PRPF4 - pre-mRNA processing factor 4 Gene

中文名称：pre-mRNA 加工因子 4

种属: Homo sapiens

同用名: PRP4; RP70; HPRP4; Prp4p; HPRP4P; SNRNP60

基因 ID: 9128 | 基因类型: protein coding

关于 PRPF4

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:113,275,658-113,292,905 (from NCBI)

This gene has 3 transcripts (splice variants), 207 orthologues and is associated with 3 phenotypes. Ubiquitous expression in appendix (RPKM 8.9), kidney (RPKM 8.4) and 25 other tissues.

功能概要

由该基因编码的蛋白质是结合 U4、U5 和 U6 小核 RNA 的异聚复合物的一部分，并参与 pre-mRNA 剪接。编码的蛋白质也是有丝分裂检查点蛋白和人类卵巢癌化疗耐药的调节剂。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2016 年 4 月]

The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian Cancer. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]

PRPF4 基因产物(4)

mRNA	Protein	Name
NM_001244926.2	NP_001231855.1	U4/U6 small nuclear ribonucleoprotein Prp4 isoform 2
NM_001322266.2	NP_001309195.1	U4/U6 small nuclear ribonucleoprotein Prp4 isoform 3
NM_001322267.2	NP_001309196.1	U4/U6 small nuclear ribonucleoprotein Prp4 isoform 3
NM_004697.5	NP_004688.2	U4/U6 small nuclear ribonucleoprotein Prp4 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	9570313	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mRNA splicing, via spliceosome	IDA IDA: 通过直接分析推断	28781166	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Cajal body	IDA IDA: 通过直接分析推断	15257298	GOA
part of U2-type precatalytic spliceosome	IDA IDA: 通过直接分析推断	28781166	GOA
part of U4/U6 snRNP	IDA IDA: 通过直接分析推断	9570313	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: 通过直接分析推断	23793891	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: 通过物理相互作用推断	30975767	GOA
located in nuclear speck	IDA IDA: 通过直接分析推断	25383878	GOA
located in nucleus	IDA IDA: 通过直接分析推断	28781166	GOA
part of spliceosomal snRNP complex	IDA IDA: 通过直接分析推断	25383878	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRPF4 蛋白结构

PRP4

WD40

0
100
200
300
400
522 a.a.

蛋白主名

其他名称

U4/U6 small nuclear ribonucleoprotein Prp4

PRP4 homolog

PRPF4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PRPF4	O43172	PPIH	Homo sapiens	O43447	Anti Tag CoIP	19615732
种属内	PRPF4	O43172	PPIH	Homo sapiens	O43447	Anti Tag CoIP	33961781
种属内	PRPF4	O43172	PPIH	Homo sapiens	O43447	Y2H	16723661
种属内	PRPF4	O43172	PPIH	Homo sapiens	O43447	BRET	29997244
种属内	PRPF4	O43172	GPKOW	Homo sapiens	Q92917	Y2H	22365833

种属间: 跨种属相互作用 种属内: 同种属相互作用

PRPF4 抗体

目录号	产品名	应用	反应物种
HY-P82012	PRPF4 Antibody (YA1757)	WB, IP	Human, Mouse

关联疾病

疾病名称

别名

Retinitis Pigmentosa 70

RP70	Retinitis Pigmentosa, Type 70

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Retinitis Pigmentosa 33

RP33	Retinitis Pigmentosa, Type 33

Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome	Syndromic Diarrhea
Tricho-Hepato-Enteric Syndrome	Sd/The
Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome	THES1
Phenotypic Diarrhea	Thes
Phenotypic Diarrhea Of Infancy	Diarrhea, Syndromic
Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa	Intractable Diarrhea With Phenotypic Anomalies
Syndromatic Diarrhea	Fatal Infantile Diarrhea With Trichorrhexis Nodosa

Trichohepatoenteric Syndrome 2

THES2

Night Blindness, Congenital Stationary, Autosomal Dominant 1

Congenital Stationary Night Blindness Autosomal Dominant 1	CSNBAD1
Rhodopsin-Related Congenital Stationary Night Blindness	Night Blindness, Congenital Stationary, Rhodopsin-Related
Blindness, Night, Stationary, Congenital, Autosomal Dominant, Type 1

Microcephalic Osteodysplastic Primordial Dwarfism, Type I

Taybi-Linder Syndrome	Brachymelic Primordial Dwarfism
Cephaloskeletal Dysplasia	Low-Birth-Weight Dwarfism With Skeletal Dysplasia
Microcephalic Osteodysplastic Primordial Dwarfism Type I	Osteodysplastic Primordial Dwarfism Type I
Primordial Microcephalic Dwarfism, Crachami Type	Osteodysplastic Primordial Dwarfism, Type 1
MOPD1	Mopd I
Mopd	Osteodysplastic Primordial Dwarfism, Type I
Tals	Microcephalic Osteodysplastic Primordial Dwarfism Type 1
Mopd 1	Microcephalic Osteodysplastic Primordial Dwarfism Types 1 And 3
Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii	Mopd Types I And Iii
Microcephalic Osteodysplastic Primordial Dwarfism, Taybi-Linder Type	Primordial Microcephalic Dwarfism Crachami Type
Dwarfism, Primordial, Osteodysplastic, Microcephalic, Type 1

Mandibulofacial Dysostosis, Guion-Almeida Type

Mandibulofacial Dysostosis With Microcephaly	Mandibulofacial Dysostosis-Microcephaly Syndrome
MFDGA	MFDM
Mfdm Syndrome	Growth And Mental Retardation, Mandibulofacial Dysostosis, Microcephaly, And Cleft Palate
Growth Delay - Intellectual Disability - Mandibulofacial Dysostosis - Microcephaly - Cleft Palate	Growth Delay-Intellectual Disability-Mandibulofacial Dysostosis-Microcephaly-Cleft Palate Syndrome
Dysostosis, Mandibulofacial, Guion-Almeida Type

Burn-Mckeown Syndrome

Choanal Atresia-Hearing Loss-Cardiac Defects-Craniofacial Dysmorphism Syndrome	Oculootofacial Dysplasia
BMKS	Oofd
Bilateral Choanal Atresia, Cardiac Defects, Deafness, And Dysmorphic Appearance	Choanal Atresia - Deafness - Cardiac Defects - Dysmorphism Syndrome
Choanal Atresia Deafness Cardiac Defects Dysmorphism	Oculo-Oto-Facial Dysplasia

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Leber Plus Disease

Leber Congenital Amaurosis	Lca
Leber'S Amaurosis	Leber'S Disease
Amaurosis Congenita Of Leber	Amaurosis Congenita Of Leber, Type 1
Lhon Plus Disease	Congenital Absence Of The Rods And Cones
Congenital Retinal Blindness	Crb
Congenital Amaurosis Of Retinal Origin	Leber'S Congenital Amaurosis
Leber Congenital Amaurosis 1	Leber'S Congenital Tapetoretinal Degeneration
Leber'S Congenital Tapetoretinal Dysplasia	Lca1
Leber Congenital Amaurosis Type 1	Retinal Blindness, Congenital
Amaurosis, Leber Congenital	Dysgenesis Neuroepithelialis Retinae
Hereditary Epithelial Dysplasia Of Retina	Hereditary Retinal Aplasia
Heredoretinopathia Congenitalis	Leber Abiotrophy
Leber Congenital Tapetoretinal Degeneration	Lebers Congenital Amaurosis
Optic Atrophy, Hereditary, Leber

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11211	PRPF4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS11214	PRPF4B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	PRPF4	VGNC	VGNC:64374
Bos taurus	PRPF4	VGNC	VGNC:33378
Mus musculus	PRPF4	MGD	MGI:1917302
Macaca mulatta	PRPF4	VGNC	VGNC:76278
Canis familiaris	PRPF4	VGNC	VGNC:45025
Rattus norvegicus	PRPF4	RGD	RGD:1311303
Others	PRPF4	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PRPF4 - pre-mRNA processing factor 4 Gene

关于 PRPF4

功能概要

PRPF4 基因产物(4)

PRPF4 蛋白结构

PRPF4 蛋白互作信息

PRPF4 抗体

关联疾病

直系同源

热门区域

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PRPF4 - pre-mRNA processing factor 4 Gene

关于 PRPF4

功能概要

PRPF4 基因产物(4)

PRPF4 蛋白结构

PRPF4 蛋白互作信息

PRPF4 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z