RIOK3 - RIO kinase 3 Gene

中文名称：RIO 激酶 3

种属: Homo sapiens

同用名: SUDD

基因 ID: 8780 | 基因类型: protein coding

关于 RIOK3

Cytogenetic location: 18q11.2 Genomic coordinates (GRCh38): 18:23,453,287-23,483,140 (from NCBI)

This gene has 11 transcripts (splice variants), 211 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 81.4), esophagus (RPKM 38.1) and 24 other tissues.

功能概要

该基因首先通过其产物与构巢曲霉 SUDD 蛋白的相似性得到鉴定。该基因现在被认为是右开放阅读框 (RIO) 激酶基因家族的成员。该基因编码定位于细胞质的丝氨酸/苏氨酸激酶，并在前 40 S 核糖体亚基的加工中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2017 年 1 月]

This gene was first identified by the similarity of its product to the Aspergillus nidulans SUDD protein. This gene is now recognized as a member of the right open reading frame (RIO) kinase gene family. This gene encodes a serine/threonine kinase that localizes to the cytoplasm and plays a role in the processing of the pre-40 S ribosomal subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]

RIOK3 基因产物(2)

mRNA	Protein	Name
NM_001348193.2	NP_001335122.1	serine/threonine-protein kinase RIO3 isoform 2
NM_003831.5	NP_003822.2	serine/threonine-protein kinase RIO3 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables caspase binding	IDA IDA: 通过直接分析推断	19557502	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19557502	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	25865883	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to dsDNA	IMP IMP: 通过突变表型推断	24807708	GOA
involved in cellular response to dsRNA	IMP IMP: 通过突变表型推断	24807708	GOA
involved in cellular response to virus	IMP IMP: 通过突变表型推断	24807708	GOA
involved in maturation of SSU-rRNA	IMP IMP: 通过突变表型推断	22418843	GOA
involved in negative regulation of MDA-5 signaling pathway	IMP IMP: 通过突变表型推断	25865883	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: 通过直接分析推断	19557502	GOA
involved in negative regulation of protein-containing complex assembly	IDA IDA: 通过直接分析推断	25865883	GOA
involved in positive regulation of innate immune response	IMP IMP: 通过突变表型推断	24807708	GOA
involved in positive regulation of interferon-beta production	IMP IMP: 通过突变表型推断	24807708	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of preribosome, small subunit precursor	IDA IDA: 通过直接分析推断	22072790	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RIOK3 蛋白结构

RIO1

0
100
200
300
400
519 a.a.

蛋白主名

其他名称

serine/threonine-protein kinase RIO3

homolog of the Aspergillus nidulans sudD gene product

RIOK3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RIOK3	O14730	CASP10	Homo sapiens	Q92851-7	Pull Down	19557502
种属内	RIOK3	O14730	IRF3	Homo sapiens	Q14653	Anti Tag CoIP	24807708
种属内	RIOK3	O14730	IRF3	Homo sapiens	Q14653	Anti Bait CoIP	24807708
种属内	RIOK3	O14730	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	24807708
种属内	RIOK3	O14730	CASP10	Homo sapiens	Q92851	Y2H	19557502
种属内	RIOK3	O14730	CASP10	Homo sapiens	Q92851	Anti Tag CoIP	21988832
种属内	RIOK3	O14730	IFIH1	Homo sapiens	Q9BYX4	Y2H	25865883
种属内	RIOK3	O14730	IFIH1	Homo sapiens	Q9BYX4	Confocal	25865883
种属内	RIOK3	O14730	IFIH1	Homo sapiens	Q9BYX4	Anti Tag CoIP	25865883

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cecum Carcinoma

Cecum Cancer	Caecum Carcinoma
Carcinoma Of Cecum	Cecal Cancer
Malignant Neoplasm Of Caecum	Malignant Tumor Of The Cecum

Filippi Syndrome

Scott Craniodigital Syndrome With Mental Retardation	Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome
FLPIS	Scott Bryant Graham Syndrome
Craniodigital-Intellectual Disability Syndrome	Scott Craniodigital Syndrome
Scott-Bryant-Graham Syndrome	Syndactyly, Type I, With Microcephaly And Mental Retardation
Syndactyly Type I With Microcephaly And Intellectual Disability	Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly
Craniodigital Syndrome With Intellectual Disability	Craniodigital Syndrome-Intellectual Disability Syndrome
Craniodigital Syndrome-Intellectual Disability, Scott Type	Intellectual Disability-Craniodigital Syndrome

Cecum Adenocarcinoma

Cecal Adenocarcinoma

Adenocarcinoma Of Cecum

Diverticulitis Of Colon

Colonic Diverticular Disease	Diverticulitis, Colonic
Diverticular Disease Of Colon

Diverticulitis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11990	RIOK3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	RIOK3	VGNC	VGNC:53629
Mus musculus	RIOK3	MGD	MGI:1914128
Bos taurus	RIOK3	VGNC	VGNC:49977
Rattus norvegicus	RIOK3	RGD	RGD:1310833
Felis catus	RIOK3	VGNC	VGNC:64638
Macaca mulatta	RIOK3	VGNC	VGNC:104241
Others	RIOK3	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RIOK3 - RIO kinase 3 Gene

关于 RIOK3

功能概要

RIOK3 基因产物(2)

RIOK3 蛋白结构

RIOK3 蛋白互作信息

关联疾病

直系同源

热门区域

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RIOK3 - RIO kinase 3 Gene

关于 RIOK3

功能概要

RIOK3 基因产物(2)

RIOK3 蛋白结构

RIOK3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z