ZMYM3 - zinc finger MYM-type containing 3 Gene

中文名称：含锌指 MYM 型 3

种属: Homo sapiens

同用名: MYM; XFIM; ZNF261; DXS6673E; ZNF198L2

关于 ZMYM3

功能概要

该基因位于 X 染色体上，会发生 X 失活。它在脊椎动物中高度保守，在大脑中表达最丰富。编码的蛋白质是含有组蛋白去乙酰化酶的多蛋白复合物的一个组成部分，它通过修饰染色质结构发挥作用，使基因保持沉默。涉及该基因的染色体易位 (X;13) 与 X 连锁认知障碍有关。已发现该基因的几种可变剪接转录物变体。[RefSeq 提供，2010 年 1 月]

This gene is located on the X chromosome and is subject to X inactivation. It is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that function through modifying chromatin structure to keep genes silent. A chromosomal translocation (X;13) involving this gene is associated with X-linked cognitive disability. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2010]