2. Gene
  3. STRADA - STE20 related adaptor alpha Gene

STRADA - STE20 related adaptor alpha Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：STE20 相关适配器 alpha

种属: Homo sapiens

同用名: LYK5; PMSE; Stlk; STRAD; NY-BR-96; STRAD alpha

基因 ID: 92335 | 基因类型: protein coding

关于 STRADA

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,702,832-63,741,986 (from NCBI)

This gene has 54 transcripts (splice variants), 212 orthologues, 35 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 18.6), brain (RPKM 8.0) and 24 other tissues.

功能概要

该基因编码的蛋白质包含一个类似 STE20 的激酶结构域，但缺少几个对催化活性至关重要的残基，因此它被称为“伪激酶”。该蛋白与丝氨酸/苏氨酸激酶 11 (STK11，也称为 LKB1) 和支架蛋白钙结合蛋白 39 (CAB39，也称为 MO25) 形成异源三聚体复合物。该蛋白质激活 STK11，导致两种蛋白质磷酸化，并将 STK11 从细胞核中排除。该蛋白是 STK11 诱导的 G1 细胞周期停滞所必需的。该基因的突变已被证明会导致羊水过多、巨脑畸形和症状性癫痫 (PMSE) 综合征。已发现该基因编码不同异构体的多个转录变体。已经描述了其他转录本变体，但它们的全长性质尚不清楚。[RefSeq 提供，2009 年 9 月]

The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]

STRADA 基因产物(15)

mRNA Protein Name
NM_001003786.3 NP_001003786.1 STE20-related kinase adapter protein alpha isoform 2
NM_001003787.4 NP_001003787.1 STE20-related kinase adapter protein alpha isoform 1
NM_001003788.3 NP_001003788.1 STE20-related kinase adapter protein alpha isoform 4
NM_001165969.2 NP_001159441.1 STE20-related kinase adapter protein alpha isoform 5
NM_001165970.2 NP_001159442.1 STE20-related kinase adapter protein alpha isoform 6
NM_001363786.1 NP_001350715.1 STE20-related kinase adapter protein alpha isoform 7
NM_001363787.1 NP_001350716.1 STE20-related kinase adapter protein alpha isoform 8
NM_001363788.1 NP_001350717.1 STE20-related kinase adapter protein alpha isoform 9
NM_001363789.1 NP_001350718.1 STE20-related kinase adapter protein alpha isoform 10
NM_001363790.1 NP_001350719.1 STE20-related kinase adapter protein alpha isoform 11
NM_001363791.1 NP_001350720.1 STE20-related kinase adapter protein alpha isoform 12
NM_001411083.1 NP_001398012.1 STE20-related kinase adapter protein alpha isoform 13
NM_001411084.1 NP_001398013.1 STE20-related kinase adapter protein alpha isoform 14
NM_001411085.1 NP_001398014.1 STE20-related kinase adapter protein alpha isoform 15
NM_153335.6 NP_699166.2 STE20-related kinase adapter protein alpha isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables kinase binding IPI
IPI: 通过物理相互作用推断
19892943 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12805220 GOA
enables protein kinase activator activity IDA
IDA: 通过直接分析推断
19892943 GOA
NOT enables protein kinase activity IDA
IDA: 通过直接分析推断
12805220 GOA
enables protein serine/threonine kinase activator activity IDA
IDA: 通过直接分析推断
12805220 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of negative effect G1 to G0 transition IPI
IPI: 通过物理相互作用推断
12805220 GOA
involved in activation of protein kinase activity IDA
IDA: 通过直接分析推断
12805220 GOA
involved in protein export from nucleus IDA
IDA: 通过直接分析推断
12805220 GOA
NOT involved in protein phosphorylation IDA
IDA: 通过直接分析推断
12805220 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12805220 GOA
part of intracellular protein-containing complex IDA
IDA: 通过直接分析推断
12805220 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12805220 GOA
part of serine/threonine protein kinase complex IPI
IPI: 通过物理相互作用推断
19892943 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STRADA 蛋白结构

Pkinase

Pkinase: Protein kinase domain (69 - 379)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
蛋白主名 其他名称

STE20-related kinase adapter protein alpha

STE20-like pseudokinase

STRADA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
STRADA Q7RTN6 STK11 Homo sapiens Q15831
Anti Bait CoIP
12805220
种属内
STRADA Q7RTN6 STK11 Homo sapiens Q15831
IF
12805220
种属内
STRADA Q7RTN6 STK11 Homo sapiens Q15831
Affinity Chrom
15733851
种属内
STRADA Q7RTN6 STK11 Homo sapiens Q15831
Y2H
12805220
种属内
STRADA Q7RTN6 STK11 Homo sapiens Q15831
Anti Tag CoIP
12805220
种属内
STRADA Q7RTN6 CAB39 Homo sapiens Q9Y376
Anti Tag CoIP
21423148
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Polyhydramnios, Megalencephaly, And Symptomatic Epilepsy

Pmse Syndrome

PMSE

Polyhydramnios, Megalencephaly, And Symptomatic Epilepsy Syndrome

Pretzel Syndrome

Polyhydramnios-Megalencephaly-Symptomatic Epilepsy Syndrome
Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy

Benign Rolandic Epilepsy

Epilepsy, Rolandic

Bcects

Benign Childhood Epilepsy With Centrotemporal Spike

Sylvan Seizures

Becrs

Bects

Bre

Benign Epilepsy Of Childhood With Centrotemporal Spikes

Benign Familial Epilepsy Of Childhood With Rolandic Spikes

Centrotemporal Epilepsy
Megalencephaly

Macroencephaly

Macrencephaly
Polyhydramnios
Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders
Scheuermann Disease

Scheuermann'S Disease

Spinal Osteochondrosis

Juvenile Osteochondrosis Of Spine

Familial Scheuermann Disease

Familial Scheuermann Juvenile Kyphosis

Familial Spinal Osteochondrosis

Scheuermann Juvenile Kyphosis

Juvenile Osteochondritis Of The Spine

Juvenile Osteochondrosis Of Scheurermann

Scheuermann'S Kyphosis

Sherman'S Disease

Juvenile Kyphosis

Scheuermann Kyphosis

[X]Spinal Osteochondrosis, Unspecified
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13959 STRADA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus STRADA VGNC VGNC:35418
Canis familiaris STRADA VGNC VGNC:46939
Macaca mulatta STRADA VGNC VGNC:81589
Mus musculus STRADA MGD MGI:1919399
Rattus norvegicus STRADA RGD RGD:727905
Felis catus STRADA VGNC VGNC:97649
Others STRADA NCBI
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