2. Gene
  3. SRGAP3 - SLIT-ROBO Rho GTPase activating protein 3 Gene

SRGAP3 - SLIT-ROBO Rho GTPase activating protein 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SLIT-ROBO Rho GTPase 激活蛋白 3

种属: Homo sapiens

同用名: WRP; MEGAP; SRGAP2; ARHGAP14

基因 ID: 9901 | 基因类型: protein coding

关于 SRGAP3

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:8,980,591-9,363,027 (from NCBI)

This gene has 12 transcripts (splice variants), 262 orthologues, 5 paralogues and is associated with 90 phenotypes. Broad expression in brain (RPKM 6.5), urinary bladder (RPKM 1.5) and 16 other tissues.

功能概要

预测启用 GTPase 激活剂活动。预计参与细胞迁移的负调控。预测位于胞质溶胶中。预计在细胞质中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of cell migration. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SRGAP3 基因产物(2)

mRNA Protein Name
NM_001033117.3 NP_001028289.1 SLIT-ROBO Rho GTPase-activating protein 3 isoform b
NM_014850.4 NP_055665.1 SLIT-ROBO Rho GTPase-activating protein 3 isoform a
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17500595 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in postsynapse IDA
IDA: 通过直接分析推断
30123108 GOA
is active in postsynapse IMP
IMP: 通过突变表型推断
30123108 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SRGAP3 蛋白结构

FCH

FCH: Fes/CIP4, and EFC/F-BAR homology domain (23 - 117)

RhoGAP

RhoGAP: RhoGAP domain (520 - 669)

SH3_1

SH3_1: SH3 domain (750 - 795)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1099 a.a.
蛋白主名 其他名称

SLIT-ROBO Rho GTPase-activating protein 3

SLIT-ROBO Rho GTPase activating protein 2

SRGAP3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SRGAP3 O43295 GRB2 Homo sapiens P62993
Anti Tag CoIP
25819436
种属内
SRGAP3 O43295 GRB2 Homo sapiens P62993
ITC
25819436
种属内
SRGAP3 O43295 HTT Homo sapiens P42858
Y2H
17500595
种属间
SRGAP3 O43295 Sh3gl2 Rattus norvegicus O35179
ITC
25819436
种属间
SRGAP3 O43295 Sh3gl2 Rattus norvegicus O35179
Pull Down
25819436
种属间
SRGAP3 O43295 Sh3gl1 Rattus norvegicus O35964
Pull Down
25819436
种属间
SRGAP3 O43295 Sh3gl1 Rattus norvegicus O35964
ITC
25819436
种属间
SRGAP3 O43295 Amph Rattus norvegicus O08838
Pull Down
25819436
种属间
SRGAP3 O43295 Amph Rattus norvegicus O08838
ITC
25819436
种属间
SRGAP3 O43295 Amph Rattus norvegicus O08838
Anti Tag CoIP
25819436
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pilomyxoid Astrocytoma
Chromosome 3pter-P25 Deletion Syndrome

3p- Syndrome

3p Deletion Syndrome

Distal Monosomy 3p

Chromosome 3, Monosomy 3p

3p Partial Monosomy Syndrome

Chromosome 3, Deletion 3p

Chromosome 3p Deletion Syndrome

Del Syndrome

Deletion 3p

Monosomy 3p

Partial Monosomy 3p

Distal 3p Deletion

Monosomy 3pter

Telomeric Monosomy 3p

Chromosome Deletion Syndrome 3pter-P25
Lissencephaly 5

LIS5

Cobblestone Lissencephaly Without Muscular Or Ocular Involvement

Cobblestone Lissencephaly Without Muscular Or Eye Involvement

Lissencephaly Type 2 Without Muscular Or Eye Involvement

Lissencephaly Type 2 Without Muscular Or Ocular Involvement

Lissencephaly, Type 5
Avoidant Personality Disorder

Anxious Personality Disorder

Personality Disorders
Retinitis Pigmentosa 23

RP23

Retinitis Pigmentosa-23

Retinitis Pigmentosa, Type 23

Rp23 Gene
Fibrillary Astrocytoma

Fibrillary Astrocytic Tumors

Diffuse Astrocytoma

Gemistocytic Astrocytoma

Protoplasmic Astrocytoma
Childhood Astrocytic Tumor

Juvenile Astrocytoma

Pediatric Astrocytoma
Pilocytic Astrocytoma

Juvenile Pilocytic Astrocytoma

Grade I Astrocytic Tumor

Piloid Astrocytoma
Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression

Early Infantile Epileptic Encephalopathy With Suppression Bursts

Eiee

Early Infantile Epileptic Encephalopathy With Suppression-Bursts

Ohtahara Syndrome

Encephalopathy, Epileptic, Early Infantile
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13765 SRGAP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SRGAP3 VGNC VGNC:46802
Macaca mulatta SRGAP3 VGNC VGNC:77968
Bos taurus SRGAP3 VGNC VGNC:35279
Rattus norvegicus SRGAP3 RGD RGD:1563152
Felis catus SRGAP3 VGNC VGNC:65680
Mus musculus SRGAP3 MGD MGI:2152938
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