2. Gene
  3. TOMM70 - translocase of outer mitochondrial membrane 70 Gene

TOMM70 - translocase of outer mitochondrial membrane 70 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：线粒体外膜转位酶 70

种属: Homo sapiens

同用名: Tom70; TOMM70A

基因 ID: 9868 | 基因类型: protein coding

关于 TOMM70

Cytogenetic location: 3q12.2 Genomic coordinates (GRCh38): 3:100,363,431-100,401,089 (from NCBI)

This gene has 3 transcripts (splice variants), 203 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 23.1), thyroid (RPKM 20.6) and 25 other tissues.

功能概要

该基因编码线粒体外膜的输入受体，它是外膜复合体转位酶的一部分。该蛋白参与线粒体前体蛋白的输入。该蛋白与 SARS-CoV 和 SARS-Cov-2 ORF9b 蛋白相互作用。[RefSeq 提供，2021 年 12 月]

This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. The protein interacts with the SARS-CoV and SARS-Cov-2 ORF9b proteins. [provided by RefSeq, Dec 2021]

TOMM70 基因产物(1)

mRNA Protein Name
NM_014820.5 NP_055635.3 mitochondrial import receptor subunit TOM70
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular adaptor activity IDA
IDA: 通过直接分析推断
20628368 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12526792 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of innate immune response IDA
IDA: 通过直接分析推断
20628368 GOA
involved in cellular response to virus IDA
IDA: 通过直接分析推断
25609812 GOA
involved in positive regulation of defense response to virus by host IDA
IDA: 通过直接分析推断
20628368 GOA
involved in positive regulation of interferon-beta production IDA
IDA: 通过直接分析推断
20628368 GOA
involved in regulation of apoptotic process IDA
IDA: 通过直接分析推断
25609812 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in mitochondrial membrane IDA
IDA: 通过直接分析推断
20628368 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
20531390 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TOMM70 蛋白结构

TPR_11

TPR_11: TPR repeat (113 - 184)

TPR_11

TPR_11: TPR repeat (366 - 432)

TPR_11

TPR_11: TPR repeat (477 - 541)

TPR_8

TPR_8: Tetratricopeptide repeat (548 - 576)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 608 a.a.
蛋白主名 其他名称

mitochondrial import receptor subunit TOM70

mitochondrial precursor proteins import receptor

关联疾病

疾病名称 别名
Myopathy, Centronuclear, 1

Autosomal Dominant Centronuclear Myopathy

CNM1

Centronuclear Myopathy 1

Ad-Cnm

Myopathy, Centronuclear, Autosomal Dominant

Myotubular Myopathy, Autosomal Dominant

Centronuclear Myopathy, Autosomal, Modifier Of

Autosomal Dominant Myotubular Myopathy

Dnm2-Related Centronuclear Myopathy

Centronuclear Myopathy Autosomal Dominant

Myopathies, Structural, Congenital

Myopathy, Centronuclear, Type 1
Microcephaly 7, Primary, Autosomal Recessive

MCPH7

Primary Autosomal Recessive Microcephaly 7

Microcephaly, Primary Autosomal Recessive, 7
Spastic Ataxia 5
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14887 TOMM70 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TOMM70 VGNC VGNC:78618
Canis familiaris TOMM70 VGNC VGNC:49630
Felis catus TOMM70 VGNC VGNC:66446
Rattus norvegicus TOMM70 RGD RGD:1303049
Mus musculus TOMM70 MGD MGI:106295
Bos taurus TOMM70 VGNC VGNC:49582
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