956
种属内	SNX3	O60493	CRK	Homo sapiens	P46108	Peptide Array	17474147

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Microphthalmia, Syndromic 8

MCOPS8	Mmep Syndrome
Mmep	Syndromic Microphthalmia Type 8
Viljoen-Smart Syndrome	Microcephaly, Microphthalmia, Ectrodactyly Of Lower Limbs, And Prognathism
Syndromic Microphthalmia 8	Microcephaly-Microphthalmia-Ectrodactyly Of Lower Limbs-Prognathism Syndrome
Microphthalmia Syndromic 8	Microcephaly Microphthalmia Ectrodactyly Of Lower Limbs And Prognathism
Viljoen Smart Syndrome	Microphthalmia, Syndromic, 8
Microcephaly, Microphthalmia, Ectrodactyly Of Lower Limbs And Prognathism

Syndromic Microphthalmia

Microphthalmia, Syndromic

Microphthalmia

Microphthalmos	Isolated Anophthalmia-Microphthalmia Syndrome
Isolated Microphthalmia-Anophthalmia-Coloboma	Simple Microphthalmos
Clinical Anophthalmia	Isolated Anophthalmia - Microphthalmia
Isolated Pure Microphthalmia	Mac Spectrum
Microphthalmia-Anophthalmia-Coloboma Spectrum	Primitive Anophthalmia
Globe Of Eye Small	Small Eyeball
Hypoplasia Of Eye	Isolated Nanophthalmos
Rudimentary Eye	Dysplasia Of Eye

Fraser Syndrome 2

FRASRS2

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13539	SNX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	SNX3	VGNC	VGNC:77683
Rattus norvegicus	SNX3	RGD	RGD:1595151
Canis familiaris	SNX3	VGNC	VGNC:46636
Bos taurus	SNX3	VGNC	VGNC:35107
Mus musculus	SNX3	MGD	MGI:1860188

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SNX3 - sorting nexin 3 Gene

关于 SNX3

功能概要

SNX3 基因产物(4)

SNX3 蛋白结构

SNX3 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

SNX3 - sorting nexin 3 Gene

关于 SNX3

功能概要

SNX3 基因产物(4)

SNX3 蛋白结构

SNX3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z