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  2. RNMT - RNA guanine-7 methyltransferase Gene

RNMT - RNA guanine-7 methyltransferase Gene

中文名称:RNA 鸟嘌呤 7 甲基转移酶

种属: Homo sapiens

同用名: MET; Met; CMT1; cm1p; hMet; CMT1c; hCMT1; RG7MT1; N7-MTase

基因 ID: 8731 | 基因类型: protein coding

关于 RNMT

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:13,726,673-13,764,556 (from NCBI)

This gene has 10 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in brain (RPKM 9.8), thyroid (RPKM 9.0) and 25 other tissues.

功能概要

启用 RNA 结合活性和 mRNA (鸟嘌呤-N7-) -甲基转移酶活性。参与 7-甲基鸟苷 mRNA 加帽。位于纤维中心和核质中。部分 mRNA 帽结合活性复合体; mRNA 帽甲基转移酶复合体;和受体复合体。 [由基因组资源联盟提供,2022 年 4 月]

Enables RNA binding activity and mRNA (guanine-N7-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping. Located in fibrillar center and nucleoplasm. Part of mRNA cap binding activity complex; mRNA cap methyltransferase complex; and receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

RNMT 基因产物(5)

mRNA Protein Name
NM_001308263.2 NP_001295192.1 mRNA cap guanine-N7 methyltransferase isoform 1
NM_001378132.1 NP_001365061.1 mRNA cap guanine-N7 methyltransferase isoform 3
NM_001378134.1 NP_001365063.1 mRNA cap guanine-N7 methyltransferase isoform 1
NM_001378135.1 NP_001365064.1 mRNA cap guanine-N7 methyltransferase isoform 2
NM_003799.3 NP_003790.1 mRNA cap guanine-N7 methyltransferase isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IMP
IMP: 通过突变表型推断
9790902 GOA
enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IDA
IDA: 通过直接分析推断
22099306 GOA
enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IMP
IMP: 通过突变表型推断
9790902 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22099306 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 7-methylguanosine mRNA capping IDA
IDA: 通过直接分析推断
27422871 GOA
involved in 7-methylguanosine mRNA capping IMP
IMP: 通过突变表型推断
9790902 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of mRNA cap methyltransferase RNMT:RAMAC complex IDA
IDA: 通过直接分析推断
22099306 GOA
part of mRNA capping enzyme complex IDA
IDA: 通过直接分析推断
27422871 GOA
located in nucleus IDA
IDA: 通过直接分析推断
9790902 GOA
part of receptor complex IDA
IDA: 通过直接分析推断
23382219 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RNMT 蛋白结构

Pox_MCEL

Pox_MCEL: mRNA capping enzyme (137 - 475)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 476 a.a.
蛋白主名 其他名称

mRNA cap guanine-N7 methyltransferase

RNA (guanine-7-) methyltransferase

RNMT 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RNMT O43148 PLEKHA3 Homo sapiens Q9HB20 32296183
种属内
RNMT O43148 PLEKHA3 Homo sapiens Q9HB20 32296183
种属内
RNMT O43148 PLEKHA3 Homo sapiens Q9HB20 32296183
种属内
RNMT O43148 GMCL1 Homo sapiens Q96IK5 32296183
种属内
RNMT O43148 GMCL1 Homo sapiens Q96IK5 32296183
种属内
RNMT O43148 GMCL1 Homo sapiens Q96IK5 32296183
种属内
RNMT O43148 KPNA2 Homo sapiens P52292 32296183
种属内
RNMT O43148 KPNA2 Homo sapiens P52292 32296183
种属内
RNMT O43148 KPNA2 Homo sapiens P52292 32296183
种属内
RNMT O43148 KPNA6 Homo sapiens O60684 33961781
种属内
RNMT O43148 KPNA6 Homo sapiens O60684 32296183
种属内
RNMT O43148 KPNA6 Homo sapiens O60684 32296183
种属内
RNMT O43148 KPNA6 Homo sapiens O60684 32296183
种属内
RNMT O43148 RAMAC Homo sapiens Q9BTL3 30021884
种属内
RNMT O43148 RAMAC Homo sapiens Q9BTL3 32296183
种属内
RNMT O43148 RAMAC Homo sapiens Q9BTL3 32296183
种属内
RNMT O43148 RAMAC Homo sapiens Q9BTL3 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Microphthalmia, Isolated 6

Isolated Microphthalmia 6

MCOP6

Microphthalmia, Posterior Nonsyndromic

Posterior Nonsyndromic Microphthalmia

Microphthalmia, Isolated, 6

Autosomal Recessive Posterior Microphthalmos

Posterior Non-Syndromic Microphthalmia

Microphthalmia, Isolated, Type 6

Cardiomyopathy, Familial Restrictive, 1

RCM1

Restrictive Cardiomyopathy 1

Rcm

Familial Restrictive Cardiomyopathy 1

Cardiomyopathy, Familial Restrictive 1

Cardiomyopathy, Restrictive, Familial, Type 1

Rcm-1

Dubowitz Syndrome

Dubowitz'S Syndrome

Dwarfism-Eczema-Peculiar Facies Syndrome

Intrauterine Growth Restriction, Short Stature, Microcephaly, Mild Intellectual Disability With Behavior Problems, Eczema, And Unusual And Distinctive Faci

Hypermethioninemia

Hepatic Methionine Adenosyltransferase Deficiency

Deficiency Of Methionine Adenosyltransferase

Glycine N-Methyltransferase Deficiency

Met

S-Adenosylhomocysteine Hydrolase Deficiency

Gnmt Deficiency

Mat Deficiency

Methionine Adenosyltransferase Deficiency

Methioninemia

Deficiency Of Acetyl-Coa Acetyltransferase

Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor

Williams-Beuren Syndrome

Williams Syndrome

WBS

Wms

Deletion 7q11.23

Monosomy 7q11.23

Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

Fanconi Schlesinger Syndrome

Beuren Syndrome

Elfin Facies Syndrome

Elfin Facies With Hypercalcemia

Hypercalcemia-Supravalvar Aortic Stenosis

Ws

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus RNMT MGD MGI:1915147
Bos taurus RNMT VGNC VGNC:34077
Felis catus RNMT VGNC VGNC:64710
Rattus norvegicus RNMT RGD RGD:1309242
Macaca mulatta RNMT VGNC VGNC:76710