DPP9 - dipeptidyl peptidase 9 Gene

中文名称：二肽基肽酶 9

种属: Homo sapiens

同用名: DP9; DPLP9; DPRP2; DPP IX; DPRP-2

关于 DPP9

功能概要

该基因编码的蛋白质是丝氨酸蛋白酶家族 SC 中 S9B 家族的成员。该蛋白质已被证明具有后脯氨酸二肽氨肽酶活性，可从蛋白质的 N 末端切割 Xaa-Pro 二肽。虽然这种蛋白质的活性与二肽基肽酶 4 (DPP4) 的活性相似，但它似乎不是膜结合的。一般而言，二肽基肽酶似乎参与其底物活性的调节，并与多种疾病有关，包括 2 型糖尿病、肥胖症和癌症。已经描述了该基因的几种转录变体，但尚未完全表征。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl Aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of Dipeptidyl Peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and Cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]