ADAM19 - ADAM metallopeptidase domain 19 Gene

中文名称：ADAM 金属肽酶结构域 19

种属: Homo sapiens

同用名: MLTNB; FKSG34; MADDAM

关于 ADAM19

功能概要

该基因编码 ADAM (一种去整合素和金属蛋白酶结构域) 家族的成员。该家族的成员是膜锚定蛋白，在结构上与蛇毒解离蛋白相关，并参与涉及细胞-细胞和细胞-基质相互作用的各种生物过程，包括受精、肌肉发育和神经发生。该成员是 I 型跨膜蛋白，可作为树突状细胞分化的标志物。它已被证明是一种活性金属蛋白酶，可能参与细胞迁移、细胞粘附、细胞-细胞和细胞-基质相互作用以及信号转导等正常生理过程。它被提议在病理过程中发挥作用，例如癌症、炎症性疾病、肾脏疾病和阿尔茨海默氏病。[RefSeq 提供，2013 年 5 月]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as Cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]