CASP10 - caspase 10 Gene

中文名称：半胱天冬酶 10

种属: Homo sapiens

同用名: MCH4; ALPS2; FLICE2; FLICE-2

基因 ID: 843 | 基因类型: protein coding

关于 CASP10

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:201,183,141-201,229,406 (from NCBI)

This gene has 15 transcripts (splice variants), 192 orthologues, 16 paralogues and is associated with 5 phenotypes. Broad expression in duodenum (RPKM 6.6), spleen (RPKM 5.9) and 23 other tissues.

功能概要

该基因编码的蛋白质是半胱氨酸-天冬氨酸蛋白酶 (半胱天冬酶) 家族的成员。半胱天冬酶的顺序激活在细胞凋亡的执行阶段起着核心作用。半胱天冬酶作为无活性的酶原存在，其在保守的天冬氨酸残基处进行蛋白水解加工以产生大小两个亚基，它们二聚化形成活性酶。这种蛋白质切割并激活半胱天冬酶 3 和 7，蛋白质本身由半胱天冬酶 8 加工。该基因的突变与 IIA 型自身免疫性淋巴组织增生综合征、非霍奇金淋巴瘤和胃癌有关。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2011 年 4 月]

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (Caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell Apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active Enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by Caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric Cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

CASP10 基因产物(12)

mRNA	Protein	Name
NM_001230.5	NP_001221.2	caspase-10 isoform 3 preproprotein
XR_923043.3
NM_001206524.2	NP_001193453.1	caspase-10 isoform 6 preproprotein
XR_923044.3
XM_005246907.3	XP_005246964.1	caspase-10 isoform X1
NM_001306083.2	NP_001293012.1	caspase-10 isoform 7
XM_047446016.1	XP_047301972.1	caspase-10 isoform X2
NM_001206542.2	NP_001193471.1	caspase-10 isoform 5 preproprotein
NM_032976.4	NP_116758.1	caspase-10 isoform 4
XR_007082551.1
NM_032977.4	NP_116759.2	caspase-10 isoform 1 preproprotein
NM_032974.5	NP_116756.2	caspase-10 isoform 2 preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cysteine-type endopeptidase activity	IDA IDA: 通过直接分析推断	16920334	GOA
enables cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: 通过直接分析推断	16916640	GOA
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IMP IMP: 通过突变表型推断	11717445	GOA
enables death effector domain binding	IPI IPI: 通过物理相互作用推断	11717445	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12884866	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	15069192	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: 通过突变表型推断	12884866	GOA
involved in protein maturation	IDA IDA: 通过直接分析推断	16916640	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CD95 death-inducing signaling complex	IDA IDA: 通过直接分析推断	11717445	GOA
part of ripoptosome	IDA IDA: 通过直接分析推断	21737330	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CASP10 蛋白结构

DED

Peptidase_C14

0
100
200
300
400
521 a.a.

蛋白主名

其他名称

caspase-10

CASP-10	FADD-like ICE2
FAS-associated death domain protein interleukin-1B-converting enzyme 2	ICE-like apoptotic protease 4
apoptotic protease MCH-4	caspase 10 apoptosis-related cysteine peptidase
caspase 10, apoptosis-related cysteine protease	interleukin-1B-converting enzyme 2

CASP10 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CASP10	Q92851	RIOK3	Homo sapiens	O14730	Y2H	21988832
种属内	CASP10	Q92851	RIOK3	Homo sapiens	O14730	Pull Down	21988832
种属内	CASP10	Q92851	RIOK3	Homo sapiens	O14730	Confocal	21988832
种属内	CASP10	Q92851	RIOK3	Homo sapiens	O14730	Anti Bait CoIP	19557502
种属内	CASP10	Q92851	RIPK1	Homo sapiens	Q13546	Pull Down	12884866
种属内	CASP10	Q92851	CFLAR	Homo sapiens	O15519	PLA	25241761
种属内	CASP10	Q92851	CFLAR	Homo sapiens	O15519	Anti Tag CoIP	12887920
种属内	CASP10	Q92851	XIAP	Homo sapiens	P98170	Y2H Prey Pooling	25416956
种属内	CASP10	Q92851	CASP8	Homo sapiens	Q14790	Anti Tag CoIP	12887920
种属内	CASP10	Q92851	CASP8	Homo sapiens	Q14790	FRET	11717445

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CASP10 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7742	Caspase-10/CASP10 Protein, Human (His)	Q92851-4 (V220-R472)	≥95%

关联疾病

疾病名称

别名

Hypersensitivity Reaction Type Iv Disease

Immunoproliferative Disorders

Immunoproliferative Disease

Immunodeficiency 60

Bach2-Related Immunodeficiency And Autoimmunity	Brida
Imd60

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Lymphoproliferative Syndrome

Lymphoproliferative Disorder	Lymphoproliferative Disorders
Lymphoproliferative Disorders, Susceptibility To

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma	Lymphoma, Non-Hodgkin
NHL	Lymphoma, Non-Hodgkin, Somatic
Lymphoma, Follicular, Somatic	Familial Non-Hodgkin Lymphoma
Lymphoma Non-Hodgkins	Follicular Lymphoma, Somatic
Lymphosarcoma	Non-Hodgkins Lymphoma

Autoimmune Lymphoproliferative Syndrome

ALPS	Canale-Smith Syndrome
Autoimmune Lymphoproliferative Syndrome, Type Ia	Autoimmune Lymphoproliferative Syndrome, Type Ib
Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant	Css
Autoimmune Lymphoproliferative Syndrome, Type 1b	Autoimmune Lymphoproliferative Syndrome, Type 1a
Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant	Fas Deficiency
Autoimmune Lymphoproliferative Syndrome 1a	ALPS1A
Autoimmune Lymphoproliferative Syndrome Type Ia	Autoimmune Lymphoproliferative Syndrome 1b
ALPS1B	Autoimmune Lymphoproliferative Syndrome Type Ib

Clubfoot

Congenital Clubfoot	Congenital Equinovarus
Congenital Talipes Equinovarus	Equinovarus Deformity Of Foot
Club Foot

Autoimmune Lymphoproliferative Syndrome, Type Iii

ALPS3	Autoimmune Lymphoproliferative Syndrome Type 3
Cvid9	Immunodeficiency, Common Variable, 9, Formerly
Cvid9, Formerly	Autoimmune Lymphoproliferative Syndrome Type Iii
Common Variable Immunodeficiency 9	Autoimmune Lymphoproliferative Syndrome 3
Immunodeficiency, Common Variable, 9	Type 3 Autoimmune Lymphoproliferative Syndrome
Immunodeficiency, Variable, Common, Type 9

Ras-Associated Autoimmune Leukoproliferative Disorder

RALD	Autoimmune Lymphoproliferative Syndrome Type 4
Alps4	Autoimmune Lymphoproliferative Syndrome, Type Iv
Ras-Associated Autoimmune Leukoproliferative Disease	Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic
Alps Type 4	Alps Type Iv
Autoimmune Lymphoproliferative Syndrome Type Iv	Autoimmune Lymphoproliferative Syndrome 4

Autoimmune Lymphoproliferative Syndrome, Type Iia

Autoimmune Lymphoproliferative Syndrome, Type Ii	Autoimmune Lymphoproliferative Syndrome Type 2a
ALPS2A	Alps2
Autoimmune Lymphoproliferative Syndrome Type Iia	Autoimmune Lymphoproliferative Syndrome 2a

Hemolytic Anemia

Anemia, Hemolytic	Anemia Hemolytic
Anaemia Due To Other Disorders Of Glutathione Metabolism	Chronic Non Spherocytic Anaemia
G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia	Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency
Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia	Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia
Favism Anaemia	Haemolytic Anaemia Due Tog6pd Deficiency
Favism	Pentose Phosphate Pathway Disorder Anaemia
Anaemia Due To Pentose Phosphate Pathway Defect

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Caspase 8 Deficiency

Autoimmune Lymphoproliferative Syndrome Type 2b	Ceds
Alps2b	Caspase-8 Deficiency
Autoimmune Lymphoproliferative Syndrome, Type Iib	Alps With Recurrent Viral Infections
Autoimmune Lymphoproliferative Syndrome With Recurrent Viral Infections	Caspase 8 Deficiency Syndrome
Autoimmune Lymphoproliferative Syndrome Type Iib	Caspase Eight Deficiency State
CASP8D

Gastric Cancer

Stomach Cancer	Stomach Carcinoma
Gastric Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

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CASP10 - caspase 10 Gene

关于 CASP10

功能概要

CASP10 基因产物(12)

CASP10 蛋白结构

CASP10 蛋白互作信息

重组 CASP10 蛋白

关联疾病

热门区域

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CASP10 - caspase 10 Gene

关于 CASP10

功能概要

CASP10 基因产物(12)

CASP10 蛋白结构

CASP10 蛋白互作信息

重组 CASP10 蛋白

关联疾病

相关产品

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z