FUBP1 - far upstream element binding protein 1 Gene

中文名称：远上游元件结合蛋白 1

种属: Homo sapiens

同用名: FBP; FUBP; hDH V

关于 FUBP1

功能概要

该基因编码的蛋白质是一种单链 DNA 结合蛋白，可与多个 DNA 元件结合，包括位于 c-Myc 上游的远上游元件 (FUSE) 。与 FUSE 的结合发生在非编码链上，对未分化细胞中 c-Myc 的调节很重要。该蛋白质包含三个结构域，一个两亲性螺旋 N 末端结构域、一个 DNA 结合中心结构域和一个包含三个富含酪氨酸的基序的 C 末端反式激活结构域。 N 端结构域被认为抑制 C 端结构域的活性。这种蛋白质也被认为可以结合 RNA，并且含有 3'-5' 解旋酶活性，对 DNA-DNA 和 RNA-RNA 双链体具有体外活性。已在恶性组织中发现该基因的异常表达，该基因对神经系统和肺发育具有重要意义。这种蛋白质与病毒 RNA 的结合被认为在几种病毒性疾病中起作用，包括丙型肝炎和手足口病。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 12 月]

The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-Myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-Myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]