MTDH - metadherin Gene

中文名称：元粘着素

种属: Homo sapiens

同用名: 3D3; AEG1; AEG-1; LYRIC; LYRIC/3D3

基因 ID: 92140 | 基因类型: protein coding

关于 MTDH

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:97,644,184-97,730,260 (from NCBI)

This gene has 6 transcripts (splice variants), 129 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 24.7), bone marrow (RPKM 21.0) and 25 other tissues.

功能概要

启用 NF-kappaB 绑定活动；双链 RNA 结合活性；和转录共激活因子活性。参与多个过程，包括脂多糖介导的信号通路；细胞内信号转导的正向调节；和转录调控，DNA 模板化。位于内质网；核腔;和细胞质的核周区。与肝细胞癌有关。 [由基因组资源联盟提供，2022 年 4 月]

Enables NF-kappaB binding activity; double-stranded RNA binding activity; and transcription coactivator activity. Involved in several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of intracellular signal transduction; and regulation of transcription, DNA-templated. Located in endoplasmic reticulum; nuclear lumen; and perinuclear region of cytoplasm. Implicated in hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

MTDH 基因产物(5)

mRNA	Protein	Name
NM_001363136.1	NP_001350065.1	protein LYRIC isoform 2
NM_001363137.1	NP_001350066.1	protein LYRIC isoform 3
NM_001363138.1	NP_001350067.1	protein LYRIC isoform 4
NM_001363139.1	NP_001350068.1	protein LYRIC isoform 5
NM_178812.4	NP_848927.2	protein LYRIC isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables NF-kappaB binding	IPI IPI: 通过物理相互作用推断	16452207	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	18316612	GOA
enables double-stranded RNA binding	IDA IDA: 通过直接分析推断	21266579	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	18316612	GOA
enables transcription coactivator activity	IMP IMP: 通过突变表型推断	18316612	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in lipopolysaccharide-mediated signaling pathway	IMP IMP: 通过突变表型推断	19740331	GOA
involved in negative regulation of apoptotic process	IDA IDA: 通过直接分析推断	17704808	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	15927426	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: 通过直接分析推断	16452207	GOA
involved in positive regulation of angiogenesis	IDA IDA: 通过直接分析推断	19940250	GOA
involved in positive regulation of autophagy	IDA IDA: 通过直接分析推断	21127263	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: 通过直接分析推断	16452207	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: 通过直接分析推断	17704808	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	19648967	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	14980505	GOA
located in nuclear body	IDA IDA: 通过直接分析推断	19648967	GOA
located in nucleus	IDA IDA: 通过直接分析推断	16452207	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	14980505	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

protein LYRIC

3D3/LYRIC

MTDH 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MTDH	Q86UE4	SND1	Homo sapiens	Q7KZF4	Anti Tag CoIP	33961781
种属内	MTDH	Q86UE4	SND1	Homo sapiens	Q7KZF4	Anti Tag CoIP	28514442
种属内	MTDH	Q86UE4	SND1	Homo sapiens	Q7KZF4	Anti Tag CoIP	24981741
种属内	MTDH	Q86UE4	SND1	Homo sapiens	Q7KZF4	Anti Tag CoIP	34591612
种属内	MTDH	Q86UE4	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	24981741

种属间: 跨种属相互作用 种属内: 同种属相互作用

MTDH 抗体

目录号	产品名	应用	反应物种
HY-P81286	LYRIC Antibody (YA995)	WB, IHC-P, FC	Human
HY-P81286A	LYRIC Antibody (YA996)	WB, IHC-F, IHC-P, ICC/IF, IP	Human

关联疾病

疾病名称

别名

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

High Grade Glioma

Malignant Glioma	Glial Cell Tumor
Glioma, Malignant	Malignant Neuroglial Tumor
Neuroglial Tumor	Glioma
Malignant Gliomas

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Migraine, Familial Hemiplegic, 2

FHM2	Mhp2
Migraine, Familial Basilar	Familial Hemiplegic Migraine 2
Familial Hemiplegic Migraine-2	Familiar Basilar Migraine
Migraine, Hemiplegic, Familial, Type 2

Cataract 30

Cataract 30 Pulverulent	Cataract Coppock-Like
Ctrct30	Dusty Cataract
Cataract, Type 30

Migraine, Familial Hemiplegic, 3

FHM3	Familial Hemiplegic Migraine 3
Mhp3	Migraine, Hemiplegic, Familial, Type 3

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-155170	MTDH-SND1 blocker 1	Inhibitor	98.30%	否
HY-160801	HKYK-0030	Inhibitor	99.38%	否
HY-RS08762	MTDH Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	MTDH	MGD	MGI:1914404
Canis familiaris	MTDH	VGNC	VGNC:43462
Macaca mulatta	MTDH	VGNC	VGNC:74859
Felis catus	MTDH	VGNC	VGNC:63643
Bos taurus	MTDH	VGNC	VGNC:31719
Rattus norvegicus	MTDH	RGD	RGD:620992

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