1. Gene
  2. ACYP2 - acylphosphatase 2 Gene

ACYP2 - acylphosphatase 2 Gene

中文名称:酰基磷酸酶 2

种属: Homo sapiens

同用名: ACYM; ACYP

基因 ID: 98 | 基因类型: protein coding

关于 ACYP2

Cytogenetic location: 2p16.2 Genomic coordinates (GRCh38): 2:53,971,113-54,305,300 (from NCBI)

This gene has 9 transcripts (splice variants), 238 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 3.1), heart (RPKM 2.8) and 25 other tissues.

功能概要

酰基磷酸酶可以水解不同膜泵的磷酸酶中间体,特别是来自骨骼肌肌质网的 Ca2+/Mg2+-ATP 酶。已分离出两种同工酶,根据它们的组织定位,称为肌肉酰基磷酸酶和红细胞酰基磷酸酶。该基因编码肌肉型亚型 (MT) 。 MT 亚型的增加与肌肉分化有关。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供,2016 年 2 月]

Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

ACYP2 基因产物(6)

mRNA Protein Name
NM_001320586.2 NP_001307515.1 acylphosphatase-2 isoform 1
NM_001320587.2 NP_001307516.1 acylphosphatase-2 isoform 2
NM_001320588.2 NP_001307517.1 acylphosphatase-2 isoform 4
NM_001320589.2 NP_001307518.1 acylphosphatase-2 isoform 5
NM_001320590.2 NP_001307519.1 acylphosphatase-2 isoform 6
NM_138448.4 NP_612457.1 acylphosphatase-2 isoform 3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
12374855 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ACYP2 蛋白结构

Acylphosphatase

Acylphosphatase: Acylphosphatase (8 - 98)

  • 0
  • 99 a.a.
蛋白主名 其他名称

acylphosphatase-2

acylphosphatase 2, muscle type

ACYP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ACYP2 P14621 GFPT2 Homo sapiens O94808 33961781
种属内
ACYP2 P14621 ACYP2 Homo sapiens P14621 12374855
种属内
ACYP2 P14621 SULT2B1 Homo sapiens O00204 25416956
种属内
ACYP2 P14621 ACYP2 Homo sapiens P14621 16084386
种属内
ACYP2 P14621 ACYP2 Homo sapiens P14621
DLS
16084386
种属内
ACYP2 P14621 CARM1 Homo sapiens Q86X55 33961781
种属内
ACYP2 P14621 OGA Homo sapiens O60502 33961781
种属内
ACYP2 P14621 BCS1L Homo sapiens Q9Y276 33961781
种属内
ACYP2 P14621 SULT2B1 Homo sapiens O00204 25416956
种属内
ACYP2 P14621 CREBZF Homo sapiens Q9NS37 25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ACYP2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7459 Acylphosphatase-2/ACYP2 Protein, Human (GST) P14621 (S2-Y99) ≥95%

直系同源

种属 基因名 来源 基因 ID
Felis catus ACYP2 VGNC VGNC:98504
Mus musculus ACYP2 MGD MGI:1922822
Rattus norvegicus ACYP2 RGD RGD:1595836
Canis familiaris ACYP2 VGNC VGNC:37567
Macaca mulatta ACYP2 VGNC VGNC:82096
Bos taurus ACYP2 VGNC VGNC:25599
Others ACYP2 NCBI