2. Gene
  3. Sh3gl2 - SH3 domain containing GRB2 like 2, endophilin A1 Gene

Sh3gl2 - SH3 domain containing GRB2 like 2, endophilin A1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Sh3p4; Sh3d2a

基因 ID: 116743 | 基因类型: protein coding

关于 Sh3gl2

功能概要

Enables several functions, including identical protein binding activity; protein C-terminus binding activity; and protein kinase binding activity. Involved in several processes, including lipid tube assembly; positive regulation of membrane tubulation; and vesicle scission. Located in several cellular components, including basal dendrite; neuronal cell body; and perinuclear region of cytoplasm. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and synaptic vesicle membrane. Biomarker of visual epilepsy. Orthologous to human SH3GL2 (SH3 domain containing GRB2 like 2, endophilin A1). [provided by Alliance of Genome Resources, Apr 2022]

Sh3gl2 基因产物(1)

mRNA Protein Name
NM_053935.1 NP_446387.1 endophilin-A1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
24568626 RGD
enables lipid binding IDA
IDA: 通过直接分析推断
11604418 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9238017 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
11384986 RGD
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
22961472 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in lipid tube assembly IDA
IDA: 通过直接分析推断
20484046 RGD
involved in membrane bending IMP
IMP: 通过突变表型推断
16763559 RGD
involved in membrane tubulation IDA
IDA: 通过直接分析推断
20484046 RGD
involved in membrane tubulation IMP
IMP: 通过突变表型推断
11604418 RGD
involved in positive regulation of membrane tubulation IMP
IMP: 通过突变表型推断
24778241 RGD
involved in regulation of clathrin-dependent endocytosis IMP
IMP: 通过突变表型推断
15066995 RGD
involved in synaptic vesicle endocytosis IDA
IDA: 通过直接分析推断
22099461 RGD
involved in synaptic vesicle endocytosis IMP
IMP: 通过突变表型推断
22099461 RGD
involved in vesicle scission IDA
IDA: 通过直接分析推断
11604418 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
11518713 RGD
located in basal dendrite IDA
IDA: 通过直接分析推断
14751282 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
17088211 RGD
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: 通过直接分析推断
11518713 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
14751282 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
14751282 RGD
located in presynapse IDA
IDA: 通过直接分析推断
11518713 RGD
is active in synapse IDA
IDA: 通过直接分析推断
11518713 RGD
is active in synaptic vesicle membrane IDA
IDA: 通过直接分析推断
17088211 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

endophilin-A1

SH3 domain protein 2A

SH3 domain-containing GRB2-like 2

SH3 domain-containing GRB2-like protein 2

SH3-domain GRB2-like 2

endophilin-1

Sh3gl2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra Sh3gl2 O35179 Synj1 Rattus norvegicus Q62910
Pull Down
9238017
Intra Sh3gl2 O35179 Synj1 Rattus norvegicus Q62910
Far-WB
9238017
Intra Sh3gl2 O35179 Dnm1 Rattus norvegicus P21575
Anti Bait CoIP
17437541
Intra Sh3gl2 O35179 Dnm1 Rattus norvegicus P21575
Pull Down
16221862
Intra Sh3gl2 O35179 Dnm1 Rattus norvegicus P21575
Far-WB
9238017
Intra Sh3gl2 O35179 Dnm1 Rattus norvegicus P21575
Pull Down
9238017
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12837 SH3GL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sh3gl2 NCBI NCBI:6456
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