2. Gene
  3. PRDX6 - peroxiredoxin 6 Gene

PRDX6 - peroxiredoxin 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：过氧化物酶 6

种属: Homo sapiens

同用名: PRX; p29; AOP2; 1-Cys; NSGPx; aiPLA2; LPCAT-5; HEL-S-128m

基因 ID: 9588 | 基因类型: protein coding

关于 PRDX6

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:173,477,335-173,488,815 (from NCBI)

This gene has 3 transcripts (splice variants), 184 orthologues and 4 paralogues. Ubiquitous expression in fat (RPKM 236.1), liver (RPKM 127.7) and 25 other tissues.

功能概要

由该基因编码的蛋白质是硫醇特异性抗氧化蛋白质家族的成员。这种蛋白质是一种双功能酶，具有两个不同的活性位点。它参与细胞的氧化还原调节；它可以减少 H (2) O (2) 和短链有机物、脂肪酸和磷脂氢过氧化物。它可能在调节磷脂周转以及防止氧化损伤方面发挥作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional Enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]

PRDX6 基因产物(1)

mRNA Protein Name
NM_004905.3 NP_004896.1 peroxiredoxin-6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-acylglycerophosphocholine O-acyltransferase activity IDA
IDA: 通过直接分析推断
26830860 GOA
enables calcium-independent phospholipase A2 activity IMP
IMP: 通过突变表型推断
10893423 GOA
enables glutathione peroxidase activity IMP
IMP: 通过突变表型推断
10893423 GOA
enables identical protein binding IMP
IMP: 通过突变表型推断
9587003 GOA
enables phospholipase A2 activity IDA
IDA: 通过直接分析推断
26830860 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16186110 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
19725078 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular oxidant detoxification IMP
IMP: 通过突变表型推断
10893423 GOA
involved in glycerophospholipid catabolic process IMP
IMP: 通过突变表型推断
10893423 GOA
involved in positive regulation of mRNA splicing, via spliceosome IGI
IGI: 通过遗传相互作用推断
16186110 GOA
involved in response to oxidative stress IMP
IMP: 通过突变表型推断
10893423 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16186110 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16186110 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
16186110 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRDX6 蛋白结构

AhpC-TSA

AhpC-TSA: AhpC/TSA family (7 - 144)

1-cysPrx_C

1-cysPrx_C: C-terminal domain of 1-Cys peroxiredoxin (166 - 205)

  • 0
  • 100
  • 200
  • 224 a.a.
蛋白主名 其他名称

peroxiredoxin-6

1-Cys PRX

PRDX6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PRDX6 P30041 ARFGAP3 Homo sapiens Q9NP61
Y2H Array
32814053
种属内
PRDX6 P30041 ARFGAP3 Homo sapiens Q9NP61
Y2H Pooling
32814053
种属内
PRDX6 P30041 ARFGAP3 Homo sapiens Q9NP61
Validated Y2H
32814053
种属内
PRDX6 P30041 PCNA Homo sapiens P12004
Far-WB
20849852
种属内
PRDX6 P30041 PCNA Homo sapiens P12004
BiFC
26030842
种属内
PRDX6 P30041 PSMD8 Homo sapiens P48556
Y2H Prey Pooling
32296183
种属内
PRDX6 P30041 PSMD8 Homo sapiens P48556
Validated Y2H
32296183
种属内
PRDX6 P30041 PSMD8 Homo sapiens P48556
Y2H Array
32296183
种属内
PRDX6 P30041 TERF1 Homo sapiens P54274
Pull Down
21044950
种属间
PRDX6 P30041 P29991-PRO_0000308465 Dengue virus type 2 P29991-PRO_0000308465
Y2H
21911577
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PRDX6 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71145 PRDX6 Protein, Human (His) P30041 (M1-P224) ≥95%

PRDX6 抗体

目录号 产品名 应用 反应物种
HY-P83409 Peroxiredoxin 6 Antibody (YA3154) WB, IP Human

关联疾病

疾病名称 别名
Gnathomiasis

Gnathostomiasis

Infectious Disease By Gnathostoma

Gnathostomosis

Wandering Swelling
Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy

Fuchs Endothelial Dystrophy

Fuchs Dystrophy

Fced

Fuchs' Corneal Dystrophy

Fuchs' Endothelial Corneal Dystrophy

Fuchs Atrophy

Fuchs Corneal Dystrophy

Endoepithelial Corneal Dystrophy

Fecd

Late Hereditary Endothelial Dystrophy

Corneal Dystrophy, Fuchs Endothelial

Dystrophy, Corneal, Fuchs Endothelial

Corneal Dystrophy, Fuchs' Endothelial, 1
Diabetic Cataract

Cataract - Diabetic
Small Intestine Leiomyosarcoma

Leiomyosarcoma Of The Small Bowel

Smooth Muscle Connective Tissue Tumor

Leiomyosarcoma Of Small Intestine
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-115062 MJ33 lithium salt Inhibitor ≥99.0% 否
HY-129944A MJ33-OH lithium Inhibitor ≥90.0% 否
HY-129944 MJ33-OH Inhibitor / 否
HY-RS11079 PRDX6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PRDX6 VGNC VGNC:76267
Felis catus PRDX6 VGNC VGNC:107925
Bos taurus PRDX6 VGNC VGNC:33304
Mus musculus PRDX6 MGD MGI:894320
Canis familiaris PRDX6 VGNC VGNC:44953
Rattus norvegicus PRDX6 RGD RGD:71005
Others PRDX6 NCBI
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