2. Gene
  3. MELK - maternal embryonic leucine zipper kinase Gene

MELK - maternal embryonic leucine zipper kinase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：母体胚胎亮氨酸拉链激酶

种属: Homo sapiens

同用名: HPK38

基因 ID: 9833 | 基因类型: protein coding

关于 MELK

Cytogenetic location: 9p13.2 Genomic coordinates (GRCh38): 9:36,572,895-36,677,682 (from NCBI)

This gene has 14 transcripts (splice variants), 217 orthologues and 17 paralogues. Broad expression in testis (RPKM 5.2), lymph node (RPKM 4.4) and 14 other tissues.

功能概要

启用钙离子结合活性；非跨膜蛋白酪氨酸激酶活性；和蛋白丝氨酸/苏氨酸激酶活性。参与细胞凋亡过程；细胞群增殖；和蛋白质自身磷酸化。位于细胞皮层和质膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Involved in apoptotic process; cell population proliferation; and protein autophosphorylation. Located in cell cortex and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

MELK 基因产物(53)

mRNA Protein Name
NM_001256688.2 NP_001243617.1 maternal embryonic leucine zipper kinase isoform 4
XM_047424189.1 XP_047280145.1 maternal embryonic leucine zipper kinase isoform X12
NR_046337.2
XM_047424204.1 XP_047280160.1 maternal embryonic leucine zipper kinase isoform X17
XM_047424206.1 XP_047280162.1 maternal embryonic leucine zipper kinase isoform X19
XM_011518076.3 XP_011516378.1 maternal embryonic leucine zipper kinase isoform X1
XM_011518082.3 XP_011516384.1 maternal embryonic leucine zipper kinase isoform X3
NM_001256689.2 NP_001243618.1 maternal embryonic leucine zipper kinase isoform 5
XM_047424178.1 XP_047280134.1 maternal embryonic leucine zipper kinase isoform X7
XM_047424191.1 XP_047280147.1 maternal embryonic leucine zipper kinase isoform X12
XM_047424172.1 XP_047280128.1 maternal embryonic leucine zipper kinase isoform X5
NM_014791.4 NP_055606.1 maternal embryonic leucine zipper kinase isoform 1
XM_047424174.1 XP_047280130.1 maternal embryonic leucine zipper kinase isoform X6
XM_047424188.1 XP_047280144.1 maternal embryonic leucine zipper kinase isoform X10
XM_047424166.1 XP_047280122.1 maternal embryonic leucine zipper kinase isoform X1
NM_001256690.2 NP_001243619.1 maternal embryonic leucine zipper kinase isoform 6
XM_047424197.1 XP_047280153.1 maternal embryonic leucine zipper kinase isoform X14
XM_047424182.1 XP_047280138.1 maternal embryonic leucine zipper kinase isoform X8
XM_047424171.1 XP_047280127.1 maternal embryonic leucine zipper kinase isoform X4
NM_001256693.2 NP_001243622.1 maternal embryonic leucine zipper kinase isoform 9
NM_001256691.2 NP_001243620.1 maternal embryonic leucine zipper kinase isoform 7
XM_047424185.1 XP_047280141.1 maternal embryonic leucine zipper kinase isoform X9
XM_047424183.1 XP_047280139.1 maternal embryonic leucine zipper kinase isoform X8
XM_047424202.1 XP_047280158.1 maternal embryonic leucine zipper kinase isoform X17
NM_001256692.2 NP_001243621.1 maternal embryonic leucine zipper kinase isoform 8
XM_047424186.1 XP_047280142.1 maternal embryonic leucine zipper kinase isoform X9
XM_047424198.1 XP_047280154.1 maternal embryonic leucine zipper kinase isoform X15
XM_047424180.1 XP_047280136.1 maternal embryonic leucine zipper kinase isoform X7
XM_047424196.1 XP_047280152.1 maternal embryonic leucine zipper kinase isoform X14
XM_047424177.1 XP_047280133.1 maternal embryonic leucine zipper kinase isoform X6
XM_047424176.1 XP_047280132.1 maternal embryonic leucine zipper kinase isoform X6
XM_047424179.1 XP_047280135.1 maternal embryonic leucine zipper kinase isoform X7
NM_001256685.2 NP_001243614.1 maternal embryonic leucine zipper kinase isoform 2
XM_047424170.1 XP_047280126.1 maternal embryonic leucine zipper kinase isoform X4
XM_047424193.1 XP_047280149.1 maternal embryonic leucine zipper kinase isoform X13
XM_047424200.1 XP_047280156.1 maternal embryonic leucine zipper kinase isoform X16
XM_047424195.1 XP_047280151.1 maternal embryonic leucine zipper kinase isoform X13
XM_011518077.2 XP_011516379.1 maternal embryonic leucine zipper kinase isoform X1
XM_011518081.3 XP_011516383.1 maternal embryonic leucine zipper kinase isoform X3
NM_001256687.2 NP_001243616.1 maternal embryonic leucine zipper kinase isoform 3
XM_047424173.1 XP_047280129.1 maternal embryonic leucine zipper kinase isoform X5
XM_047424169.1 XP_047280125.1 maternal embryonic leucine zipper kinase isoform X2
XM_011518085.2 XP_011516387.1 maternal embryonic leucine zipper kinase isoform X11
XM_047424184.1 XP_047280140.1 maternal embryonic leucine zipper kinase isoform X9
XM_047424192.1 XP_047280148.1 maternal embryonic leucine zipper kinase isoform X12
XM_047424194.1 XP_047280150.1 maternal embryonic leucine zipper kinase isoform X13
XM_047424199.1 XP_047280155.1 maternal embryonic leucine zipper kinase isoform X16
XM_047424205.1 XP_047280161.1 maternal embryonic leucine zipper kinase isoform X18
XM_047424181.1 XP_047280137.1 maternal embryonic leucine zipper kinase isoform X8
XM_047424168.1 XP_047280124.1 maternal embryonic leucine zipper kinase isoform X2
XM_047424187.1 XP_047280143.1 maternal embryonic leucine zipper kinase isoform X10
XM_047424203.1 XP_047280159.1 maternal embryonic leucine zipper kinase isoform X17
XM_011518080.1 XP_011516382.1 maternal embryonic leucine zipper kinase isoform X2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
16216881 GOA
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
16216881 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12400006 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
12400006 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in apoptotic process IDA
IDA: 通过直接分析推断
17280616 GOA
involved in cell population proliferation IDA
IDA: 通过直接分析推断
17280616 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
16216881 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell cortex IDA
IDA: 通过直接分析推断
16159311 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
21145462 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MELK 蛋白结构

Pkinase

Pkinase: Protein kinase domain (11 - 263)

KA1

KA1: Kinase associated domain 1 (606 - 651)

  • 0
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  • 500
  • 600
  • 651 a.a.
蛋白主名 其他名称

maternal embryonic leucine zipper kinase

pEg3 kinase

protein kinase Eg3

protein kinase PK38

tyrosine-protein kinase MELK

MELK 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MELK Q14680 BCL2L14 Homo sapiens Q9BZR8
Pull Down
17280616
种属间: 跨种属相互作用 种属内: 同种属相互作用

MELK 抗体

目录号 产品名 应用 反应物种
HY-P81678 MELK Antibody (YA1423) WB Human

关联疾病

疾病名称 别名
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-15512A OTSSP167 hydrochloride Inhibitor 99.84% Phase 2
HY-15512 OTSSP167 Inhibitor 99.70% Phase 2
Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100368A MELK-8a hydrochloride Inhibitor 99.31% 否
HY-101515 MELK-IN-1 Inhibitor 98.67% 否
HY-12420 JNJ-47117096 hydrochloride Inhibitor 99.68% 否
HY-122665 HTH-01-091 Inhibitor 98.64% 否
HY-100368 MELK-8a Inhibitor 98.32% 否
HY-122665A HTH-01-091 TFA Inhibitor 99.48% 否
HY-155748 Antitumor agent-116 Inhibitor / 否
HY-12420A JNJ-47117096 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MELK RGD RGD:1308974
Canis familiaris MELK VGNC VGNC:51744
Bos taurus MELK VGNC VGNC:50031
Mus musculus MELK MGD MGI:106924
Macaca mulatta MELK VGNC VGNC:74521
Others MELK NCBI
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