CD6 - CD6 molecule Gene

中文名称：CD6 分子

种属: Homo sapiens

同用名: TP120

基因 ID: 923 | 基因类型: protein coding

关于 CD6

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,971,680-61,020,377 (from NCBI)

This gene has 14 transcripts (splice variants), 139 orthologues and 15 paralogues. Biased expression in lymph node (RPKM 22.7), appendix (RPKM 13.7) and 9 other tissues.

功能概要

该基因编码一种在 T 淋巴细胞和其他一些免疫细胞外膜上发现的蛋白质。编码的蛋白质包含三个清道夫受体富含半胱氨酸 (SRCR) 结构域和一个活化白细胞粘附分子的结合位点。该基因产物对于 T 细胞激活的持续性很重要。该基因可能与多发性硬化症的易感性有关 (PMID：19525953、21849685) 。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 12 月]

This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some Other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

CD6 基因产物(3)

mRNA	Protein	Name
NM_001254750.2	NP_001241679.1	T-cell differentiation antigen CD6 isoform 2 precursor
NM_001254751.2	NP_001241680.1	T-cell differentiation antigen CD6 isoform 3 precursor
NM_006725.5	NP_006716.3	T-cell differentiation antigen CD6 isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	26146185	GOA
enables lipopolysaccharide binding	IDA IDA: 通过直接分析推断	17601777	GOA
enables lipoteichoic acid binding	IMP IMP: 通过突变表型推断	17601777	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	24584089	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in acute inflammatory response to antigenic stimulus	IDA IDA: 通过直接分析推断	17601777	GOA
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP IMP: 通过突变表型推断	16352806	GOA
involved in immunological synapse formation	IMP IMP: 通过突变表型推断	15294938	GOA
involved in lipopolysaccharide-mediated signaling pathway	IDA IDA: 通过直接分析推断	17601777	GOA
involved in positive regulation of T cell proliferation	IMP IMP: 通过突变表型推断	15294938	GOA
involved in positive regulation of cytokine production involved in inflammatory response	IDA IDA: 通过直接分析推断	17601777	GOA
involved in response to lipopolysaccharide	IDA IDA: 通过直接分析推断	17601777	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of T cell receptor complex	IDA IDA: 通过直接分析推断	15294938	GOA
located in immunological synapse	IDA IDA: 通过直接分析推断	15294938	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	15294938	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CD6 蛋白结构

SRCR

0
200
400
600
668 a.a.

蛋白主名

其他名称

T-cell differentiation antigen CD6

CD6 antigen

CD6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CD6	P30203	LGALS3	Homo sapiens	P17931	Pull Down	24945728
种属内	CD6	P30203	LGALS3	Homo sapiens	P17931	ELISA	24945728
种属内	CD6	P30203	ALCAM	Homo sapiens	Q13740	SLCA	26146185
种属内	CD6	P30203	ALCAM	Homo sapiens	Q13740	Light Scattering	26146185
种属内	CD6	P30203	ALCAM	Homo sapiens	Q13740	GMS	26146185
种属内	CD6	P30203	ALCAM	Homo sapiens	Q13740	Anti Tag CoIP	33961781
种属内	CD6	P30203	acn	Yersinia pestis	A0A380PDG1	Y2H Pooling	20711500
种属内	CD6	P30203	CD6	Homo sapiens	P30203	SLCA	26146185
种属内	CD6	P30203	LCP2	Homo sapiens	Q13094	Anti Bait CoIP	24584089
种属内	CD6	P30203	Sdcbp	Mus musculus	O08992	Y2H Array	16034076
种属内	CD6	P30203	CD6	Homo sapiens	P30203	GMS	26146185
种属内	CD6	P30203	Sdcbp	Mus musculus	O08992	Anti Bait CoIP	16034076
种属内	CD6	P30203	Sdcbp	Mus musculus	O08992	Pull Down	16034076
种属内	CD6	P30203	CD6	Homo sapiens	P30203	Light Scattering	26146185
种属内	CD6	P30203	GYG1	Homo sapiens	P46976	Y2H Array	21988832

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CD6 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72922	CD6 Protein, Human (HEK293, Fc)	P30203 (H18-E398)	≥95%
HY-P700684	CD6 Protein, Human (HEK293, His)	NP_006716.3 (H18-L402)	≥95%

关联疾病

疾病名称

别名

Inflammatory Bowel Disease 16

IBD16

Inflammatory Bowel Disease 16, Susceptibility To

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Inflammatory Bowel Disease 18

IBD18

Diamond-Blackfan Anemia 1

Aase Syndrome	DBA1
Erythrogenesis Imperfecta	Aase-Smith Syndrome Ii
Dba	Blackfan-Diamond Syndrome
Bds	Anemia, Congenital Hypoplastic, Of Blackfan And Diamond
Anemia, Congenital Erythroid Hypoplastic	Red Cell Aplasia, Pure, Hereditary
Aregenerative Anemia, Chronic Congenital	Rps19-Related Diamond-Blackfan Anemia
Chronic Congenital Aregenerative Anemia	Congenital Erythroid Hypoplastic Anemia
Congenital Hypoplastic Anemia Of Blackfan And Diamond	Pure Hereditary Red Cell Aplasia
Anemia, Diamond-Blackfan, Type 1	Anemia, Diamond-Blackfan
Aase Smith Syndrome 2	Familial Hypoplastic Anaemia With Malformations
Constitutional Pure Red Cell Aplasia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-P99252	Itolizumab		≥99.0%	Phase 3

直系同源

种属	基因名	来源	基因 ID
Felis catus	CD6	VGNC	VGNC:60635
Rattus norvegicus	CD6	RGD	RGD:2312
Canis familiaris	CD6	VGNC	VGNC:38966
Mus musculus	CD6	MGD	MGI:103566
Macaca mulatta	CD6	VGNC	VGNC:100906
Bos taurus	CD6	VGNC	VGNC:27041
Macaca fascicularis	CD6	NCBI	NCBI:102143944
Susscrofa domestica	CD6	NCBI
Leporidae	CD6	NCBI
Others	CD6	NCBI

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站点地图隐私声明

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CD6 - CD6 molecule Gene

关于 CD6

功能概要

CD6 基因产物(3)

CD6 蛋白结构

CD6 蛋白互作信息

重组 CD6 蛋白

关联疾病

直系同源

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CD6 - CD6 molecule Gene

关于 CD6

功能概要

CD6 基因产物(3)

CD6 蛋白结构

CD6 蛋白互作信息

重组 CD6 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z