PSMD6 - proteasome 26S subunit, non-ATPase 6 Gene

中文名称：蛋白酶体 26S 亚基，非 ATPase 6

种属: Homo sapiens

同用名: S10; Rpn7; p42A; p44S10; SGA-113M

基因 ID: 9861 | 基因类型: protein coding

关于 PSMD6

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:64,010,551-64,024,007 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 47.2), bone marrow (RPKM 29.6) and 25 other tissues.

功能概要

该基因编码蛋白酶亚基 S10 家族的一个成员。编码的蛋白质是 26S 蛋白酶体的一个亚基，它与 DNA 损伤灶共定位，并参与泛素化蛋白质的 ATP 依赖性降解。可变剪接导致多个转录变体[RefSeq 提供，2012 年 11 月]

This gene encodes a member of the protease subunit S10 family. The encoded protein is a subunit of the 26S Proteasome which colocalizes with DNA damage foci and is involved in the ATP-dependent degradation of ubiquinated proteins. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]

PSMD6 基因产物(4)

mRNA	Protein	Name
NM_001271779.2	NP_001258708.1	26S proteasome non-ATPase regulatory subunit 6 isoform 1
NM_001271780.2	NP_001258709.1	26S proteasome non-ATPase regulatory subunit 6 isoform 3
NM_001271781.2	NP_001258710.1	26S proteasome non-ATPase regulatory subunit 6 isoform 4
NM_014814.3	NP_055629.1	26S proteasome non-ATPase regulatory subunit 6 isoform 2

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16990800	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of proteasome complex	IDA IDA: 通过直接分析推断	17323924	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PSMD6 蛋白结构

RPN7

PCI

0
100
200
300
389 a.a.

蛋白主名

其他名称

26S proteasome non-ATPase regulatory subunit 6

breast cancer-associated protein SGA-113M

PSMD6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PSMD6	Q15008	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
种属内	PSMD6	Q15008	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25416956
种属内	PSMD6	Q15008	CMTM7	Homo sapiens	Q96FZ5	Y2H Prey Pooling	32296183
种属内	PSMD6	Q15008	CMTM7	Homo sapiens	Q96FZ5	Y2H Array	32296183
种属内	PSMD6	Q15008	CMTM7	Homo sapiens	Q96FZ5	Validated Y2H	32296183
种属内	PSMD6	Q15008	PSMD4	Homo sapiens	P55036	Anti Bait CoIP	17353931
种属内	PSMD6	Q15008	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
种属内	PSMD6	Q15008	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
种属内	PSMD6	Q15008	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11327	PSMD6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	PSMD6	VGNC	VGNC:69126
Rattus norvegicus	PSMD6	RGD	RGD:735127
Mus musculus	PSMD6	MGD	MGI:1913663
Canis familiaris	PSMD6	VGNC	VGNC:54345
Bos taurus	PSMD6	VGNC	VGNC:33470
Macaca mulatta	PSMD6	VGNC	VGNC:76454

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PSMD6 - proteasome 26S subunit, non-ATPase 6 Gene

关于 PSMD6

功能概要

PSMD6 基因产物(4)

PSMD6 蛋白结构

PSMD6 蛋白互作信息

关联疾病

直系同源

热门区域

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PSMD6 - proteasome 26S subunit, non-ATPase 6 Gene

关于 PSMD6

功能概要

PSMD6 基因产物(4)

PSMD6 蛋白结构

PSMD6 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z