2. Gene
  3. S1pr5 - sphingosine-1-phosphate receptor 5 Gene

S1pr5 - sphingosine-1-phosphate receptor 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：1-磷酸鞘氨醇受体 5

种属: Mus musculus

同用名: Edg8; S1P5; lpB4

基因 ID: 94226 | 基因类型: protein coding

关于 S1pr5

Chromosome 9: 21,154,208-21,159,739 reverse strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 236 orthologues, 18 paralogues and is associated with 5 phenotypes. Biased expression in cerebellum adult (RPKM 1.8), stomach adult (RPKM 9.4) and 11 other tissues.

功能概要

预计该基因编码的蛋白可启动 G 蛋白偶联受体活性。预计参与腺苷酸环化酶激活 G 蛋白偶联受体信号通路和代谢过程的调控。预测作用于 G 蛋白偶联受体信号通路的上游或内部。预计是膜的组成部分。预计在细胞质和质膜中有活性。以多种结构表达，包括中枢神经系统；生殖器结节;肝;感觉器官；和未分段的间充质。与人 S1PR5（1-磷酸鞘氨醇受体 5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including central nervous system; genital tubercle; liver; sensory organ; and unsegmented mesenchyme. Orthologous to human S1PR5 (sphingosine-1-phosphate receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

S1pr5 基因产物(1)

mRNA Protein Name
NM_053190.2 NP_444420.1 sphingosine 1-phosphate receptor 5
基因本体论
  • 细胞组分
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in presynapse IDA
IDA: 通过直接分析推断
35781853 MGI
is active in presynapse IEP
IEP: 通过表达模式推断
35781853 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

S1pr5 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (36 - 317)

7tm_GPCRs

7tm_GPCRs: cd14964 (38 - 62)

7tm_GPCRs

7tm_GPCRs: cd14964 (71 - 92)

7tm_GPCRs

7tm_GPCRs: cd14964 (108 - 130)

7tm_GPCRs

7tm_GPCRs: cd14964 (152 - 168)

7tm_GPCRs

7tm_GPCRs: cd14964 (189 - 212)

7tm_GPCRs

7tm_GPCRs: cd14964 (250 - 272)

7tm_GPCRs

7tm_GPCRs: cd14964 (285 - 310)

  • 0
  • 100
  • 200
  • 300
  • 400 a.a.
蛋白主名 其他名称

sphingosine 1-phosphate receptor 5

S1P receptor 5

S1P receptor Edg-8

endothelial differentiation G-protein-coupled receptor 8

endothelial differentiation, sphingolipid G-protein-coupled receptor, 8

lysophospholipid receptor B4

sphingosine 1-phosphate receptor Edg-8

sphingosine-1-phosphate receptor LPB4

相关产品

Approval
生物活性分子 (5)
目录号 产品名 作用方式
纯度 是否罕见病
HY-12355 Siponimod Agonist 99.95% 否
HY-12288 Ozanimod Agonist 99.88% 是
HY-10569 Ponesimod Agonist 99.81% 是
HY-12288A Ozanimod hydrochloride Modulator 99.19% 是
HY-12355A Siponimod hemifumarate Agonist / 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-17606 Cenerimod Agonist 99.43% Phase 3
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-136578 RP101988 Agonist 98.92% 否
HY-111253 CYM-5478 Agonist 99.90% 否
HY-148198 S1P5 receptor agonist-1 Agonist / 否
HY-148115 S1p receptor agonist 2 Agonist / 否
HY-136576 RP101075 Agonist / 否
HY-136577 RP101442 Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens S1pr5 NCBI NCBI:53637
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