2. Gene
  3. GPR55 - G protein-coupled receptor 55 Gene

GPR55 - G protein-coupled receptor 55 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体 55

种属: Homo sapiens

同用名: LPIR1

基因 ID: 9290 | 基因类型: protein coding

关于 GPR55

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:230,907,328-230,961,201 (from NCBI)

This gene has 6 transcripts (splice variants), 182 orthologues and 16 paralogues. Biased expression in testis (RPKM 2.7), spleen (RPKM 2.0) and 13 other tissues.

功能概要

该基因属于 G 蛋白偶联受体超家族。编码的整合膜蛋白可能是大麻素受体。它可能通过激活多种信号转导通路参与多种生理和病理过程。[RefSeq 提供，2013 年 8 月]

This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely Cannabinoid Receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013]

GPR55 基因产物(4)

mRNA Protein Name
NM_005683.4 NP_005674.2 G-protein coupled receptor 55
XM_011512176.3 XP_011510478.1 G-protein coupled receptor 55 isoform X1
XM_005246952.5 XP_005247009.1 G-protein coupled receptor 55 isoform X1
XM_011512175.4 XP_011510477.1 G-protein coupled receptor 55 isoform X1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cannabinoid receptor activity IDA
IDA: 通过直接分析推断
19723626 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in bone resorption IDA
IDA: 通过直接分析推断
19805329 GOA
involved in negative regulation of osteoclast differentiation IDA
IDA: 通过直接分析推断
19805329 GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
18757503 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
19805329 GOA
involved in positive regulation of Rho protein signal transduction IDA
IDA: 通过直接分析推断
19805329 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
18757503 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GPR55 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (38 - 288)

  • 0
  • 100
  • 200
  • 300
  • 319 a.a.
蛋白主名 其他名称

G-protein coupled receptor 55

关联疾病

疾病名称 别名
Lennox-Gastaut Syndrome

Epileptic Encephalopathy Lennox-Gastaut Type

Lennox Syndrome

Encephalopathy Of Childhood

Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves

Lgs
Vulvar Syringoma
Cannabis Abuse

Marijuana Abuse
Cannabis Dependence

Marijuana Abuse

Cannabinoid Addiction

Cannabinoid Dependence

Cannabis Addiction
Childhood Electroclinical Syndrome
Hallucinogen Dependence

Hallucinogen Addiction
Dravet Syndrome

Severe Myoclonic Epilepsy Of Infancy

Smei

Severe Myoclonic Epilepsy In Infancy

Epileptic Encephalopathy, Early Infantile, 6

DRVT

Developmental And Epileptic Encephalopathy 6a

Dee6a

Eiee6

Dee6

Developmental And Epileptic Encephalopathy 6

Early Infantile Epileptic Encephalopathy 6

Myoclonic Epilepsy, Severe, Of Infancy

Sme

Severe Myoclonus Epilepsy Of Infancy

Borderline Smei

Smeb

Smeb-M

Smeb-O

Smeb-Sw

Smei-Borderland

Smei-Borderland More Than One Feature

Smei-Borderland-Myoclonic Seizures

Smei-Borderland-Spike Wave

Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures

ICEGTC

Developmental And Epileptic Encephalopathy, 6

Infantile Severe Myoclonic Epilepsy

Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures
Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (19)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10863 Anandamide Activator ≥99.0% 否
HY-16697 CID 16020046 Antagonist 99.87% 否
HY-107541 O-1602 Agonist 99.79% 否
HY-110125 ML-193 Antagonist 99.82% 否
HY-116461 ML-184 Agonist 99.57% 否
HY-116637 Tetrahydromagnolol Antagonist 99.79% 否
HY-122246 ML192 Antagonist / 否
HY-111083 ML191 Antagonist 99.65% 否
HY-W020035 L-α-lysophosphatidylinositol (Soy) (sodium) ≥99.0% 否
HY-125111 PSB-SB-487 Antagonist 99.36% 否
HY-156157 GPR55 agonist 4 Agonist 98.36% 否
HY-10863S Anandamide-d8 Activator 99.90% 否
HY-156107 GPR55 agonist 3 Agonist 99.17% 否
HY-123239 KLS-13019 Antagonist / 否
HY-10863S1 Anandamide-d11 / 否
HY-103336 Tocrifluor 1117 Agonist / 否
HY-114954 CID1792197 Agonist / 否
HY-123302 CID1172084 Agonist / 否
HY-111162 GSK494581A / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta GPR55 VGNC VGNC:104534
Canis familiaris GPR55 VGNC VGNC:41438
Mus musculus GPR55 MGD MGI:2685064
Bos taurus GPR55 VGNC VGNC:29591
Felis catus GPR55 VGNC VGNC:67433
Rattus norvegicus GPR55 RGD RGD:1559828
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