1. Gene
  2. TAOK2 - TAO kinase 2 Gene

TAOK2 - TAO kinase 2 Gene

中文名称:TAO 激酶 2

种属: Homo sapiens

同用名: PSK; PSK1; TAO1; TAO2; MAP3K17; Tao2beta; PSK1-BETA

基因 ID: 9344 | 基因类型: protein coding

关于 TAOK2

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:29,973,868-29,992,261 (from NCBI)

This gene has 6 transcripts (splice variants), 148 orthologues and 35 paralogues. Ubiquitous expression in fat (RPKM 12.5), testis (RPKM 11.6) and 25 other tissues.

功能概要

该基因编码参与许多不同过程的丝氨酸/苏氨酸蛋白激酶,包括细胞信号传导、微管组织和稳定性以及细胞凋亡。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供,2011 年 10 月]

This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and Apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

TAOK2 基因产物(3)

mRNA Protein Name
NM_001252043.2 NP_001238972.1 serine/threonine-protein kinase TAO2 isoform 3
NM_004783.4 NP_004774.1 serine/threonine-protein kinase TAO2 isoform 2
NM_016151.4 NP_057235.2 serine/threonine-protein kinase TAO2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables mitogen-activated protein kinase kinase binding IPI
IPI: 通过物理相互作用推断
11279118 GOA
enables neuropilin binding IPI
IPI: 通过物理相互作用推断
22683681 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
10660600 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
17396146 GOA
involved in actin cytoskeleton organization IDA
IDA: 通过直接分析推断
10660600 GOA
involved in axonogenesis IGI
IGI: 通过遗传相互作用推断
22683681 GOA
involved in focal adhesion assembly IDA
IDA: 通过直接分析推断
10660600 GOA
involved in mitotic G2 DNA damage checkpoint signaling IMP
IMP: 通过突变表型推断
17396146 GOA
involved in positive regulation of JNK cascade IDA
IDA: 通过直接分析推断
10660600 GOA
involved in positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
10660600 GOA
involved in positive regulation of stress-activated MAPK cascade IMP
IMP: 通过突变表型推断
17396146 GOA
involved in regulation of cell shape IDA
IDA: 通过直接分析推断
10660600 GOA
involved in stress-activated MAPK cascade IDA
IDA: 通过直接分析推断
11279118 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
10660600 GOA
part of receptor complex IDA
IDA: 通过直接分析推断
23382219 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TAOK2 蛋白结构

Pkinase

Pkinase: Protein kinase domain (30 - 281)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1235 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase TAO2

PSK-1

TAOK2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TAOK2 Q9UL54 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra TAOK2 Q9UL54 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra TAOK2 Q9UL54 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
Intra TAOK2 Q9UL54 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
Intra TAOK2 Q9UL54 MAPRE3 Homo sapiens Q9UPY8
Y2H Prey Pooling
32296183
Intra TAOK2 Q9UL54 MAPRE3 Homo sapiens Q9UPY8
Y2H Array
32296183
Intra TAOK2 Q9UL54 MAPRE3 Homo sapiens Q9UPY8
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Mus musculus TAOK2 MGD MGI:1915919
Rattus norvegicus TAOK2 RGD RGD:621590
Felis catus TAOK2 VGNC VGNC:107821
Bos taurus TAOK2 VGNC VGNC:35596
Macaca mulatta TAOK2 VGNC VGNC:81592
Canis familiaris TAOK2 VGNC VGNC:47103
Others TAOK2 NCBI