1. Gene
  2. SNX17 - sorting nexin 17 Gene

SNX17 - sorting nexin 17 Gene

中文名称:排序 nexin 17

种属: Homo sapiens

基因 ID: 9784 | 基因类型: protein coding

关于 SNX17

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,370,616-27,377,535 (from NCBI)

This gene has 10 transcripts (splice variants), 216 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 29.0), lymph node (RPKM 26.3) and 25 other tissues.

功能概要

该基因编码分选连接蛋白家族的一个成员。该家族的成员包含一个 phox (PX) 结构域,它是一个磷酸肌醇结合结构域,并参与细胞内运输。这种蛋白质不像某些家族成员那样包含卷曲螺旋区域,但包含 B41 结构域。该蛋白与 P-选择素的细胞质结构域相互作用,并可能在 P-选择素的细胞内运输中发挥作用。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供,2012 年 5 月]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]

SNX17 基因产物(4)

mRNA Protein Name
NM_001267059.2 NP_001253988.1 sorting nexin-17 isoform 2
NM_001267060.2 NP_001253989.1 sorting nexin-17 isoform 3
NM_001267061.2 NP_001253990.1 sorting nexin-17 isoform 4
NM_014748.4 NP_055563.1 sorting nexin-17 isoform 1

SNX17 蛋白结构

PX

PX: PX domain (11 - 103)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 470 a.a.
蛋白主名 其他名称

sorting nexin-17

SNX17 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SNX17 Q15036 HOXC8 Homo sapiens P31273
Y2H Array
32296183
种属内
SNX17 Q15036 HOXC8 Homo sapiens P31273
Y2H Prey Pooling
32296183
种属内
SNX17 Q15036 RNF128 Homo sapiens Q8TEB7
Y2H Array
32296183
种属内
SNX17 Q15036 RNF128 Homo sapiens Q8TEB7
Y2H Prey Pooling
32296183
种属内
SNX17 Q15036 RNF128 Homo sapiens Q8TEB7
Validated Y2H
32296183
种属内
SNX17 Q15036 NCK1 Homo sapiens P16333
Peptide Array
17474147
种属内
SNX17 Q15036 RABAC1 Homo sapiens Q9UI14
Y2H Prey Pooling
32296183
种属内
SNX17 Q15036 RABAC1 Homo sapiens Q9UI14
Validated Y2H
32296183
种属内
SNX17 Q15036 RABAC1 Homo sapiens Q9UI14
Y2H Array
32296183
种属内
SNX17 Q15036 PLCG1 Homo sapiens P19174
Peptide Array
17474147
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypercholesterolemia, Familial, 4

Hypercholesterolemia, Autosomal Recessive

Arh

FHCL4

Autosomal Recessive Hypercholesterolemia

Arh1

Arh2

Autosomal Recessive Hypercholesterolemia 1

Autosomal Recessive Hypercholesterolemia 2

Fhcb1

Fhcb2

Hypercholesterolemia, Autosomal Recessive, 1, Formerly

Arh1, Formerly

Fhcb1, Formerly

Hypercholesterolemia, Autosomal Recessive, 2, Formerly

Arh2, Formerly

Fhcb2, Formerly

Familial Autosomal Recessive Hypercholesterolemia

Hypercholesterolemia, Familial, Autosomal Recessive

Hypercholesterolemia, Familial, Type 4

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SNX17 RGD RGD:1306424
Mus musculus SNX17 MGD MGI:2387801
Macaca mulatta SNX17 VGNC VGNC:77709
Bos taurus SNX17 VGNC VGNC:35097
Canis familiaris SNX17 VGNC VGNC:46626
Felis catus SNX17 VGNC VGNC:65547