SND1 - staphylococcal nuclease and tudor domain containing 1 Gene

中文名称：含葡萄球菌核酸酶和 Tudor 结构域 1

种属: Homo sapiens

同用名: p100; TDRD11; Tudor-SN

基因 ID: 27044 | 基因类型: protein coding

关于 SND1

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:127,652,194-128,092,593 (from NCBI)

This gene has 16 transcripts (splice variants), 199 orthologues, 1 paralogue and is associated with 81 phenotypes. Ubiquitous expression in placenta (RPKM 45.9), thyroid (RPKM 41.6) and 25 other tissues.

功能概要

该基因编码的转录共激活因子与 EB 病毒核抗原 2 (EBNA 2) 的酸性结构域相互作用，EBNA 2 是 B 淋巴细胞转化所需的转录激活因子。与这种蛋白质相互作用的其他转录因子是信号转导和转录激活因子，STAT。这种蛋白质也被认为是正常细胞生长所必需的。哺乳动物和其他生物体中的一种类似蛋白质是 RNA 诱导的沉默复合物 (RISC) 的组成部分。[RefSeq 提供，2016 年 7 月]

This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and Other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016]

SND1 基因产物(1)

mRNA	Protein	Name
NM_014390.4	NP_055205.2	staphylococcal nuclease domain-containing protein 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RISC complex binding	IDA IDA: 通过直接分析推断	28546213	GOA
enables RNA binding	IDA IDA: 通过直接分析推断	18453631	GOA
enables RNA endonuclease activity	IDA IDA: 通过直接分析推断	28546213	GOA
enables endonuclease activity	IDA IDA: 通过直接分析推断	18453631	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20643132	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in miRNA catabolic process	IDA IDA: 通过直接分析推断	28546213	GOA
involved in regulation of cell cycle process	IMP IMP: 通过突变表型推断	28546213	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SND1 蛋白结构

SNase

TUDOR

SNase

0
200
400
600
800
910 a.a.

蛋白主名

其他名称

staphylococcal nuclease domain-containing protein 1

EBNA2 coactivator p100

SND1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SND1	Q7KZF4	MTDH	Homo sapiens	Q86UE4	Anti Bait CoIP	24981741
种属内	SND1	Q7KZF4	MTDH	Homo sapiens	Q86UE4	Anti Tag CoIP	24981741
种属内	SND1	Q7KZF4	MTDH	Homo sapiens	Q86UE4	Pull Down	24981741
种属内	SND1	Q7KZF4	G3BP1	Homo sapiens	Q13283	Anti Bait CoIP	20643132
种属内	SND1	Q7KZF4	PIWIL1	Homo sapiens	Q96J94	FPS	20937909
种属内	SND1	Q7KZF4	PIWIL1	Homo sapiens	Q96J94	ITC	20937909
种属内	SND1	Q7KZF4	PIWIL1	Homo sapiens	Q96J94	X-Ray Diffraction	20937909

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Posterior Pituitary Gland Neoplasm

Posterior Pituitary Tumor

Neoplasm Of The Posterior Pituitary

Pancreatic Acinar Cell Adenocarcinoma

Pancreatic Acinar Cell Carcinoma

Acinar Cell Adenocarcinoma Of The Pancreas

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-115581A	Thymidine 3',5'-diphosphate tetrasodium		≥97.0%	否
HY-155170	MTDH-SND1 blocker 1		98.30%	否
HY-160801	HKYK-0030	Inhibitor	99.38%	否
HY-RS13488	SND1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-115581	Thymidine 3',5'-disphosphate	Inducer	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	SND1	MGD	MGI:1929266
Rattus norvegicus	SND1	RGD	RGD:631340
Bos taurus	SND1	VGNC	VGNC:35063
Macaca mulatta	SND1	VGNC	VGNC:77798
Felis catus	SND1	VGNC	VGNC:65528
Canis familiaris	SND1	VGNC	VGNC:46600

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