RPL14 - ribosomal protein L14 Gene

中文名称：核糖体蛋白 L14

种属: Homo sapiens

同用名: L14; RL14; hRL14; CTG-B33; CAG-ISL-7

基因 ID: 9045 | 基因类型: protein coding

关于 RPL14

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:40,457,339-40,468,587 (from NCBI)

This gene has 9 transcripts (splice variants) and 242 orthologues. Ubiquitous expression in ovary (RPKM 576.2), lymph node (RPKM 328.7) and 25 other tissues.

功能概要

核糖体是催化蛋白质合成的细胞器，由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码的核糖体蛋白是 60S 亚基的一个组成部分。该蛋白属于核糖体蛋白 L14E 家族。它包含一个基本区域亮氨酸拉链 (bZIP) 样域。该蛋白质位于细胞质中。该基因包含一个三核苷酸 (GCT) 重复片段，其长度具有高度多态性；这些三联体重复在编码的蛋白质中产生一段丙氨酸残基。存在利用替代 polyA 信号和替代 5'-末端外显子的转录变体，但都编码相同的蛋白质。作为典型的编码核糖体蛋白的基因，该基因有多个经过处理的假基因分散在基因组中。[RefSeq 提供，2008 年 7 月]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPL14 基因产物(2)

mRNA	Protein	Name
NM_001034996.3	NP_001030168.1	60S ribosomal protein L14
NM_003973.5	NP_003964.3	60S ribosomal protein L14

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11369516	GOA
enables structural constituent of ribosome	IDA IDA: 通过直接分析推断	23636399	GOA
enables structural constituent of ribosome	IMP IMP: 通过突变表型推断	18697920	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in rRNA processing	IMP IMP: 通过突变表型推断	18697920	GOA
involved in ribosomal large subunit biogenesis	IMP IMP: 通过突变表型推断	18697920	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of cytosolic large ribosomal subunit	IDA IDA: 通过直接分析推断	32669547	GOA
part of cytosolic large ribosomal subunit	IPI IPI: 通过物理相互作用推断	25901680	GOA
located in cytosolic ribosome	IDA IDA: 通过直接分析推断	23636399	GOA
is active in postsynaptic density	EXP EXP: 通过实验结果推断	21170055	GOA
is active in postsynaptic density	IDA IDA: 通过直接分析推断	21170055	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPL14 蛋白结构

Ribosomal_L14e

0
100
200
215 a.a.

蛋白主名

其他名称

60S ribosomal protein L14

large ribosomal subunit protein eL14

RPL14 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RPL14	P50914	RPL4	Homo sapiens	P36578	Anti Tag CoIP	33961781
种属内	RPL14	P50914	RPL4	Homo sapiens	P36578	Anti Tag CoIP	28514442
种属内	RPL14	P50914	H1-4	Homo sapiens	P10412	Anti Tag CoIP	33961781
种属内	RPL14	P50914	H1-4	Homo sapiens	P10412	Crosslink	30021884
种属内	RPL14	P50914	PHLDA1	Homo sapiens	Q8WV24	Pull Down	11369516
种属内	RPL14	P50914	PHLDA1	Homo sapiens	Q8WV24	Y2H	11369516

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cardiomyopathy, Familial Hypertrophic, 15

Hypertrophic Cardiomyopathy 15	CMH15
Cardiomyopathy, Hypertrophic, 15	Cardiomyopathy Familial Hypertrophic 15
Cardiomyopathy, Familial Hypertrophic 15	Cardiomyopathy, Hypertrophic, Familial, Type 15

Cardiac Valvular Dysplasia, X-Linked

Xmvd	X-Linked Cardiac Valvular Dysplasia
CVD1	Filamin A-Related X-Linked Myxomatous Valvular Dysplasia
Flna-Related Valvular Dystrophy	Flna-Related X-Linked Myxomatous Valvular Dysplasia
Valvular Heart Disease, Congenital	Myxomatous Valvular Dystrophy, X-Linked
Congenital Valvular Heart Disease	X-Linked Myxomatous Valvular Dystrophy
CVDPX	Ehlers-Danlos Syndrome, Type V, Formerly
Eds5, Formerly	Dystrophie Valvulaire Associee A Flna
Eds 5	Ehlers-Danlos Syndrome, Type 5
Dystrophie Valvulaire Associée À Flna	Filamin-A-Associated Myxomatous Mitral Valve Disease
Filamin-A-Related Myxomatous Mitral Valve Dystrophy	Congenital Valvular Dysplasia
Cvdx	Ehlers-Danlos Syndrome Type 5

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12166	RPL14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	RPL14	VGNC	VGNC:34110
Mus musculus	RPL14	MGD	MGI:1914365
Rattus norvegicus	RPL14	RGD	RGD:621180

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