2. Gene
  3. ADAMTS1 - ADAM metallopeptidase with thrombospondin type 1 motif 1 Gene

ADAMTS1 - ADAM metallopeptidase with thrombospondin type 1 motif 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：具有 1 型血小板反应蛋白基序 1 的 ADAM 金属肽酶

种属: Homo sapiens

同用名: C3-C5; METH1

基因 ID: 9510 | 基因类型: protein coding

关于 ADAMTS1

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:26,835,755-26,845,409 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and 25 paralogues. Broad expression in ovary (RPKM 126.2), placenta (RPKM 77.2) and 17 other tissues.

功能概要

该基因编码 ADAMTS (一种具有血小板反应蛋白基序的去整合素和金属蛋白酶) 蛋白家族的成员。该家族的成员共享几个不同的蛋白质模块，包括前肽区域、金属蛋白酶结构域、解整合素样结构域和 1 型血小板反应蛋白 (TS) 基序。这个家族的个别成员在 C 端 TS 基序的数量上有所不同，有些成员具有独特的 C 端结构域。该基因编码的蛋白质含有两个解整合素环和三个 C 端 TS 基序，具有抗血管生成活性。该基因的表达可能与各种炎症过程以及癌症恶病质的发展有关。该基因可能是正常生长、生育以及器官形态和功能所必需的。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of Cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]

ADAMTS1 基因产物(1)

mRNA Protein Name
NM_006988.5 NP_008919.3 A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables metalloendopeptidase activity IDA
IDA: 通过直接分析推断
11278559 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within negative regulation of angiogenesis IDA
IDA: 通过直接分析推断
10438512 GOA
involved in positive regulation of G1/S transition of mitotic cell cycle IGI
IGI: 通过遗传相互作用推断
28890348 GOA
involved in positive regulation of vascular associated smooth muscle cell migration IGI
IGI: 通过遗传相互作用推断
28890348 GOA
involved in positive regulation of vascular associated smooth muscle cell proliferation IGI
IGI: 通过遗传相互作用推断
28890348 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADAMTS1 蛋白结构

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (70 - 166)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (258 - 467)

TSP_1

TSP_1: Thrombospondin type 1 domain (564 - 613)

ADAM_spacer1

ADAM_spacer1: ADAM-TS Spacer 1 (725 - 842)

TSP_1

TSP_1: Thrombospondin type 1 domain (861 - 909)

TSP_1

TSP_1: Thrombospondin type 1 domain (915 - 966)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 967 a.a.
蛋白主名 其他名称

A disintegrin and metalloproteinase with thrombospondin motifs 1

ADAM-TS 1

ADAMTS1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ADAMTS1 Q9UHI8 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra ADAMTS1 Q9UHI8 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra ADAMTS1 Q9UHI8 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Cross ADAMTS1 Q9UHI8 ns8_sars2 SARS-CoV-2 P0DTC8
Y2H Array
36217030
Intra ADAMTS1 Q9UHI8 PSMD9 Homo sapiens O00233
Validated Y2H
32814053
Intra ADAMTS1 Q9UHI8 PSMD9 Homo sapiens O00233
Y2H Array
32814053
Intra ADAMTS1 Q9UHI8 PSMD9 Homo sapiens O00233
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos
Ureteral Obstruction
Chondrosarcoma

Cartilaginous Cancer

Chondrosarcoma Of Bone

Primary Chondrosarcoma Of The Bone

CHDSA
Cardiomyopathy, Dilated, 1l

Dilated Cardiomyopathy 1l

CMD1L

Cardiomyopathy, Dilated 1l

Cardiomyopathy, Dilated, Type 1l
Keratitis, Hereditary

Keratitis

Autosomal Dominant Keratitis

Hereditary Keratitis

Dominantly Inherited Keratitis

Keratitis Hereditary

KERH
Marfan Syndrome

MFS

Mfs1

Marfan'S Syndrome

Marfan Syndrome Type 1

Marfan Syndrome, Type I

Mass Phenotype

Contractural Arachnodactyly

Mass Syndrome

Octd

Overlap Connective Tissue Disease

Marfanoid Hypermobility Syndrome

Marfan Disease
Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm

Annuloaortic Ectasia

Familial Thoracic Aortic Aneurysm And Aortic Dissection

Familial Aortic Dissection

Familial Taad

Familial Thoracic Aortic Aneurysm

Congenital Aneurysm Of Ascending Aorta

Familial Aortic Aneurysm

Familial Thoracic Aortic Aneurysm And Dissection

Aortic Aneurysm, Thoracic

AAT1

Faa1

Aortic Dissection, Familial

Aortic Aneurysm, Familial Thoracic

Aneurysm, Thoracic Aortic

Faa

Ftaad

Taa

Taad

Cystic Medial Necrosis Of Aorta

Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection

Aortic Aneurysm Thoracic

Familial Aortic Aneurysms

Aneurysm, Aortic, Thoracic, Familial, Type 1

Aneurysm Of Thoracic Aorta

Intrathoracic Aneurysm

Thoracic Aorta Aneurysm

Thoracic Aortic Aneurysm Without Rupture

Thoracic Aneurysm

Thorax Arterial Aneurysm

Thoracic Artery Aneurysm

Thoracic Arterial Aneurysm

Thorax Aneurysm

Thorax Aortic Aneurysm

Dissection Of Thoracic Aorta
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00291 ADAMTS1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ADAMTS1 RGD RGD:621241
Felis catus ADAMTS1 VGNC VGNC:59587
Canis familiaris ADAMTS1 VGNC VGNC:37590
Macaca mulatta ADAMTS1 VGNC VGNC:80327
Mus musculus ADAMTS1 MGD MGI:109249
Bos taurus ADAMTS1 VGNC VGNC:25614
Others ADAMTS1 NCBI
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