2. Gene
  3. EPS8L1 - EPS8 like 1 Gene

EPS8L1 - EPS8 like 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：EPS8 样 1

种属: Homo sapiens

同用名: DRC3; EPS8R1; PP10566

基因 ID: 54869 | 基因类型: protein coding

关于 EPS8L1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,075,869-55,087,923 (from NCBI)

This gene has 19 transcripts (splice variants), 259 orthologues and 3 paralogues. Biased expression in esophagus (RPKM 25.5), skin (RPKM 19.7) and 12 other tissues.

功能概要

该基因编码一种与表皮生长因子受体通路底物 8 (EPS8) 相关的蛋白质，EPS8 是表皮生长因子受体的底物。这种蛋白质的功能是未知的。已发现该基因至少有两种编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. At least two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

EPS8L1 基因产物(2)

mRNA Protein Name
NM_017729.4 NP_060199.3 epidermal growth factor receptor kinase substrate 8-like protein 1 isoform b
NM_133180.3 NP_573441.2 epidermal growth factor receptor kinase substrate 8-like protein 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables T cell receptor binding IPI
IPI: 通过物理相互作用推断
17617578 GOA
enables actin binding IDA
IDA: 通过直接分析推断
14565974 GOA
contributes to guanyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
14565974 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14565974 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Rho protein signal transduction IDA
IDA: 通过直接分析推断
14565974 GOA
involved in positive regulation of ruffle assembly IGI
IGI: 通过遗传相互作用推断
14565974 GOA
involved in regulation of Rho protein signal transduction IDA
IDA: 通过直接分析推断
14565974 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protein-containing complex IDA
IDA: 通过直接分析推断
14565974 GOA
located in ruffle membrane IDA
IDA: 通过直接分析推断
14565974 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EPS8L1 蛋白结构

PTB

PTB: Phosphotyrosine-binding domain (35 - 165)

SH3_1

SH3_1: SH3 domain (487 - 528)

  • 0
  • 200
  • 400
  • 600
  • 723 a.a.
蛋白主名 其他名称

epidermal growth factor receptor kinase substrate 8-like protein 1

EPS8-like protein 1

EPS8L1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra EPS8L1 Q8TE68 CD3E Homo sapiens P07766
Anti Tag CoIP
17617578
Intra EPS8L1 Q8TE68 CD3E Homo sapiens P07766
Filamentous Phage
17617578
Intra EPS8L1 Q8TE68 CD3E Homo sapiens P07766
ITC
18644376
Intra EPS8L1 Q8TE68 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra EPS8L1 Q8TE68 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Villous Adenocarcinoma
Fetal Akinesia Deformation Sequence 4

FADS4

Fetal Akinesia Deformation Sequence Syndrome 4

Akinesia, Fetal, Deformation Sequence, Type 4
Spinal Canal Intradural Extramedullary Neoplasm

Intradural Extramedullary Spinal Tumors

Intradural Extramedullary Spinal Canal Neoplasm
Fetal Akinesia Deformation Sequence 1

Fetal Akinesia Deformation Sequence

Fads

Fetal Akinesia Sequence

FADS1

Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia

Pena-Shokeir Syndrome Type 1

Fetal Akinesia Deformation Sequence Syndrome

Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome

Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia

Pena-Shokeir Syndrome, Type I

Foetal Akinesia Deformation Sequence Syndrome

Foetal Akinesia Sequence

Fetal Akinesia Deformation Sequence Syndrome 1

Pena-Shokeir Syndrome, Type 1

Pena Shokeir Syndrome, Type 1

Akinesia, Fetal, Deformation Sequence

Akinesia, Fetal, Deformation Sequence, Type 1

Pena-Shokeir Syndrome Type I
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04455 EPS8L1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus EPS8L1 VGNC VGNC:61921
Mus musculus EPS8L1 MGD MGI:1914675
Canis familiaris EPS8L1 VGNC VGNC:40428
Bos taurus EPS8L1 VGNC VGNC:28556
Rattus norvegicus EPS8L1 RGD RGD:1311146
Macaca mulatta EPS8L1 VGNC VGNC:109623
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